Preventive Effects of Hesperidin, Glucosyl Hesperidin and Naringin on Hypertension and Cerebral Thrombosis in Stroke-prone Spontaneously Hypertensive Rats

2012 ◽  
Vol 26 (9) ◽  
pp. 1272-1277 ◽  
Author(s):  
Miyako Ikemura ◽  
Yasuto Sasaki ◽  
John C. Giddings ◽  
Junichiro Yamamoto
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Cerebral Thrombosis ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Preventive Effects

scholarly journals Preventive Effects of Shichimotsu-koka-to on Renal Lesions in Stroke-Prone Spontaneously Hypertensive Rats.

1998 ◽  
Vol 21 (9) ◽  
pp. 914-918 ◽  
Author(s):  
Yukito HIGUCHI ◽  
Kageyoshi ONO ◽  
Setsuko SEKITA ◽  
Hiroshi ONODERA ◽  
Kunitoshi MITSUMORI ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Renal Lesions ◽  
Preventive Effects

Protective Effects of Imidapril on He-Ne Laser-Induced Thrombosis in Cerebral Blood Vessels of Stroke-Prone Spontaneously Hypertensive Rats

2000 ◽  
Vol 83 (05) ◽  
pp. 722-727 ◽  
Author(s):  
Takanori Noguchi ◽  
Junji Seki ◽  
J. C. Giddings ◽  
Junichiro Yamamoto ◽  
Yasuto Sasaki
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Blood Vessels ◽  
Spontaneously Hypertensive Rats ◽  
Protective Effects ◽  
Cerebral Thrombosis ◽  
Cerebral Blood Vessels ◽  
Hypertensive Rats ◽  
Concurrent Administration ◽  
Spontaneously Hypertensive

SummaryInhibitors of angiotensin converting enzyme (ACE) have been developed recently for therapeutic purposes in hypertension and ischemic cardiovascular diseases. Ogiku et al. (1) reported that one such inhibitor, imidapril, significantly prolonged survival in stroke-prone spontaneously hypertensive rats (SHRSP). The present study was designed to investigate the effect of imidapril on cerebral blood vessels in SHRSP to clarify role of the ACE inhibitor in mechanisms of cerebral thrombosis and stroke. Imidapril was administered orally at 1.0 and 5.0 mg/kg/day for 3 weeks from the age of 7 weeks, and was shown to prevent the usual increase in blood pressure seen in these animals. It also delayed He-Ne laser-induced cerebral thrombosis and increased significantly the plasma concentration of nitric oxide metabolites (NO2/NO3). To confirm the association between nitric oxide (NO) and these effects of imidapril, an inhibitor of nitric oxide synthase, NG - nitro-L-arginine methyl ester hydrochloride (L-NAME) was dissolved in drinking water and administered to the animals for 3 weeks. Four of six rats died from stroke when L-NAME was given alone. When imidapril (5.0 mg/kg/day) was administered with L-NAME, however, the animals showed no signs or symptoms of stroke. In these instances, therefore, the concurrent administration of L-NAME with imidapril reversed significantly the effects of imidapril. Intravenous injection of imidaprilat (100 µg/kg), an active metabolite of imidapril, also decreased blood pressure significantly and increased the plasma levels of NO2/NO3 after 5 min. Moreover, imidaprilat enlarged arteriolar diameters and caused an increase in red cell velocity and mean blood flow in pial arterioles after 15 min.The results strongly suggested that imidapril protects cerebral vessels in SHRSP by elevating the release of NO, thereby improving the cerebral circulation and reducing the tendency to thrombosis and stroke.

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