Efficacy of natural, peroxide‐free tooth‐bleaching agents: A systematic review, meta‐analysis, and technological prospecting

2019 ◽  
Vol 34 (5) ◽  
pp. 1060-1070 ◽  
Author(s):  
Juliana Silva Ribeiro ◽  
Wellington Luiz Oliveira da Rosa ◽  
Adriana Fernandes Silva ◽  
Evandro Piva ◽  
Rafael Guerra Lund
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Tooth Bleaching ◽  
Tooth Bleaching Agents

scholarly journals Can tooth bleaching agents cause genotoxicity in the oral epithelium? A systematic review with meta-analysis

2022 ◽  
Vol 11 (1) ◽  
pp. e11411124928
Author(s):  
Liciane dos Santos Menezes ◽  
Patrícia Miranda Leite Ribeiro ◽  
Wilton Mitsunari Takeshita
Keyword(s):  
Systematic Review ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Research Question ◽  
Tooth Bleaching ◽  
P Value ◽  
Oral Epithelium ◽  
Level Of Evidence ◽  
Before And After ◽  
Tooth Bleaching Agents

Objective: To assess, with a systematic review (SR) with meta-analysis, the occurrence of genotoxic effects on the oral epithelium after exposure to tooth bleaching agents. Material and methods: This review was performed according to the PRISMA protocols. To identify relevant studies, a systematic search was performed in the following electronic databases: PubMed, Scopus, Embase, LILACS, and Google Scholar. The research question was "Can tooth bleaching agents cause genotoxicity in the oral epithelium?”. The treatment effects were defined as the standardized mean difference (SMD) and 95% confidence intervals (CI) were established. Results: 154 studies were selected and, after screening titles and abstracts, seven full-text manuscripts were assessed for eligibility, of which four studies were included in the meta-analysis. There were no statistically significant differences in the frequency of micronuclei before and after exposure (SMD= -0.14, 95% CI, 0.98 to 0.60, p=0.74), with a Tau2 index = 1.00; Chi2 = 70.20; p-value <0.00001; and I² of 93%, indicating high heterogeneity among the studies. Conclusion: Considering the limitations of the present SR, tooth bleaching agents do not lead to genotoxic damage in the oral epithelium but with a small effect and low level of evidence. In this way, the use of tooth bleaching agents is safe on the oral mucosa but randomized clinical trials that are more standardized in all stages are required to produce more robust evidence.

Effect of Analgesic Drugs on Tooth Sensitivity Induced by In-office Dental Bleaching: A Systematic Review and Meta-analysis

2020 ◽  
Vol 45 (2) ◽  
pp. E66-E76 ◽  
Author(s):  
RTF Costa ◽  
SLD Moraes ◽  
CAA Lemos ◽  
JR SoutoMaior ◽  
BC do E Vasconcelos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Drug Group ◽  
Preemptive Analgesia ◽  
Tooth Bleaching ◽  
Tooth Sensitivity ◽  
Time Points ◽  
Significant Difference ◽  
Anti Inflammatory ◽  
Time Point

SUMMARY Objective: This systematic review evaluates the effect of preemptive analgesia on tooth sensitivity induced by in-office tooth bleaching. Methods: The review was structured based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist. The methods were recorded at PROSPERO (CRD42018095440). Randomized clinical trials, studies published in English, and studies in which the efficacy of preemptive analgesia with analgesic and anti-inflammatory medications prior to in-office tooth bleaching was compared with that of placebo were included. PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library were used for searching. The electronic search provided 373 articles, and seven of them were selected based on the inclusion criteria. Results: Immediately after time point, a significant reduction of dental sensitivity was observed in the drug group compared to the control group (p=0.02; mean difference [MD]: −0.90; confidence interval [CI]: −1.63 to −0.16), while there was no significant difference at up to one-hour (p=0.22; MD: −0.42; CI: −1.09 to −0.25), at 1-24–hour (p=0.88; MD: −0.05; CI: −0.61 to 0.72), or 24-48–hour (p=0.69; MD: 0.05; CI: −0.21 to 0.32) time points. The incidence of sensitivity during the procedure was not statistically different between the groups (p=0.64; MD: 0.91; CI: 0.92 to 1.15). The nonsteroidal anti-inflammatory drug group showed a statistically significant reduction (p=0.04; MD: −0.69; CI: −1.36 to −0.03) in tooth sensitivity compared with the other groups. Conclusions: This systematic review and meta-analysis demonstrated that the medications analyzed did not interfere with the incidence of sensitivity symptoms. Regarding the intensity, no difference was observed between the drug and placebo groups at the up to one-hour, 1-24–hour, or 24-48–hour time points, and there was a statistically significant difference at the zero-hour time point in favor of the drug group. However, based on the variables that influenced this result, it should be considered with prudence because a small difference was observed.

scholarly journals Influence of tooth bleaching on dental enamel microhardness: a systematic review and meta-analysis

2017 ◽  
Vol 62 (3) ◽  
pp. 276-282 ◽  
Author(s):  
J Zanolla ◽  
ABC Marques ◽  
DC da Costa ◽  
AS de Souza ◽  
M Coutinho
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Dental Enamel ◽  
Tooth Bleaching

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

The association between dietary inflammatory index and risk of central obesity in adults: An updated systematic review and meta-analysis

2020 ◽  
Vol 90 (5-6) ◽  
pp. 535-552 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Mahdi Vajdi
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Central Obesity ◽  
Assessment Tool ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Dietary Factors ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Obesity Indices

Abstract. Backgrounds: Central obesity, as a pivotal component of metabolic syndrome is associated with numerous co-morbidities. Dietary factors influence central obesity by increased inflammatory status. However, recent studies didn’t evaluate the association between central obesity and dietary inflammation index (DII®) that give score to dietary factors according to their inflammatory potential. In the current systematic review and meta-analysis, we summarized the studies that investigated the association between DII® with central obesity indices in the general populations. Methods: In a systematic search from PubMed, SCOPUS, Web of Sciences and Cochrane electronic databases, we collected relevant studies written in English and published until 30 October 2019. The population of included studies were apparently healthy subjects or individuals with obesity or obesity-related diseases. Observational studies that evaluated the association between DII® and indices of central obesity including WC or WHR were included. Results: Totally thirty-two studies were included; thirty studies were cross-sectional and two were cohort studies with 103071 participants. Meta-analysis of observational studies showed that higher DII® scores were associated with 1.81 cm increase in WC (Pooled weighted mean difference (WMD) = 1.813; CI: 0.785–2.841; p = 0.001). Also, a non-significant increase in the odds of having higher WC (OR = 1.162; CI: 0.95–1.43; p = 0.154) in the highest DII category was also observed. In subgroup analysis, the continent, dietary assessment tool and gender were the heterogeneity sources. Conclusion: The findings proposed that adherence to diets with high DII® scores was associated with increased WC. Further studies with interventional designs are necessary to elucidate the causality inference between DII® and central obesity indices.

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