scholarly journals DNA-modified artificial viral capsids self-assembled from DNA-conjugatedβ-annulus peptide

2017 ◽  
Vol 23 (7-8) ◽  
pp. 636-643 ◽  
Author(s):  
Yoko Nakamura ◽  
Saki Yamada ◽  
Shoko Nishikawa ◽  
Kazunori Matsuura
Keyword(s):  
Viral Capsids ◽  
Self Assembled

Packaging of DNA origami in viral capsids

Nanoscale ◽  
2019 ◽  
Vol 11 (21) ◽  
pp. 10160-10166 ◽  
Author(s):  
Idit Kopatz ◽  
Ran Zalk ◽  
Yael Levi-Kalisman ◽  
Efrat Zlotkin-Rivkin ◽  
Gabriel A. Frank ◽  
...  
Keyword(s):  
Dna Origami ◽  
Medical Applications ◽  
Viral Capsids ◽  
New Type ◽  
Self Assembled

DNA origami in self-assembled SV40 capsid, a new type of encapsulation substrate for medical applications.

Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer

2020 ◽  
Vol 56 (52) ◽  
pp. 7092-7095
Author(s):  
Hiroto Furukawa ◽  
Hiroshi Inaba ◽  
Fumihito Inoue ◽  
Yoshihiro Sasaki ◽  
Kazunari Akiyoshi ◽  
...  
Keyword(s):  
Lipid Bilayer ◽  
Self Assembly ◽  
Cationic Lipid ◽  
Viral Capsid ◽  
Viral Capsids ◽  
Simple Strategy ◽  
Self Assembled

We demonstrated a simple strategy for constructing enveloped artificial viral capsids by self-assembly of anionic artificial viral capsid and lipid bilayer containing cationic lipid.

Self-Assembled Synthetic Viral Capsids from a 24-mer Viral Peptide Fragment

2010 ◽  
Vol 122 (50) ◽  
pp. 9856-9859 ◽  
Author(s):  
Kazunori Matsuura ◽  
Kenta Watanabe ◽  
Tsubasa Matsuzaki ◽  
Kazuo Sakurai ◽  
Nobuo Kimizuka
Keyword(s):  
Peptide Fragment ◽  
Viral Capsids ◽  
Viral Peptide ◽  
Self Assembled

Self-Assembled Synthetic Viral Capsids from a 24-mer Viral Peptide Fragment

2010 ◽  
Vol 49 (50) ◽  
pp. 9662-9665 ◽  
Author(s):  
Kazunori Matsuura ◽  
Kenta Watanabe ◽  
Tsubasa Matsuzaki ◽  
Kazuo Sakurai ◽  
Nobuo Kimizuka
Keyword(s):  
Peptide Fragment ◽  
Viral Capsids ◽  
Viral Peptide ◽  
Self Assembled

scholarly journals Self-assembled artificial viral capsids bearing coiled-coils at the surface

2017 ◽  
Vol 15 (23) ◽  
pp. 5070-5077 ◽  
Author(s):  
Seiya Fujita ◽  
Kazunori Matsuura
Keyword(s):  
Coiled Coil ◽  
Coiled Coils ◽  
Viral Capsid ◽  
Viral Capsids ◽  
Self Assembled

A β-annulus-coiled-coil-B peptide self-assembled into an artificial viral capsid and then the addition of a complementary coiled-coil-A peptide showed the formation of capsids with coiled-coil spikes on the surface.

scholarly journals Self-assembly of Ni-NTA-modified β-annulus peptides into artificial viral capsids and encapsulation of His-tagged proteins

2016 ◽  
Vol 14 (33) ◽  
pp. 7869-7874 ◽  
Author(s):  
Kazunori Matsuura ◽  
Tomohiro Nakamura ◽  
Kenta Watanabe ◽  
Takanori Noguchi ◽  
Kosuke Minamihata ◽  
...  
Keyword(s):  
Self Assembly ◽  
Viral Capsids ◽  
Self Assembled

His-tagged proteins were encapsulated into artificial viral capsids self-assembled from Ni-NTA-modified β-annulus peptides.

scholarly journals Anomalous Elastic Properties of Attraction-Dominated DNA Self-Assembled 2D Films and the Resultant Dynamic Biodetection Signals of Microbeam Sensors

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 543 ◽  
Author(s):  
Junzheng Wu ◽  
Ying Zhang ◽  
Nenghui Zhang
Keyword(s):  
Elastic Properties ◽  
Physical Mechanism ◽  
Dynamic Instability ◽  
Viral Capsids ◽  
Double Stranded Dna ◽  
Highly Sensitive ◽  
Dynamic Analyses ◽  
Self Assembled ◽  
Dna Films ◽  
Tensile Surface

The condensation of DNA helices has been regularly found in cell nucleus, bacterial nucleoids, and viral capsids, and during its relevant biodetections the attractive interactions between DNA helices could not be neglected. In this letter, we theoretically characterize the elastic properties of double-stranded DNA (dsDNA) self-assembled 2D films and their multiscale correlations with the dynamic detection signals of DNA-microbeams. The comparison of attraction- and repulsion-dominated DNA films shows that the competition between attractive and repulsive micro-interactions endows dsDNA films in multivalent salt solutions with anomalous elastic properties such as tensile surface stresses and negative moduli; the occurrence of the tensile surface stress for the attraction-dominated DNA self-assembled film reveals the possible physical mechanism of the condensation found in organism. Furthermore, dynamic analyses of a hinged–hinged DNA-microbeam reveal non-monotonous frequency shifts due to attraction- or repulsion-dominated dsDNA adsorptions and dynamic instability occurrence during the detections of repulsion-dominated DNA films. This dynamic instability implies the existence of a sensitive interval of material parameters in which DNA adsorptions will induce a drastic natural frequency shift or a jump of vibration mode even with a tiny variation of the detection conditions. These new insights might provide us some potential guidance to achieve an ultra-highly sensitive biodetection method in the future.

scholarly journals A Photoresponsive Artificial Viral Capsid Self-Assembled from an Azobenzene-Containing β-Annulus Peptide

2021 ◽  
Vol 22 (8) ◽  
pp. 4028
Author(s):  
Kazunori Matsuura ◽  
Seiya Fujita
Keyword(s):  
Uv Irradiation ◽  
Structural Changes ◽  
Solid Phase ◽  
Viral Capsid ◽  
Trans Form ◽  
Peptide Backbone ◽  
Viral Capsids ◽  
Azobenzene Moiety ◽  
Self Assembled ◽  
Peptide Materials

Photoinduced structural changes in peptides can dynamically control the formation and dissociation of supramolecular peptide materials. However, the existence of photoresponsive viral capsids in nature remains unknown. In this study, we constructed an artificial viral capsid possessing a photochromic azobenzene moiety on the peptide backbone. An azobenzene-containing β-annulus peptide derived from the tomato bushy stunt virus was prepared through solid-phase synthesis using Fmoc-3-[(3-aminomethyl)-phenylazo]phenylacetic acid. The azobenzene-containing β-annulus (β-Annulus-Azo) peptide showed a reversible trans/cis isomerization property. The β-annulus-azo peptide self-assembled at 25 μM into capsids with the diameters of 30–50 nm before UV irradiation (trans-form rich), whereas micrometer-sized aggregates were formed after UV irradiation (cis-form rich). The artificial viral capsid possessing azobenzene facilitated the encapsulation of fluorescent-labeled dextrans and their photoinduced release from the capsid.

Sign in / Sign up

Export Citation Format

Share Document