Vitis vinifera(grape) seed extract and resveratrol alleviate bisphenol-A-induced metabolic syndrome: Biochemical and molecular evidences

2019 ◽  
Vol 33 (3) ◽  
pp. 832-844 ◽  
Author(s):  
Maryam Rameshrad ◽  
Bibi Marjan Razavi ◽  
Mohsen Imenshahidi ◽  
Hossein Hosseinzadeh
Keyword(s):  
Metabolic Syndrome ◽  
Bisphenol A ◽  
Vitis Vinifera ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract

Bisphenol A vascular toxicity: Protective effect of Vitis vinifera (grape) seed extract and resveratrol

2018 ◽  
Vol 32 (12) ◽  
pp. 2396-2407 ◽  
Author(s):  
Maryam Rameshrad ◽  
Mohsen Imenshahidi ◽  
Bibi Marjan Razavi ◽  
Mehrdad Iranshahi ◽  
Hossein Hosseinzadeh
Keyword(s):  
Bisphenol A ◽  
Protective Effect ◽  
Vitis Vinifera ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Vascular Toxicity

scholarly journals Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations—A Systematic Review of the Literature

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1692
Author(s):  
Teresa Grohmann ◽  
Caroline Litts ◽  
Graham Horgan ◽  
Xuguang Zhang ◽  
Nigel Hoggard ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Ldl Cholesterol ◽  
Cholesterol Metabolism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Good Evidence ◽  
Seed Extract

Intervention with fruit extracts may lower glucose and lipid levels, as well as blood pressure. We reviewed the efficacy of bilberry and grape seed extracts to affect these outcomes across populations with varying health status, age and ethnicity, across intervention doses and durations, in 24 intervention studies with bilberry and blackcurrant (n = 4) and grape seed extract (n = 20). Bilberry and blackcurrant extract lowered average levels of glycated hemoglobin (HbA1c), at least in Chinese subjects, especially in those who were older, who were diagnosed with Type 2 Diabetes Mellitus (T2DM) and who were participating in longer-term studies. We also found good evidence that across studies and in subjects with hypercholesterolemia, T2DM or metabolic syndrome, intervention with bilberry and blackcurrant extract, and to some extent grape seed extract, significantly lowered total and low density lipoprotein (LDL) cholesterol levels after four weeks. Intervention with grape seed extract may reduce systolic and diastolic blood pressure in subjects with hypertension or metabolic syndrome. Differential responsiveness in cholesterol and blood pressure outcomes between stratified populations could not be explained by age, dose or study duration. In conclusion, bilberry and blackcurrant extract appears effective in lowering HbA1c and total and LDL cholesterol, whereas grape seed extract may lower total and LDL cholesterol, and blood pressure, in specific population groups.

Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome

Metabolism ◽  
2009 ◽  
Vol 58 (12) ◽  
pp. 1743-1746 ◽  
Author(s):  
Brahmesh Sivaprakasapillai ◽  
Indika Edirisinghe ◽  
Jody Randolph ◽  
Francene Steinberg ◽  
Tissa Kappagoda
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
The Metabolic Syndrome

scholarly journals Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome - randomized, cross-over, placebo-controlled study

2013 ◽  
Vol 2 (12) ◽  
pp. 508 ◽  
Author(s):  
Indika Edirisinghe ◽  
Jody Randolph ◽  
Mandeep Cheema ◽  
Ravi Tadapaneni ◽  
Eunyoung Park ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Inflammatory Markers ◽  
Oxidized Ldl ◽  
Area Under The Curve ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Controlled Study ◽  
The Metabolic Syndrome

Objective: This investigation was undertaken to determine whether a grape seed extract (GSE) that is rich in mono-, oligo- and poly- meric polyphenols would modify postprandial oxidative stress and inflammation in individuals with the metabolic syndrome (MetS).Background: MetS is known to be associated with impaired glucose tolerance and poor glycemic control. Consumption of a meal high in readily available carbohydrates and fat causes postprandial increases in glycemia and lipidemia and markers of oxidative stress, inflammation and insulin resistance.Materials/methods: After an overnight fast, twelve subjects with MetS (5 men and 7 women) consumed a breakfast meal high in fat and carbohydrate in a cross-over design. A GSE (300 mg) or placebo capsule was administrated 1 hr before the meal (-1 hr). Changes in plasma insulin, glucose, oxidative stress and inflammatory markers were measured hourly for 6 hr. Results: Plasma hydrophilic oxygen radical absorbance capacity (ORAC) measured as the positive incremental area under the curve (-1 to 5 hr) was significantly increased when the meal was preceded by GSE compared with placebo (P<0.05). Meal-induced increases in oxidized LDL were attenuated with GSE (P<0.05). Plasma glucose concentrations (area under the curve from -1 to 5 hr) were also significantly lower when the meal was preceded by GSE (P<0.05) while the insulin concentrations remained unchanged (P>0.05). No changes in inflammatory markers were evident. Conclusion: These data suggest that GSE enhances postprandial plasma antioxidant status and reduces the glycemic response to a meal, high in fat and carbohydrate in subjects with the MetS. Key words: Polyphenols, Oxidative stress, Inflammation, ORAC, Oxidized LDL

scholarly journals Induction of apoptosis by grape seed extract (Vitis vinifera) in oral squamous cell carcinoma

2013 ◽  
Vol 13 (3) ◽  
pp. 186 ◽  
Author(s):  
Amirala Aghbali ◽  
Sepideh Vosough Hosseini ◽  
Abbas r Delaza ◽  
Nader Kalbasi Gharavi ◽  
Fatemeh Zare Shahneh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Vitis Vinifera ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Induction Of Apoptosis

scholarly journals Proanthocyanidin-Rich Grape Seed Extract Reduces Inflammation and Oxidative Stress and Restores Tight Junction Barrier Function in Caco-2 Colon Cells

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1623 ◽  
Author(s):  
Rameshprabu Nallathambi ◽  
Alexander Poulev ◽  
Joshua B. Zuk ◽  
Ilya Raskin
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Tight Junction ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Cytokine Gene Expression ◽  
Colon Cells ◽  
Barrier Integrity ◽  
Beneficial Effects

Grape polyphenols have previously been shown to improve gut health and attenuate the symptoms of metabolic syndrome; however, the mechanism of these beneficial effects is still debated. In this study, we investigated the protective effect of proanthocyanidin-rich grape seed extract (GSE) on bacterial lipopolysaccharide (LPS)-induced oxidative stress, inflammation, and barrier integrity of human Caco-2 colon cells. GSE significantly reduced the LPS-induced intracellular reactive oxygen species (ROS) production and mitochondrial superoxide production, and upregulated the expression of antioxidant enzyme genes. GSE also restored the LPS-damaged mitochondrial function by increasing mitochondrial membrane potential. In addition, GSE increased the expression of tight junction proteins in the LPS-treated Caco-2 cells, increased the expression of anti-inflammatory cytokines, and decreased pro-inflammatory cytokine gene expression. Our findings suggest that GSE exerts its beneficial effects on metabolic syndrome by scavenging intestinal ROS, thus reducing oxidative stress, increasing epithelial barrier integrity, and decreasing intestinal inflammation.

scholarly journals Grape seed extract attenuates oxidative stress induced by high fat/carbohydrate meal in metabolic syndrome patients

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Ravi Kiran Tadapaneni ◽  
Sandhya Krishnankutty ◽  
Lourdes Alandete ◽  
Jody M. Randolph ◽  
Mandeep Cheema ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
High Fat ◽  
Carbohydrate Meal
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