Analogs of arginine vasopressin modified in theN-terminal part of the molecule with a conformationally constrainedcis-peptide bond motif

2007 ◽  
Vol 13 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Dariusz Sobolewski ◽  
Adam Prahl ◽  
Izabela Derdowska ◽  
Jiřina Slaninová ◽  
Krzysztof Kaczmarek ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Peptide Bond ◽  
Terminal Part

Analogues of Neurohypophyseal Hormones, Oxytocin and Arginine Vasopressin, Conformationally Restricted in the N-Terminal Part of the Molecule

2006 ◽  
Vol 49 (6) ◽  
pp. 2016-2021 ◽  
Author(s):  
Wioleta Kowalczyk ◽  
Adam Prahl ◽  
Izabela Derdowska ◽  
Dariusz Sobolewski ◽  
Jadwiga Olejnik ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Terminal Part ◽  
Conformationally Restricted ◽  
Neurohypophyseal Hormones

The Effects of N-Terminal Part Modification of Arginine Vasopressin Analogues with 2-Aminoindane-2-carboxylic Acid:  A Highly Potent V2Agonist

2007 ◽  
Vol 50 (12) ◽  
pp. 2926-2929 ◽  
Author(s):  
Wioleta Kowalczyk ◽  
Dariusz Sobolewski ◽  
Adam Prahl ◽  
Izabela Derdowska ◽  
Lenka Borovičková ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Arginine Vasopressin ◽  
Terminal Part ◽  
Vasopressin Analogues

Synthesis and Some Pharmacological Properties of Six New Analogs of Arginine-Vasopressin Substituted in Position 2 with β-Thienylalanine or Prolonged on the N-Terminus with 1-Adamantaneacetic Acid

1993 ◽  
Vol 58 (12) ◽  
pp. 2994-2999 ◽  
Author(s):  
Ewa Konieczna ◽  
Malgorzata Czaja ◽  
Bernard Lammek ◽  
Jiřina Slaninová ◽  
Tomislav Barth
Keyword(s):  
Arginine Vasopressin ◽  
Peptide Bond ◽  
Pharmacological Properties ◽  
N Terminus

Six new analogs of arginine-vasopressin, four of them substituted in position 2 with β-thienylalanine and two prolonged on the n-terminus by acylation with 1-adamantaneacetic acid, were synthesized on chloromethylated resin using Boc strategy and DCC or DCC-HOBt to form peptide bond. The activity of the analogs was fairly low, however, one of the peptides, namely [Cpp1, Thi2, Val4]AVP, showed selectivity in antiuterotonic, antipressor and anti-antidiuretic effects.

Effect of N-methylation of the peptide bond in the C-terminal part of the B-chain of human insulin on biological activity

2001 ◽  
Author(s):  
Lenka Klasová ◽  
Štefan Zorad ◽  
Jiří Velek ◽  
Jan Ježek ◽  
Václav Kašička ◽  
...  
Keyword(s):  
Biological Activity ◽  
Human Insulin ◽  
Peptide Bond ◽  
Terminal Part

Analogues of arginine vasopressin and its agonist and antagonist modified in the N-terminal part of the molecule with l-beta-homophenylalanine

2005 ◽  
Vol 65 (4) ◽  
pp. 465-471
Author(s):  
D. Sobolewski ◽  
W. Kowalczyk ◽  
A. Prahl ◽  
I. Derdowska ◽  
J. Slaninova ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Terminal Part ◽  
Agonist And Antagonist

Analogues of AVP modified in the N -terminal part of the molecule with Pip isomers: TFA-catalysed peptide bond hydrolysis

2008 ◽  
Vol 15 (3) ◽  
pp. 161-165 ◽  
Author(s):  
Dariusz Sobolewski ◽  
Adam Prahl ◽  
Anna Kwiatkowska ◽  
Jiřina Slaninová ◽  
Bernard Lammek
Keyword(s):  
Peptide Bond ◽  
Terminal Part

Tryptic splitting of vasopressin analogues containing homologues of lysine or arginine in position 8

1979 ◽  
Vol 44 (8) ◽  
pp. 2451-2454
Author(s):  
Anastasia Dimeli ◽  
Tomislav Barth
Keyword(s):  
Amino Acid ◽  
Arginine Vasopressin ◽  
Basic Amino Acid ◽  
Peptide Bond ◽  
Peptide Chain ◽  
Side Chain ◽  
Lysine Vasopressin ◽  
Vasopressin Analogues

Vasopressin analogues containing an amino acid with a shorter side chain in position 8 of the peptide chain were more resistant to tryptic splitting of the peptide bond formed by the basic amino acid and terminal glycine amide. In the lysine vasopressin series, analogues with ornithine or lower homologues of lysine in position 8 were not hydrolyzed. In the arginine vasopressin series, the analogue containing 3-guanidino-2-aminopropionic acid in position 8 was completely resistant to the action of trypsin. The vasopressin analogue with norarginine in position 8 was split at a lower rate than natural arginine vasopressin.

Analogues of arginine vasopressin modified in the N-terminal part of the molecule with enantiomers of N-methylphenylalanine

2004 ◽  
Vol 63 (5) ◽  
pp. 420-425 ◽  
Author(s):  
W. Kowalczyk ◽  
I. Derdowska ◽  
O. Dawidowska ◽  
A. Prahl ◽  
B. Hartrodt ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Terminal Part
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