Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients

2019 ◽  
Vol 33 (4) ◽  
pp. 1173-1181 ◽  
Author(s):  
Zohreh Adab ◽  
Shahryar Eghtesadi ◽  
Mohammad‐Reza Vafa ◽  
Iraj Heydari ◽  
Asieh Shojaii ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidant Capacity ◽  
Lipid Profile ◽  
Total Antioxidant Capacity ◽  
Glycemic Status ◽  
Total Antioxidant ◽  
Hs Crp

Interaction between Apo A-II -265T>C Polymorphism and Dietary Total Antioxidant Capacity on Some Oxidative Stress and Inflammatory Markers in Patients with Type 2 Diabetes Mellitus

2021 ◽  
pp. 1-41
Author(s):  
Banafsheh Jafari Azad ◽  
Mehdi Yaseri ◽  
Elnaz Daneshzad ◽  
Fariba Koohdani
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Total Antioxidant ◽  
Hs Crp ◽  
Dietary Total Antioxidant Capacity

Abstract This work aims to examine the interaction between Apolipoprotein A2 (Apo A-II) −265T>C single nucleotide polymorphism (SNP) and dietary total antioxidant capacity (DTAC) on inflammation and oxidative stress in patients with type 2 diabetes mellitus. The present cross-sectional study included 180 patients (35-65 years) with identified Apo A-II genotype. Dietary intakes were assessed by a food frequency questionnaire. DTAC was computed using the international databases. Interleukin-18(IL18), high-sensitivity C-reactive protein (hs-CRP), and pentraxin (PTX3), serum total antioxidant capacity (TAC), superoxide dismutase activity (SOD), and 8-isoprostaneF2α (PGF2α) markers were obtained according to standard protocols. General linear model was used to evaluate the interaction. The interaction of gene and DTAC (PFRAP=0.039 and PORAC=0.042) on PGF2α level was significant after adjusting for confounders. A significant interaction was observed on IL18 level (PORAC=0.018 and PFRAP=0.048) and SOD (PTEAC=0.037) in obese patients. Among patients whose DTAC was higher than the median intake, the levels of hs-CRP and PGF2α were significantly higher only in individuals with CC genotype. Serum TAC (PFRAP=0.030, PORAC=0.049) and SOD were significantly lower in the CC genotype. There was a favorable relationship between the high-DTAC and SOD (Obese: PTEAC=0.034, Non-obese: PFRAP=0.001, PTRAP<0.0001, PTEAC=0.003 and PORAC=0.001) and PGF2α (Non-obese: PORAC=0.024) in T-allele carriers. The rs5082 SNP interacts with DTAC to influence several cardio-metabolic risk factors. Also, we found dietary recommendations for antioxidant-rich foods intake might be useful in the prevention of diabetes complications in the T carrier more effectively than the CC genotype. Future large studies are required to confirm these results.

scholarly journals Serum Lipoprotein (a) Levels in Black South African Type 2 Diabetes Mellitus Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Jim Joseph ◽  
Farzana Ganjifrockwala ◽  
Grace George
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidant Capacity ◽  
South African ◽  
Total Antioxidant Capacity ◽  
Lipoprotein A ◽  
Black South African ◽  
Total Antioxidant

Lipoprotein (a) (Lp(a)) which is a low-density lipoprotein-like particle containing apo(a) is considered as an emergent cardiovascular risk factor. Type 2 diabetes mellitus (T2DM) is associated with a two- to threefold increase in the risk of cardiovascular disease (CVD). The aim of this study was to investigate the levels of Lp(a) in Black South African T2DM patients and its association with other metabolic factors. 67 T2DM patients and 48 healthy control participants were recruited for the cross-sectional study. The Lp(a) level was determined by ELISA and the result was analyzed using SPSS. The Lp(a) level in diabetics was found to be significantly increased (P=0.001) when compared to the normal healthy group. In the diabetic group, the Lp(a) levels correlated significantly with the duration of diabetes (P=0.008) and oxidized LDL (ox-LDL) levels (P=0.03) and decreased total antioxidant capacity (P=0.001). The third tertile of Lp(a) was significantly correlated with increased ox-LDL, C-reactive protein, and triglycerides and decreased total antioxidant capacity.

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