Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

2015 ◽  
Vol 30 (1) ◽  
pp. 152-159 ◽  
Author(s):  
Marco A. Botelho ◽  
Gisele Barros ◽  
Dinalva B. Queiroz ◽  
Celso Felício Carvalho ◽  
Julia Gouvea ◽  
...  
Keyword(s):  
Antiinflammatory Effect ◽  
Lippia Sidoides ◽  
Acute Periodontitis

Quantitative relations between structure and antiinflammatory activity of aryloxoalkanoic acids

1988 ◽  
Vol 53 (8) ◽  
pp. 1862-1872 ◽  
Author(s):  
Miroslav Kuchař ◽  
Eva Maturová ◽  
Bohumila Brunová ◽  
Jaroslava Grimová ◽  
Hana Tomková ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Structural Changes ◽  
Antiinflammatory Activity ◽  
Structural Parameters ◽  
Considerable Effect ◽  
Antiinflammatory Effect ◽  
Prolonged Action ◽  
Preclinical Development ◽  
Indicator Variables ◽  
Inhibitory Activities

The antiinflammatory effect of a series of aryloxoalkanoic acids II and of their biphenyl derivatives III was examined by measuring the inhibition of the development of carageenan- and adjuvant-induced edemas. The quantitative relations between the antiinflammatory effect and physicochemical and structural parameters of the compounds tested were evaluated. The equations obtained by the method of regression analysis showed a significant linear dependence of both inhibitory activities on the lipophilicity of the compounds and a considerable effect of some structural changes as expressed by indicator variables. The antiinflammatory effect is especially enhanced in both tests by the presence of a cyclic substituent at the aromatic ring. The high antiinflammatory effect of biphenylyl derivatives III is paralleled by their prolonged action. The prolongation of the effect is most likely a result of a suitable biotransformation of acid III to an efficient metabolite. The structural requirements which resulted from both the regression analysis and from the hypothesis of biotransformation of acids III were utilized in the synthesis of suitably substituted biphenylyloxoalkanoic acids. By this approach derivatives IIIe-i were obtained some of which showed a high antiinflammatory and also protracted effect. 4-(2',4'-Difluorbiphenylyl)-4-oxo-2-methylbutanoic acid (VÚFB-16 066, Flobufen) was chosen for further preclinical development.

2,4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism

1998 ◽  
Vol 63 (1) ◽  
pp. 103-114 ◽  
Author(s):  
Miroslav Kuchař ◽  
Kateřina Čulíková ◽  
Vladimíra Panajotovová ◽  
Bohumila Brunová ◽  
Antonín Jandera ◽  
...  
Keyword(s):  
Significant Inhibition ◽  
Antiinflammatory Effect ◽  
Acid Moiety ◽  
Activity Mechanism

A series of 2,4-dihydroxy-3-propylacetophenone derivatives containing alkylthiobenzoic or arylacetic acid moiety was prepared. The antileukotrienic activity of the substances was assessed in terms of inhibition of the biosynthesis of LTB4 and bonding to LTB4 and LTD4 receptors. Some of the substances were found to exert a complex antileukotrienic effect in all of the three tests. The compounds also displayed an antiinflammatory effect, as manifested by a significant inhibition of LTD4-induced bronchospasm.

Anesthetic potential of the essential oils of Aloysia triphylla, Lippia sidoides and Mentha piperita for Colossoma macropomum

Aquaculture ◽  
2021 ◽  
Vol 534 ◽  
pp. 736275
Author(s):  
Franmir Rodrigues Brandão ◽  
Caio Francisco Santana Farias ◽  
Damy Caroline de Melo Souza ◽  
Maria Inês Braga de Oliveira ◽  
Lorena Vieira de Matos ◽  
...  
Keyword(s):  
Essential Oils ◽  
Mentha Piperita ◽  
Colossoma Macropomum ◽  
Lippia Sidoides ◽  
Aloysia Triphylla

scholarly journals Syntheses of two deacetyl-thymosin β4analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw

2001 ◽  
Vol 10 (2) ◽  
pp. 89-92 ◽  
Author(s):  
T. Abiko ◽  
R. Ogawa
Keyword(s):  
Marked Reduction ◽  
Solid Phase ◽  
The Other ◽  
Para Position ◽  
Phase Method ◽  
Antiinflammatory Effect ◽  
Solid Phase Method ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Two {Met(0)6}deacetyl-thymosin β4analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic {Met(0)6}deacetyl-thymosin β4, but the other analog, {Met(0)6, Tyr(Me)12}deacetyl-thymosin β4, showed a marked reduction of the anti-inflammatory effect.

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