Role of peritoneal macrophages and lymphocytes in the development of hypogonadal osteoporosis in an ovariectomized rat model: possible phytoestrogenic efficacy of oil extract of garlic to preserve skeletal health

2007 ◽  
Vol 21 (11) ◽  
pp. 1045-1054 ◽  
Author(s):  
M. Mukherjee ◽  
A. S. Das ◽  
D. Das ◽  
S. Mukherjee ◽  
S. Mitra ◽  
...  
Keyword(s):  
Rat Model ◽  
Peritoneal Macrophages ◽  
Ovariectomized Rat ◽  
Skeletal Health ◽  
Oil Extract

Nonprotective role of losartan in cisplatin-induced nephrotoxicity in ovariectomized rat model treated with estradiol

2015 ◽  
Vol 6 (1) ◽  
pp. 2 ◽  
Author(s):  
Mehdi Nematbakhsh ◽  
Shahla Roozbehani ◽  
Safoora Mazaheri ◽  
Ardeshir Talebi ◽  
Zahra Pezeshki ◽  
...  
Keyword(s):  
Rat Model ◽  
Ovariectomized Rat

Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway

2018 ◽  
Vol 55 (10) ◽  
pp. 8188-8202 ◽  
Author(s):  
Ahmed S. Kamel ◽  
Noha F. Abdelkader ◽  
Sahar S. Abd El-Rahman ◽  
Marwan Emara ◽  
Hala F. Zaki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Akt Pathway ◽  
Stimulation Of

The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors

2020 ◽  
Vol 142 ◽  
pp. 111441
Author(s):  
Amira M. Abo-Youssef ◽  
Waleed A. Khallaf ◽  
Mahmoud M. Khattab ◽  
Basim A.S. Messiha
Keyword(s):  
Estrogen Receptors ◽  
Rat Model ◽  
Ovariectomized Rat

scholarly journals Microenvironmental changes by placenta-derived mesenchymal stem cells restore the ovarian function in ovariectomized rat via activated PI3K-FOXO3 pathway

2020 ◽  
Author(s):  
Jong Ho Choi ◽  
Jin Seok ◽  
Seung Mook Lim ◽  
Tae Hee Kim ◽  
Gi Jin Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Ovarian Function ◽  
Therapeutic Potential ◽  
Ovariectomized Rat ◽  
Expression Of Genes ◽  
Ovarian Folliculogenesis ◽  
Ovary Function

Abstract Background: Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, the mechanistic studies of the function of these cells have been insufficient. As ovarian failures cause anovulation as well as ovarian steroid hormonal unbalances, the specific aims of this study were to analyze the therapeutic role of placenta derived MSCs (PD-MSCs) in an ovarian-failure ovariectomy (OVX) rat model and evaluate whether PD-MSCs transplantation (Tx) improved folliculogenesis and oocyte maturation in the injured ovary through PI3K/Akt and FOXO signaling. Methods: Blood and ovary tissue were collected and analyzed after various PD-MSCs Tx treatments in the ovariectomized rat model. Changes in the expression of folliculogenesis and ovary regeneration-related genes due to PD-MSCs treatments were analyzed by qRT-PCR, Western blotting, and histological analysis. Results: The levels of hormones related to ovary function were significantly increased in the PD-MSCs Tx groups compared with those of the non-transplantation group (NTx). The follicle numbers in the ovarian tissues were increased along with increased expression of genes related to folliculogenesis for PD-MSCs Tx compared with NTx groups. Furthermore, PD-MSCs Tx induced maturation of follicles by increasing the phosphorylation of GSK3 beta and FOXO3 (p<0.05) and shifting the balance of growth and apoptosis in the oocytes. Conclusions: Taken together, PD-MSCs Tx can restore the ovarian function as well as induce ovarian folliculogenesis via the PI3K/Akt and FOXO signaling pathway.

scholarly journals Microenvironmental changes by placenta-derived mesenchymal stem cells restore the ovarian function in ovariectomized rat via activated PI3K-FOXO3 pathway

2020 ◽  
Author(s):  
Jong Ho Choi ◽  
Jin Seok ◽  
Seung Mook Lim ◽  
Tae Hee Kim ◽  
Gi Jin Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rat Model ◽  
Ovarian Function ◽  
Therapeutic Potential ◽  
Ovariectomized Rat ◽  
Expression Of Genes ◽  
Ovarian Folliculogenesis ◽  
Ovary Function

Abstract Background: Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, the mechanistic studies of the function of these cells have been insufficient. As ovarian failures cause anovulation as well as ovarian steroid hormonal unbalances, the specific aims of this study were to analyze the therapeutic role of placenta derived MSCs (PD-MSCs) in an ovarian-failure ovariectomy (OVX) rat model and evaluate whether PD-MSCs transplantation (Tx) improved folliculogenesis and oocyte maturation in the injured ovary through PI3K/Akt and FOXO signaling. Methods: Blood and ovary tissue were collected and analyzed after various PD-MSCs Tx treatments in the ovariectomized rat model. Changes in the expression of folliculogenesis and ovary regeneration-related genes due to PD-MSCs treatments were analyzed by qRT-PCR, Western blotting, and histological analysis. Results: The levels of hormones related to ovary function were significantly increased in the PD-MSCs Tx groups compared with those of the non-transplantation group (NTx). The follicle numbers in the ovarian tissues were increased along with increased expression of genes related to folliculogenesis for PD-MSCs Tx compared with NTx groups. Furthermore, PD-MSCs Tx induced maturation of follicles by increasing the phosphorylation of GSK3 beta and FOXO3 (p<0.05) and shifting the balance of growth and apoptosis in the oocytes. Conclusions: Taken together, PD-MSCs Tx can restore the ovarian function as well as induce ovarian folliculogenesis via the PI3K/Akt and FOXO signaling pathway.

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