Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells

2015 ◽  
Vol 29 (11) ◽  
pp. 1744-1752 ◽  
Author(s):  
Weimei Ruan ◽  
Ying Wei ◽  
David G. Popovich
Keyword(s):  
Ganoderma Lucidum ◽  
Carcinoma Cells ◽  
Human Carcinoma ◽  
Ganoderma Lucidum Triterpenoids

Mitogenic response of human carcinoma cells to the liver-derived hormone FGF21

2016 ◽  
Vol 11 (03) ◽  
Author(s):  
L Berti ◽  
B Rädle ◽  
HU Häring ◽  
M Hrab((ebrevis)) de Angelis ◽  
H Staiger
Keyword(s):  
Carcinoma Cells ◽  
Mitogenic Response ◽  
Human Carcinoma

Modeling cell response to low doses of photon irradiation: Part 2—application to radiation-induced chromosomal aberrations in human carcinoma cells

2015 ◽  
Vol 55 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Micaela Cunha ◽  
Etienne Testa ◽  
Olga V. Komova ◽  
Elena A. Nasonova ◽  
Larisa A. Mel’nikova ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Cell Response ◽  
Carcinoma Cells ◽  
Low Doses ◽  
Human Carcinoma ◽  
Photon Irradiation ◽  
Radiation Induced

scholarly journals Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HEp2 cells.

1995 ◽  
Vol 128 (4) ◽  
pp. 549-561 ◽  
Author(s):  
R N Ghosh ◽  
F R Maxfield
Keyword(s):  
Steady State ◽  
Digital Image Analysis ◽  
Carcinoma Cells ◽  
Exit Rate ◽  
Human Carcinoma ◽  
First Order ◽  
First Order Kinetics ◽  
Early Endosomes ◽  
Retrograde Traffic ◽  
Endosomal System

We have previously characterized the trafficking of transferrin (Tf) through HEp2 human carcinoma cells (Ghosh, R. N., D. L. Gelman, and F. R. Maxfield, 1994. J. Cell Sci. 107:2177-2189). Early endosomes in these cells are comprised of both sorting endosomes and recycling compartments, which are distinct separate compartments. Endocytosed Tf initially appears in punctate sorting endosomes that also contain recently endocytosed LDL. After short loading pulses, Tf rapidly sorts from LDL with first-order kinetics (t1/2 approximately 2.5 min), and it enters the recycling compartment before leaving the cell (t1/2 approximately 7 min). Here, we report a second, slower rate for Tf to leave sorting endosomes after HEp2 cells were labeled to steady state with fluorescein Tf instead of the brief pulse used previously. We determined this rate using digital image analysis to measure the Tf content of sorting endosomes that also contained LDL. With an 11-min chase, the Tf in sorting endosomes was 24% of steady-state value. This was in excess of the amount expected (5% of steady state) from the rate of Tf exit after short filling pulses. The excess could not be accounted for by reinternalization of recycled cell surface Tf, implying that either some Tf was retained in sorting endosomes, or that Tf was delivered back to the sorting endosomes from the recycling compartment. The former is unlikely since nearly all sorting endosomes contain detectable Tf after an 11-min chase, even though more than one third of the sorting endosomes were formed during the chase time. Furthermore, while observing living cells by confocal microscopy, we saw vesicle movements that appeared to be fluorescent Tf returning from recycling compartments to sorting endosomes. The slow rate of exit after steady-state labeling was similar to the Tf exit rate from the cell, suggesting an equilibration of Tf throughout the early endosomal system by this retrograde pathway. This retrograde traffic may be important for delivering molecules from the recycling compartment, which is a long-lived organelle, to sorting endosomes, which are transient.

Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells

Biochemistry ◽  
1985 ◽  
Vol 24 (20) ◽  
pp. 5480-5486 ◽  
Author(s):  
James W. Fett ◽  
Daniel J. Strydom ◽  
Roy R. Lobb ◽  
Edward M. Alderman ◽  
J. Lemuel Bethune ◽  
...  
Keyword(s):  
Carcinoma Cells ◽  
Human Carcinoma ◽  
Isolation And Characterization

134 Molecular mechanisms of radiation-induced cell proliferation in human carcinoma cells

1996 ◽  
Vol 36 (1) ◽  
pp. 225
Author(s):  
R.K. Schmidt-Ullrich ◽  
R. Mikkelsen ◽  
K. Valerie ◽  
D. Todd ◽  
B. Kavanagh ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Molecular Mechanisms ◽  
Carcinoma Cells ◽  
Human Carcinoma ◽  
Radiation Induced

scholarly journals Improvement of nonviral p53 gene transfer in human carcinoma cells using glucosylated polyethylenimine derivatives

2001 ◽  
Vol 8 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Jean-Louis Merlin ◽  
Gilles Dolivet ◽  
Christophe Dubessy ◽  
Estelle Festor ◽  
Robert-Michel Parache ◽  
...  
Keyword(s):  
Gene Transfer ◽  
P53 Gene ◽  
Carcinoma Cells ◽  
Human Carcinoma

scholarly journals Cytotoxicity of naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells

2019 ◽  
Vol 10 (3) ◽  
pp. 178-184 ◽  
Author(s):  
Victor Kuete ◽  
Leonidah K. Omosa ◽  
Jacob O. Midiwo ◽  
Oğuzhan Karaosmanoğlu ◽  
Hülya Sivas
Keyword(s):  
Carcinoma Cells ◽  
Human Carcinoma ◽  
Naturally Occurring

scholarly journals IL-4, a direct target of miR-340/429, is involved in radiation-induced aggressive tumor behavior in human carcinoma cells

Oncotarget ◽  
2016 ◽  
Vol 7 (52) ◽  
pp. 86836-86856 ◽  
Author(s):  
Eun Sook Kim ◽  
Young Eun Choi ◽  
Su Jin Hwang ◽  
Young-Hoon Han ◽  
Myung-Jin Park ◽  
...  
Keyword(s):  
Carcinoma Cells ◽  
Human Carcinoma ◽  
Radiation Induced ◽  
Aggressive Tumor ◽  
Direct Target
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