Effect of Trimeric Myricetin Rhamnoside (TMR) in Carrageenan-induced Inflammation and Caecal Ligation and Puncture-induced Lung Oxidative Stress in Mice

2015 ◽  
Vol 29 (11) ◽  
pp. 1798-1805 ◽  
Author(s):  
Najeeb Latief ◽  
Shikha Anand ◽  
Madhu Cholenahalli Lingaraju ◽  
Venkanna Balaganur ◽  
Nitya Nand Pathak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caecal Ligation And Puncture ◽  
Lung Oxidative Stress ◽  
Caecal Ligation

scholarly journals Hypothermia effects on liver and kidney oxidative stress parameters in an experimental model of sepsis in rats

2020 ◽  
Vol 64 (1) ◽  
pp. 187-195
Author(s):  
Bogdan Sidonia ◽  
Rafa Horatiu ◽  
Luca Vlad ◽  
Dulf Francisc ◽  
Ober Ciprian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Concentration ◽  
Saturated Fatty Acids ◽  
Renal Tissue ◽  
Total Protein Concentration ◽  
Liver And Kidney ◽  
Controlled Hypothermia ◽  
Caecal Ligation And Puncture ◽  
Gpx Activity ◽  
Caecal Ligation

AbstractIntroductionOxidative stress (OS) seems to be an important mediator of cellular injury, from which sepsis can proceed. Studies have demonstrated the protective effect of controlled hypothermia in sepsis. This study aimed to evaluate its effects on OS parameters in rat hepatic and renal tissue septic after caecal ligation and puncture (CLP).Material and MethodsThree groups were appointed (10 rats/group): C (control), SN (sepsis normothermic), and SH (sepsis hypothermic). Ten hours from CLP, the liver and kidneys were harvested and total protein concentration, superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, lipid peroxidation level (malondialdehyde (MDA), carbonylated proteins (2,4-dinitrophenylhydrazine (DNPH), and fatty acid profile were analysed.ResultsSepsis significantly increased SOD and GPx activities in the liver, regardless of the temperature. In renal tissue, GPx activity increased significantly in normothermic conditions and SOD tended to decrease in hypothermic conditions. MDA and DNPH concentrations increase in both tissues after CLP. Hypothermia significantly lowered MDA in the liver but only changed it insignificantly in the kidneys. The DNPH in the liver and kidneys was significantly lower in hypothermic conditions. The unsaturated-to-saturated fatty acids ratio was significantly lower in sepsis, and the fall in temperature raised this ratio.ConclusionExperimentally induced sepsis in rats enhances OS in the liver and kidneys. The effect of hypothermia on OS indices is dependent on the type of tissue.

Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats

2018 ◽  
Vol 235 ◽  
pp. 514-524 ◽  
Author(s):  
Thierry Douki ◽  
Cécile Corbière ◽  
David Preterre ◽  
Perrine J. Martin ◽  
Valérie Lecureur ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Comparative Study ◽  
Lung Oxidative Stress

Glutamine and alanine metabolism in lungs of septic rats

1991 ◽  
Vol 81 (5) ◽  
pp. 603-609 ◽  
Author(s):  
M. Salleh M. Ardawi
Keyword(s):  
Blood Flow ◽  
Blood Glucose Concentration ◽  
Plasma Cholesterol ◽  
Marked Change ◽  
Concentration Difference ◽  
Lung Blood Flow ◽  
Caecal Ligation And Puncture ◽  
Caecal Ligation

1. The metabolism of glutamine and alanine in the lung was studied in rats made septic by a caecal ligation and puncture technique. 2. The blood glucose concentration was not significantly different in septic rats, but blood pyruvate, lactate, glutamine and alanine concentrations were markedly increased as compared with sham-operated rats. Conversely, blood ketone body and plasma cholesterol concentrations were significantly decreased in septic rats. Both plasma insulin and plasma glucagon concentrations were markedly elevated in response to sepsis. Sepsis resulted in a negative nitrogen balance. 3. Sepsis increased the rates of production of glutamine (52.5%, P <0.001), alanine (38.9%, P <0.001) and glutamate (48.6%, P <0.001) by lung slices incubated in vitro. 4. Sepsis increased lung blood flow by 27.6% (P <0.05). Blood flow and arteriovenous concentration difference measurement across the lung of septic rats showed an increase in the net exchange rates of glutamine (142.5%, P <0.001), alanine (129.4%, P <0.001), glutamate (100.9%, P <0.001) and ammonia (138.0%, P <0.001) as compared with sham-operated control rats. 5. Sepsis produced significant decreases in the lung concentrations of glutamine (36.8%), glutamate (20.8%), 2-oxoglutarate (64.8%) and AMP (18.3%). The lung concentrations of alanine (95.9%), ammonia (67.7%) and pyruvate (89.7%) were increased. 6. The maximal activities of glutamine synthetase (20.4%, P <0.05), phosphate-dependent glutaminase (18.9%, P <0.05) and alanine aminotransferase (25.5%, P <0.05) were increased, but there was no marked change in that of glutamate dehydrogenase, in the lungs of septic rats. 7. It is concluded that there are enhanced rates of production of glutamine and alanine from lungs of septic rats (both in vitro and in vivo). This may be due to changes in efflux and/or increased intracellular biosynthesis of both glutamine and alanine; these suggestions are discussed.

scholarly journals Intermittent Hypoxia Increases the Severity of Bleomycin-Induced Lung Injury in Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Thomas Gille ◽  
Morgane Didier ◽  
Cécile Rotenberg ◽  
Eva Delbrel ◽  
Dominique Marchant ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pulmonary Fibrosis ◽  
Pulmonary Edema ◽  
Cell Apoptosis ◽  
Lung Fibrosis ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Obstructive Sleep ◽  
The Impact ◽  
Lung Oxidative Stress

Background. Severe obstructive sleep apnea (OSA) with chronic intermittent hypoxia (IH) is common in idiopathic pulmonary fibrosis (IPF). Here, we evaluated the impact of IH on bleomycin- (BLM-) induced pulmonary fibrosis in mice. Methods. C57BL/6J mice received intratracheal BLM or saline and were exposed to IH (40 cycles/hour; FiO2 nadir: 6%; 8 hours/day) or intermittent air (IA). In the four experimental groups, we evaluated (i) survival; (ii) alveolar inflammation, pulmonary edema, lung oxidative stress, and antioxidant enzymes; (iii) lung cell apoptosis; and (iv) pulmonary fibrosis. Results. Survival at day 21 was lower in the BLM-IH group (p<0.05). Pulmonary fibrosis was more severe at day 21 in BLM-IH mice, as assessed by lung collagen content (p=0.02) and histology. At day 4, BLM-IH mice developed a more severe neutrophilic alveolitis, (p<0.001). Lung oxidative stress was observed, and superoxide dismutase and glutathione peroxidase expression was decreased in BLM-IH mice (p<0.05 versus BLM-IA group). At day 8, pulmonary edema was observed and lung cell apoptosis was increased in the BLM-IH group. Conclusion. These results show that exposure to chronic IH increases mortality, lung inflammation, and lung fibrosis in BLM-treated mice. This study raises the question of the worsening impact of severe OSA in IPF patients.

INTERLEUKIN-1 REGULATES ENDOTHELIN-1mRNA EXPRESSION IN LUNG TISSUE DURING CAECAL LIGATION AND PUNCTURE

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 55
Author(s):  
D. Hadjiminas ◽  
D. Exon ◽  
S. Chadwick ◽  
M. Wilson ◽  
W. Cheadle ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Interleukin 1 ◽  
Caecal Ligation And Puncture ◽  
Caecal Ligation

scholarly journals Concomitant exposure to cigarette smoke and coal dust induces lung oxidative stress and decreases serum MUC5AC levels in male rats

2015 ◽  
Vol 7 (2) ◽  
pp. 57-63
Author(s):  
Nia Kania ◽  
Bambang Setiawan ◽  
Edi Widjajanto ◽  
Nurdiana Nurdiana ◽  
M. Aris Widodo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cigarette Smoke ◽  
Coal Dust ◽  
Male Rats ◽  
Concomitant Exposure ◽  
Lung Oxidative Stress

Acute exposure to diesel-biodiesel particulate matter promotes murine lung oxidative stress by Nrf2/HO-1 and inflammation through the NF-κB/TNF-α pathways

2017 ◽  
Vol 112 ◽  
pp. 201
Author(s):  
Samuel dos Santos Valenca ◽  
Isabella Cattani-Cavalieri ◽  
Giovanna Marcella Cavalcante Carvalho ◽  
Walter Araújo Zin ◽  
Andréa Monte Alto Costa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Acute Exposure ◽  
Murine Lung ◽  
Tnf Α ◽  
Lung Oxidative Stress
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