The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta-analysis of animal studies

2018 ◽  
Vol 33 (1) ◽  
pp. 55-71 ◽  
Author(s):  
Shabnam Salekzamani ◽  
Mehrangiz Ebrahimi-Mameghani ◽  
Khatereh Rezazadeh
Keyword(s):  
Systematic Review ◽  
Antioxidant Activity ◽  
Animal Studies ◽  
Meta Analysis ◽  
Cynara Scolymus

scholarly journals Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Kei Hayashida ◽  
Ryosuke Takegawa ◽  
Muhammad Shoaib ◽  
Tomoaki Aoki ◽  
Rishabh C. Choudhary ◽  
...  
Keyword(s):  
Systematic Review ◽  
Reperfusion Injury ◽  
Animal Studies ◽  
Ischemia Reperfusion Injury ◽  
Myocardial Dysfunction ◽  
Ischemia Reperfusion ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Human Studies ◽  
Cochrane Library

Abstract Background Mitochondria are essential organelles that provide energy for cellular functions, participate in cellular signaling and growth, and facilitate cell death. Based on their multifactorial roles, mitochondria are also critical in the progression of critical illnesses. Transplantation of mitochondria has been reported as a potential promising approach to treat critical illnesses, particularly ischemia reperfusion injury (IRI). However, a systematic review of the relevant literature has not been conducted to date. Here, we systematically reviewed the animal and human studies relevant to IRI to summarize the evidence for mitochondrial transplantation. Methods We searched MEDLINE, the Cochrane library, and Embase and performed a systematic review of mitochondrial transplantation for IRI in both preclinical and clinical studies. We developed a search strategy using a combination of keywords and Medical Subject Heading/Emtree terms. Studies including cell-mediated transfer of mitochondria as a transfer method were excluded. Data were extracted to a tailored template, and data synthesis was descriptive because the data were not suitable for meta-analysis. Results Overall, we identified 20 animal studies and two human studies. Among animal studies, 14 (70%) studies focused on either brain or heart IRI. Both autograft and allograft mitochondrial transplantation were used in 17 (85%) animal studies. The designs of the animal studies were heterogeneous in terms of the route of administration, timing of transplantation, and dosage used. Twelve (60%) studies were performed in a blinded manner. All animal studies reported that mitochondrial transplantation markedly mitigated IRI in the target tissues, but there was variation in biological biomarkers and pathological changes. The human studies were conducted with a single-arm, unblinded design, in which autologous mitochondrial transplantation was applied to pediatric patients who required extracorporeal membrane oxygenation (ECMO) for IRI–associated myocardial dysfunction after cardiac surgery. Conclusion The evidence gathered from our systematic review supports the potential beneficial effects of mitochondrial transplantation after IRI, but its clinical translation remains limited. Further investigations are thus required to explore the mechanisms of action and patient outcomes in critical settings after mitochondrial transplantation. Systematic review registration The study was registered at UMIN under the registration number UMIN000043347.

scholarly journals Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142021 ◽  
Author(s):  
Kimberley E. Wever ◽  
Carlijn R. Hooijmans ◽  
Niels P. Riksen ◽  
Thomas B. Sterenborg ◽  
Emily S. Sena ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Preconditioning ◽  
Animal Studies ◽  
Meta Analysis

scholarly journals Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

2018 ◽  
Vol 212 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Akihiro Takamiya ◽  
Jun Ku Chung ◽  
Kuo-ching Liang ◽  
Ariel Graff-Guerrero ◽  
Masaru Mimura ◽  
...  
Keyword(s):  
Systematic Review ◽  
Electroconvulsive Therapy ◽  
Animal Studies ◽  
Brain Volume ◽  
Meta Analysis ◽  
Brain Structures ◽  
Volume Increase ◽  
Left Hippocampus ◽  
Before And After ◽  
Underlying Mechanisms

BackgroundElectroconvulsive therapy (ECT) is one of the most effective treatments for depression, although the underlying mechanisms remain unclear. Animal studies have shown that electroconvulsive shock induced neuroplastic changes in the hippocampus.AimsTo summarise volumetric magnetic resonance imaging studies investigating the effects of ECT on limbic brain structures.MethodA systematic review and meta-analysis was conducted to assess volumetric changes of each side of the hippocampus and amygdala before and after ECT. Standardised mean difference (SMD) was calculated.ResultsA total of 8 studies (n = 193) were selected for our analyses. Both right and left hippocampal and amygdala volumes increased after ECT. Meta-regression analyses revealed that age, percentage of those responding and percentage of those in remission were negatively associated with volume increases in the left hippocampus.ConclusionsECT increased brain volume in the limbic structures. The clinical relevance of volume increase needs further investigation.Declaration of interestNone.

scholarly journals Moxibustion for cognitive impairment: a systematic review and meta-analysis of animal studies

2020 ◽  
pp. 100680
Author(s):  
Sungmin Aum ◽  
Seon Choe ◽  
Mudan Cai ◽  
Ui Min Jerng ◽  
Jun-Hwan Lee
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Animal Studies ◽  
Meta Analysis

scholarly journals Effectiveness of Salvia Officinalis on Mediation of Serum Lipid in Clinical Trials: Systematic Review and Meta-analysis (P12-004-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sepideh Alasvand ◽  
WIlliam Bridges ◽  
Vivian Haley-Zitlin
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Chronic Disease ◽  
Serum Lipid ◽  
Animal Studies ◽  
Serum Lipids ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Salvia Officinalis ◽  
Lipoprotein Cholesterol

Abstract Objectives The present systematic review and meta-analysis investigates the effectiveness of S. officinalis leaves in management of dyslipidemia of chronic disease. Dyslipidemia is one of the main indicators of cardiovascular disease (CVD). It is typically characterized by elevated levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglyceride (TG) along with reduction of high-density lipoprotein cholesterol (HDL) in blood. The handling of dyslipidemia is a crucial factor in the general control of the cardiovascular risk in individuals suffering from diseases such as diabetes, CVD or hypertension. Plant foods have played an important role in chronic disease management. S. officinalis leaves (sage) have been identified as improving glucose homeostasis and serum lipids in animal and human models. Methods PubMed, FSTA, Web of Science, CINAHEL and MEDLINE databases were searched using keywords (“Serum lipids” OR triglyceride* OR cholesterol* OR “LDL” OR “HDL” OR dyslipidemia) AND (sage or "Salvia officinalis") up to January 2019. Review articles, animal studies, non-trial, non-specific related plants, and articles which did not examine lipid profiles were included in the exclusion criteria. Articles that met the inclusion criteria included effects of administration of Salvia officinalis on serum lipid in clinical trials. All statistical calculations were performed using SAS software version 9.2 (SAS, Cary NC, USA). Results From 243 studies, four of the trials met the selection criteria of the meta-analysis. Salvia officinalis significantly improved serum lipids. The estimated value for TC was −52.64 mg/dl, 95% CI: −71.0505 to −34.23, P = 0.0001 and LDL −23.28 mg/dl, 95% CI: −40.07 to −6.48, P = 0.006. Moreover, TG was −74.98 mg/dl, 95% CI: −129.16 to −20.8190, P = 0.006 and HDL-C at 6.3424 mg/dl, 95% CI: 1.58 to 11.1033, P = 0.009) was significantly improved after Salvia officinalis administration Conclusions Although the systematic review and meta-analysis investigation involved few studies it revealed promising efficiency of Salvia officinalis on improving the serum lipids in clinical trials and suggested that Salvia officinalis can be an appropriate plant food to manage dyslipidemia of chronic diseases. Funding Sources N/A.

scholarly journals Use of Qishen granule for the treatment of heart failure: A systematic review and meta-analysis of animal studies

2020 ◽  
Vol 7 (2) ◽  
pp. 121-132
Author(s):  
Junjie Liu ◽  
Shuangjie Yang ◽  
Wei Wang ◽  
Yili Zhang ◽  
Qiyan Wang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Animal Studies ◽  
Meta Analysis

scholarly journals A Systematic Review Protocol of The Antiviral Activity of Chloroquine and Hydroxychloroquine Against COVID-19.

2020 ◽  
Author(s):  
Kofi Boamah Mensah ◽  
Adwoa Bemah Boamah Mensah ◽  
Varsha Bangalee ◽  
Frasia Oosthuizen
Keyword(s):  
Systematic Review ◽  
Antiviral Activity ◽  
Animal Studies ◽  
Data Extraction ◽  
Meta Analysis ◽  
Drug Action ◽  
Bibliographic Databases ◽  
Publication Date ◽  
Reference Manager

Abstract Background: The recent outbreak of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), or COVID-19 with no approved medicines has led to global health threat. Currently, repositioning of old medicines seems the most responsible strategy for potential cure and prevention COVID-19. Hydroxychloroquine and chloroquine have shown promising efficacy against COVID-19 related pneumonia in clinical studies. However, the mode of drug action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection is not clear. This review aims to gather evidence on antiviral activity and possible mechanism of drug action of chloroquine and hydroxychloroquine on SARS-CoV-2, including in-vitro, animal studies, and studies in humans.Method: A structured search of five bibliographic databases namely; Medline, Web of Science, PubMed, Cochrane CENTRAL, and Google Scholar will be undertaken to retrieve studies that describe the antiviral activity and possible mechanism of drug action of chloroquine and hydroxychloroquine on SARS-CoV-2. No restrictions will be placed on publication date, but studies will be limited to only publications in English. Duplication of studies will be removed using EndNote reference manager. Three authors will screen the citations independently based on inclusion criteria. Data extraction and assessment of risk of bias will be done independently. Meta-analysis of selected studies will be done wherever suitable.Discussion: We expect that data that will be synthesis will provide enough information to inform COVID-19 care pathways and help clinicians caring for COVID-19 patients. Furthermore, this systematic review will expand our knowledge on the benefits and risks of chloroquine and hydroxychloroquine in management of COVID-19 patients and identify areas of controversies, and quality assessment. This review will provide vital information needed in the development of contextualized guidelines for the management of COVID-19 patients.Systematic review registration: https://doi.org/10.17605/OSF.IO/7DJMU

scholarly journals Immunogenicity and safety of adenovirus-based vector vaccines for COVID-19: a systematic review and meta-analysis

2021 ◽  
Vol 30 (4) ◽  
pp. 264-78
Author(s):  
Ayers Gilberth Ivano Kalaij ◽  
Valerie Josephine Dirjayanto ◽  
Syarif Maulana Yusuf ◽  
Erni Juwita Nelwan
Keyword(s):  
Systematic Review ◽  
Animal Studies ◽  
Vaccine Development ◽  
Meta Analysis ◽  
Fixed Effect Model ◽  
Effective Vaccine ◽  
Forest Plot ◽  
Vector Vaccine ◽  
Effect Model ◽  
Meta Analyses

BACKGROUND Despite various research on vaccine development, severe acute respiratory syndrome coronavirus 2 infection continues to spread. Thus, developing a more effective vaccine for production and clinical efficacy is still in high demand. This review aimed to assess the immunogenicity and safety of adenovirus-based vector vaccine (Ad-vaccines) including Ad5-vectored, ChAdOx1 nCoV-19, rAd26-S or rAd5-S, and Ad26.COV2.S as the promising solutions for COVID-19. METHODS We conducted a systematic review and meta analysis of clinical trials based on the preferred reporting items for systematic reviews and meta-analyses guidelines through PubMed, Scopus, Cochrane, and EBSCOhost until August 17, 2021. We implemented inclusion and exclusion criteria and assessed the studies using OHAT risk of bias rating tool for human and animal studies. Pooled estimates of odds ratio (OR) were analyzed using fixed-effect model. RESULTS This systematic review yielded 12 clinical studies with a total of 75,105 subjects. Although the studies were heterogeneous, this meta-analysis showed that Ad-vaccine significantly increased protection and immune response against COVID-19 with a pooled efficacy of 84.68% compared to placebo (p<0.00001). Forest plot also indicated that Ad-vaccine conferred protection against moderate to severe COVID-19 with a pooled OR of 0.26 (p<0.00001). Ad-vaccine had also shown a good safety profile with local site pain and fever as the most common side effects. CONCLUSIONS Ad-vaccine had shown a good immunogenicity for COVID-19 with a good pooled efficacy and was proven safe for COVID-19 patients.

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