Extract of Schisandra chinensis fruit protects against metabolic dysfunction in high‐fat diet induced obese mice via FXR activation

2020 ◽  
Vol 34 (11) ◽  
pp. 3063-3077
Author(s):  
Ming Gu ◽  
Haiyan Song ◽  
Yiping Li ◽  
Yuwei Jiang ◽  
Yali Zhang ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Schisandra Chinensis ◽  
Metabolic Dysfunction ◽  
Obese Mice ◽  
High Fat

scholarly journals Dietary Momordica Cochinchinensis aril ameliorates metabolic dysfunction, nonalcoholic fatty liver, and gut microbiota in diet-induced obese mice

2020 ◽  
Author(s):  
Yu-Chun Lin ◽  
Hsiu-Chen Huang ◽  
Yu-Heng Lai ◽  
Jui-Chieh Chen ◽  
Hsiao-Hsuan Tien ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Metabolic Dysfunction ◽  
Obese Mice ◽  
High Fat ◽  
Nonalcoholic Fatty Liver ◽  
Momordica Cochinchinensis

Abstract Background Obesity and its associated conditions, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), are a particular worldwide health problem at present. Momordica cochinchinensis fruit is consumed widely in Southeast Asia. However, whether it has functional effects on fat-induced metabolic dysfunction and gut microbiota remains unclear. This study was conducted to determine how Momordica cochinchinensis aril (MCA) affects obesity, nonalcoholic fatty liver, insulin resistance and gut microbiota in diet-induced obese mice.Methods Wild type male mice at age of 5 weeks received four different kinds of diets: a normal diet, high-fat diet (HFD), or HFD supplemented with 1% or 3% (wt:wt) lyophilized MCA for 10 weeks. Body weight, adipose tissue and liver weight, serum biochemical parameters, glucose tolerance and liver lipids were measured. Gut microbial composition was analyzed.Results MCA protected the mice against high-fat diet (HFD)-induced body weight gain, hyperlipidemia and hyperglycemia, compared with mice that were not treated. MCA inhibited the expansion of adipose tissue and adipocyte hypertrophy. In addition, the insulin sensitivity-associated index that evaluates insulin function was also significantly restored. MCA also regulated the secretion of adipokines in HFD-induced obese mice. Moreover, hepatic fat accumulation and liver inflammation were reduced, which suggested that fatty liver was prevented by MCA. Furthermore, MCA supplementation suppressed hepatic lipid accumulation by activation of AMPK and PPAR-alpha signaling pathway in the human fatty liver HuS-E/2 cell model. Supplementation with MCA resulted in microbiota populations changed significantly.Conclusion Our data indicate that dietary MCA is involved in the prevention of HFD-induced adiposity, insulin resistance and nonalcoholic fatty liver disease and altered the microbial contents of the gut and modulated microbial dysbiosis in the host.

scholarly journals MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice

Biomaterials ◽  
2021 ◽  
Vol 278 ◽  
pp. 121183
Author(s):  
Mingming Song ◽  
Shiyao Zhang ◽  
Zixuan Tao ◽  
Jianning Li ◽  
Yujie Shi ◽  
...  
Keyword(s):  
Small Intestine ◽  
High Fat Diet ◽  
Metabolic Dysfunction ◽  
Obese Mice ◽  
High Fat

Topical Application of Capsaicin Reduces Visceral Adipose Fat by Affecting Adipokine Levels in High-Fat Diet-Induced Obese Mice

Obesity ◽  
2012 ◽  
Author(s):  
Gong-Rak Lee ◽  
Mi Kyung Shin ◽  
Dong-Joon Yoon ◽  
Ah-Ram Kim ◽  
Rina Yu ◽  
...  
Keyword(s):  
Topical Application ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Visceral Adipose

Proteomic analysis of the anti-obesity effect of Taeumjowui-Tang in high fat diet-induced obese mice

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
E Changkyun Park ◽  
SY Lee ◽  
SH Yun ◽  
WY Kim ◽  
Y Yi ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat

Inhibition of Adipose Tissue Angiogenesis Prevents Rebound Weight Regain after Calorie Restriction Independent of Hypothalamic Melanocortin System in Obese Mice Fed a High-Fat Diet

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 287-LB
Author(s):  
HYE-JIN LEE ◽  
MUN-GYU SONG ◽  
NA-HEE HA ◽  
BO-YEONG JIN ◽  
SANG-HYUN CHOI ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Calorie Restriction ◽  
High Fat Diet ◽  
Weight Regain ◽  
Obese Mice ◽  
High Fat ◽  
Melanocortin System

Lipolytic Effect of Sparassis crispa Extracts in Differentiated 3T3-L1 Cells and High Fat Diet-induced Obese Mice

2012 ◽  
Vol 41 (12) ◽  
pp. 1708-1715 ◽  
Author(s):  
Mi-Ae Lee ◽  
Jin-Kyung Park ◽  
Mi-Hyang Um ◽  
Jung-Woo Jeon ◽  
Jung-Min Lee ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Lipolytic Effect ◽  
Sparassis Crispa
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