In vitroandin vivocharacterization of an interleukin-15 antagonist peptide by metabolic stability,99mTc-labeling, and biological activity assays

2018 ◽  
Vol 24 (4-5) ◽  
pp. e3078 ◽  
Author(s):  
Yunier Rodríguez-Álvarez ◽  
Ania Cabrales-Rico ◽  
Alejandro Perera-Pintado ◽  
Anais Prats-Capote ◽  
Hilda E. Garay-Pérez ◽  
...  
Keyword(s):  
Biological Activity ◽  
Metabolic Stability ◽  
Interleukin 15 ◽  
99Mtc Labeling

Inhibitors of cytosolic phospholipase A2α with carbamate structure: synthesis, biological activity, metabolic stability, and bioavailability

2014 ◽  
Vol 23 (12) ◽  
pp. 5250-5262 ◽  
Author(s):  
Julian Schwarzkopf ◽  
Tom Sundermann ◽  
Martina Arnsmann ◽  
Walburga Hanekamp ◽  
Jörg Fabian ◽  
...  
Keyword(s):  
Biological Activity ◽  
Metabolic Stability ◽  
Cytosolic Phospholipase ◽  
Structure Synthesis ◽  
Cytosolic Phospholipase A2α

ω-Imidazolyl- and ω-Tetrazolylalkylcarbamates as Inhibitors of Fatty Acid Amide Hydrolase: Biological Activity and in vitro Metabolic Stability

ChemMedChem ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. 429-443 ◽  
Author(s):  
Tobias Terwege ◽  
Walburga Hanekamp ◽  
David Garzinsky ◽  
Simone König ◽  
Oliver Koch ◽  
...  
Keyword(s):  
Biological Activity ◽  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Metabolic Stability ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Expression of bovine interleukin 15 in Pichia pastoris and study on its biological activity: a T-cell activator

2019 ◽  
Vol 31 (4) ◽  
pp. 357-364
Author(s):  
N. Vijay ◽  
J. Lijo ◽  
S. Barathiraja ◽  
P. A. V. Gangadhara ◽  
H. J. Dechamma ◽  
...  
Keyword(s):  
Biological Activity ◽  
T Cell ◽  
Pichia Pastoris ◽  
Interleukin 15 ◽  
Cell Activator

scholarly journals Expression of bovine interleukin 15 and evaluation of its biological activity in vitro

2015 ◽  
Vol 8 (3) ◽  
pp. 295-300 ◽  
Author(s):  
N. Vijay ◽  
J. Lijo ◽  
H. J. Dechamma ◽  
V. Bhanuprakash ◽  
B. Suresh ◽  
...  
Keyword(s):  
Biological Activity ◽  
Interleukin 15

scholarly journals Increasing the bioactive space of peptide macrocycles by thioamide substitution

2018 ◽  
Vol 9 (9) ◽  
pp. 2443-2451 ◽  
Author(s):  
Hitesh Verma ◽  
Bhavesh Khatri ◽  
Sohini Chakraborti ◽  
Jayanta Chatterjee
Keyword(s):  
Biological Activity ◽  
Metabolic Stability ◽  
Conformational Rigidity ◽  
Macrocyclic Peptides

Thioamide substitution into macrocyclic peptides increases the conformational rigidity of the backbone resulting in enhanced biological activity and metabolic stability.

Novel glycosylated VIP analogs: synthesis, biological activity, and metabolic stability

2008 ◽  
Vol 14 (3) ◽  
pp. 321-328 ◽  
Author(s):  
David Dangoor ◽  
Barbara Biondi ◽  
Marina Gobbo ◽  
Yelena Vachutinski ◽  
Mati Fridkin ◽  
...  
Keyword(s):  
Biological Activity ◽  
Metabolic Stability

Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification

2006 ◽  
Vol 14 (5) ◽  
pp. 1309-1330 ◽  
Author(s):  
Satoshi Komoriya ◽  
Shozo Kobayashi ◽  
Ken Osanai ◽  
Toshiharu Yoshino ◽  
Tsutomu Nagata ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Metabolic Stability ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Ligand Modification

scholarly journals Macrolactam analogues of macrolide natural products

2016 ◽  
Vol 14 (48) ◽  
pp. 11301-11316 ◽  
Author(s):  
Helmut M. Hügel ◽  
Andrew T. Smith ◽  
Mark A. Rizzacasa
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Chemical Modification ◽  
Metabolic Stability

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity.

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