The role of antioxidant system in gastroprotective action of camomile (Matricaria recutita L.) oil extract in stress induced stomach mucous ulceration

2004 ◽  
Author(s):  
V. G. Makarov ◽  
M. N. Makarova ◽  
A. E. Alexandrova ◽  
V. E. Ryzhenkov
Keyword(s):  
Antioxidant System ◽  
Matricaria Recutita ◽  
Oil Extract ◽  
Gastroprotective Action

Mechanisms of plant adaptation to hypothermia: role of antioxidant system

2018 ◽  
Vol 2018 (1) ◽  
pp. 6-33 ◽  
Author(s):  
Yu. Е. Kolupaev ◽  
◽  
Е. I. Gorelova ◽  
Т. О. Yastreb ◽  
◽  
...  
Keyword(s):  
Antioxidant System ◽  
Plant Adaptation

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

2017 ◽  
Vol 6 (9) ◽  
pp. 5474 ◽  
Author(s):  
Basant Mahmoud Morsy ◽  
Ghada Mohamed Safwat ◽  
Doaa Ahmed Hussein ◽  
Reem Mohamed Samy
Keyword(s):  
Valproic Acid ◽  
Nigella Sativa ◽  
Liver Lipid ◽  
Black Cumin ◽  
Enzymatic Antioxidant ◽  
Nigella Sativa Oil ◽  
Active Chemical ◽  
Oil Extract ◽  
Liver Lipid Peroxidation

Nigella sativa (NS), commonly known as black cumin, has been used for medicinal purposes. Traditionally the seeds and its oil are used in several diseases. The greatest part of the remedial properties of this plant is due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil. The current study performed to evaluate the effect of Nigella sativa Oil (NSO) extract on the neurotoxic and hepatotoxic potentials from Valproic acid (VPA) administration. Also we summarize recent findings emphasizing the role of main neurotoxic and hepatotoxic markers and oxidative stress in study’s case. Neurotoxicity was induced by VPA at dose of (500 mg/kg b.wt) by gastric intubation daily for 30 day. These rats received NSO extract was given orally at dose of (0.5 ml/kg b.wt) daily for 30 days after VPA administration. The current results revealed that NSO extract treatment ameliorated significantly the elevated levels of the neurotoxic and hepatotoxic biomarkers which elevated as a result to VPA administration. Moreover, NSO extract treatment ameliorated the non-enzymatic antioxidant, brain and liver lipid peroxidation (LPO) and glutathione (GSH) concentration and the enzymatic antioxidant, brain and liver catalase(CAT) activity.

Modulatory Role of Glutathione Monoester in Augmenting Age-Associated Neuronal Antioxidant System

2008 ◽  
Vol 34 (4) ◽  
pp. 419-436 ◽  
Author(s):  
Ganesan Murali ◽  
Chinnakkannu Panneerselvam
Keyword(s):  
Antioxidant System

scholarly journals Oxidative stress in animals: a pathophysiologist's view

2020 ◽  
Vol 2020 (4) ◽  
pp. 10-18
Author(s):  
Dmitriy Gildikov
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Antioxidant System ◽  
Review Article ◽  
Publication Activity ◽  
Pathophysiological Mechanism ◽  
Oxygen Species ◽  
The World ◽  
Intracellular Oxidative Stress

In the review article, from the modern standpoint, oxidative stress is considered as a universal pathophysiological mechanism of the vast majority of diseases in animals. A brief review of the publication activity in the world on this topic; the significance of reactive oxygen species in the physiology and development of intracellular oxidative stress, the role of etiological factors that initiate their hyperproduction are presented, as well the methods of detecting oxidative stress are characterizited. General concepts of the antioxidant system of the animal body are examined, and the pathophysiological targets of oxidative stress in animals are generalized.

scholarly journals The role of the antioxidant: Selenopyran in the stability of the antioxidant system to toxic effect of cadmium chloride

2007 ◽  
Vol 23 (5-6-1) ◽  
pp. 181-191
Author(s):  
U. Kravchenko ◽  
G. Borjaev ◽  
M. Nevitov ◽  
A. Ostapchuk ◽  
E. Kistanova
Keyword(s):  
Oxidative Stress ◽  
Antioxidant System ◽  
Antioxidant Defense ◽  
Age Groups ◽  
Selenium Concentration ◽  
Antioxidant Defense System ◽  
The Stability ◽  
Gpx Activity ◽  
Preventive Role

The purpose of the present work was, under conditions of the model experiment on rats, to tap the information about the features of shortterm acclimatization of the antioxidant system in various organs to toxicity of cadmium at stages of an ontogenesis and about the preventive role of the antioxidant selenopyran in this process. The obtained results showed the ontogenetic differences in the adaptive reactivity of the enzymatic antioxidant defense system in the most important organs and tissues of rats under conditions of oxidative stress induced by cadmium. The ontogenetic differences of Se redistribution in a body under influence of cadmium administration were found. The discovered decrease of Se concentration in the liver of young animals and the increase of its concentration in the liver of old animals correlated positively with the changes of GPx activity. Preventive administration of selenopyran (9- phenyl-simmetrical octa-hydroselenoxanthene) to old animals reduced the oxidative stress intensity. Animals of all age groups showed higher selenium concentration in the tissues and the increase in the selenium-dependent GPx activity.

scholarly journals Ethylene Induction of Non-Enzymatic Metabolic Antioxidants in Matricaria chamomilla

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5720
Author(s):  
Veronika Petrulova ◽  
Maria Vilkova ◽  
Zuzana Kovalikova ◽  
Matus Sajko ◽  
Miroslav Repcak
Keyword(s):  
Antioxidant System ◽  
Therapeutic Effects ◽  
Enzymatic Antioxidants ◽  
Matricaria Chamomilla ◽  
Chlorogenic Acids ◽  
Isolation And Identification ◽  
Phytochemical Content ◽  
Enzymatic Antioxidant ◽  
Dicaffeoylquinic Acid

Phytochemical investigations of Matricaria chamomilla L. (Asteraceae) stated the presence of several compounds with an established therapeutic and antioxidant potential. The chamomile non-enzymatic antioxidant system includes low molecular mass compounds, mainly polyphenols such as cinnamic, hydroxybenzoic and chlorogenic acids, flavonoids and coumarins. The objective of this work was to evaluate the role of the non-enzymatic antioxidant system after stimulation by ethylene in tetraploid chamomile plants. Seven days of ethylene treatment significantly increased the activity of phenylalanine ammonia-lyase, which influenced the biosynthesis of protective polyphenols in the first step of their biosynthetic pathway. Subsequently, considerable enhanced levels of phenolic metabolites with a substantial antioxidant effect (syringic, vanillic and caffeic acid, 1,5-dicaffeoylquinic acid, quercetin, luteolin, daphnin, and herniarin) were determined by HPLC-DAD-MS. The minimal information on the chlorogenic acids function in chamomile led to the isolation and identification of 5-O-feruloylquinic acid. It is accumulated during normal conditions, but after the excessive effect of abiotic stress, its level significantly decreases and levels of other caffeoylquinic acids enhance. Our results suggest that ethephon may act as a stimulant of the production of pharmaceutically important non-enzymatic antioxidants in chamomile leaves and thus, lead to an overall change in phytochemical content and therapeutic effects of chamomile plants, as well.

Invertebrate responses to microplastic ingestion: Reviewing the role of the antioxidant system

2020 ◽  
Vol 734 ◽  
pp. 138559 ◽  
Author(s):  
Charlene Trestrail ◽  
Dayanthi Nugegoda ◽  
Jeff Shimeta
Keyword(s):  
Antioxidant System

Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance

2008 ◽  
Vol 260 (1-2) ◽  
pp. 96-108 ◽  
Author(s):  
Jeong-Min Cho ◽  
Sarala Manandhar ◽  
Hyang-Rim Lee ◽  
Hyun-Min Park ◽  
Mi-Kyoung Kwak
Keyword(s):  
Cancer Cell ◽  
Antioxidant System ◽  
Cell Resistance
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