Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells

2012 ◽  
Vol 27 (6) ◽  
pp. 885-891 ◽  
Author(s):  
Jing Tong ◽  
Shutao Yin ◽  
Yinhui Dong ◽  
Xiao Guo ◽  
Lihong Fan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Autophagic Cell Death ◽  
Prostate Cancer Cells ◽  
Pseudolaric Acid B

Neuregulin promotes autophagic cell death of prostate cancer cells

The Prostate ◽  
2003 ◽  
Vol 55 (2) ◽  
pp. 147-157 ◽  
Author(s):  
Pazit Tal-Or ◽  
Ayelet Di-Segni ◽  
Zipora Lupowitz ◽  
Ronit Pinkas-Kramarski
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Autophagic Cell Death ◽  
Prostate Cancer Cells

scholarly journals PKM2 Knockdown Induces Autophagic Cell Death via the AKT/mTOR Pathway in Human Prostate Cancer Cells

2019 ◽  
Author(s):  
Prasanta Dey ◽  
Amit Kundu ◽  
Richa Sachan ◽  
Jaehyun Park ◽  
Mee Young Ahn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Cancer Metabolism ◽  
Aerobic Glycolysis ◽  
Autophagic Cell Death ◽  
Prostate Cancer Cells ◽  
Glucose Transporter 1 ◽  
Acridine Orange Staining ◽  
Cancer Tissues

Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis and is highly expressed in various cancer tissues. Although high PKM2 expression is observed in prostate cancer tissues, its functional role in cancer metabolism is unclear. Here, we investigated the role of PKM2 in regulating autophagy and its associated pathways in prostate cancer cells. PKM2 expression was silenced using various PKM2 small interfering RNAs (siRNAs) and then we measured PKM2-related cellular pathways associated with autophagy. PKM2 siRNA-transfected prostate cancer cells showed significantly reduced viability. Acridine orange staining and immunoblotting analysis showed that PKM2 downregulation markedly increased autophagic cell death. Results of western blotting analysis showed that PKM2 knockdown affected protein kinase B/mechanistic target of rapamycin 1 pathway, which consequently downregulated the expression of glycolytic enzymes lactate dehydrogenase A and glucose transporter 1. To the best of our knowledge, this is the first study to show that PKM2 inhibition alters cancer cell metabolism and induces autophagy. Thus, the present study provides a strategy for the development of PKM2-targeted novel anticancer drugs for the treatment of prostate cancer.

scholarly journals Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway

2015 ◽  
Vol 55 (5) ◽  
pp. 818-831 ◽  
Author(s):  
Senthil Selvaraj ◽  
Yuyang Sun ◽  
Pramod Sukumaran ◽  
Brij B. Singh
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Mtor Pathway ◽  
Autophagic Cell Death ◽  
Prostate Cancer Cells

744 ZOLEDRONIC ACID INDUCES AUTOPHAGIC CELL DEATH IN HUMAN PROSTATE CANCER CELLS

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Yi-Chia Lin ◽  
Ji-Fan Lin ◽  
Te-Fu Tsai ◽  
Kuang-Yu Chou ◽  
Hung-En Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Zoledronic Acid ◽  
Cancer Cells ◽  
Autophagic Cell Death ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells
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