Biodegradable paclitaxel-loaded microparticles prepared from novel block copolymers: influence of polymer composition on drug encapsulation and release

2013 ◽  
Vol 19 (4) ◽  
pp. 205-213 ◽  
Author(s):  
Susanna Sartori ◽  
Andrea Caporale ◽  
Alfonsina Rechichi ◽  
Domenico Cufari ◽  
Caterina Cristallini ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Polymer Composition ◽  
Drug Encapsulation

scholarly journals Amphiphilic block copolymers from a renewable ε-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release

2016 ◽  
Vol 4 (44) ◽  
pp. 7119-7129 ◽  
Author(s):  
Deepak Kakde ◽  
Vincenzo Taresco ◽  
Kuldeep K. Bansal ◽  
E. Peter Magennis ◽  
Steven M. Howdle ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Drug Encapsulation ◽  
Micellar Core

Block co-polymers with a block derived from a sustainable monomer source are used to encapsulate and release the drug indomethacin.

PEG coated vesicles from mixtures of Pluronic P123 and l-α-phosphatidylcholine: structure, rheology and curcumin encapsulation

2017 ◽  
Vol 19 (39) ◽  
pp. 26821-26832 ◽  
Author(s):  
Bijaideep Dutta ◽  
K. C. Barick ◽  
Gunjan Verma ◽  
V. K. Aswal ◽  
Inbar Freilich ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Coated Vesicles ◽  
Drug Encapsulation ◽  
Pluronic P123

PEGylated vesicles from co-assembly of block copolymers and lipids for drug encapsulation.

scholarly journals The Influence of Polymer Composition on the Hydrolytic and Enzymatic Degradation of Polyesters and Their Block Copolymers with PDMAEMA

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3636
Author(s):  
Maria Kupczak ◽  
Anna Mielańczyk ◽  
Dorota Neugebauer
Keyword(s):  
Block Copolymers ◽  
Enzymatic Degradation ◽  
Degradation Kinetics ◽  
Hydrolytic Degradation ◽  
Polymer Composition ◽  
Amphiphilic Copolymers ◽  
Solution Ph ◽  
Aliphatic Polyesters ◽  
Dimethylaminoethyl Methacrylate

Well-defined, semi-degradable polyester/polymethacrylate block copolymers, based on ε-caprolactone (CL), d,l-lactide (DLLA), glycolide (GA) and N,N′-dimethylaminoethyl methacrylate (DMAEMA), were synthesized by ring-opening polymerization (ROP) and atom transfer radical polymerization. Comprehensive degradation studies of poly(ε-caprolactone)-block-poly(N,N′-dimethylaminoethyl methacrylate) (PCL-b-PDMAEMA) on hydrolytic degradation and enzymatic degradation were performed, and those results were compared with the corresponding aliphatic polyester (PCL). The solution pH did not affect the hydrolytic degradation rate of PCL (a 3% Mn loss after six weeks). The presence of a PDMAEMA component in the copolymer chain increased the hydrolysis rates and depended on the solution pH, as PCL-b-PDMAEMA degraded faster in an acidic environment (36% Mn loss determined) than in a slightly alkaline environment (27% Mn loss). Enzymatic degradation of PCL-b-PDMAEMA, poly(d,l-lactide)-block-poly(N,N′-dimethylaminoethyl methacrylate) (PLA-b-PDMAEMA) and poly(lactide-co-glycolide-co-ε-caprolactone)-block-poly(N,N′-dimethylaminoethyl methacrylate) (PLGC-b-PDMAEMA) and the corresponding aliphatic polyesters (PCL, PLA and PLGC) was performed by Novozyme 435. In enzymatic degradation, PLGC degraded almost completely after eleven days. For polyester-b-PDMAEMA copolymers, enzymatic degradation primarily involved the ester bonds in PDMAEMA side chains, and the rate of polyester degradation decreased with the increase in the chain length of PDMAEMA. Amphiphilic copolymers might be used for biomaterials with long-term or midterm applications such as nanoscale drug delivery systems with tunable degradation kinetics.

Block copolymers containing dextran and deoxycholic acid polyesters. Synthesis, self-assembly and hydrophobic drug encapsulation

2019 ◽  
Vol 223 ◽  
pp. 115118 ◽  
Author(s):  
Magdalena C. Stanciu ◽  
Marieta Nichifor ◽  
Georgeta Mocanu ◽  
Cristina Tuchilus ◽  
Gabriela L. Ailiesei
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Deoxycholic Acid ◽  
Hydrophobic Drug ◽  
Drug Encapsulation

Asphalt Modified by Partially Hydrogenated SBS Tri-Block Copolymers

2005 ◽  
Vol 78 (4) ◽  
pp. 620-643 ◽  
Author(s):  
M. A. Vargas ◽  
A. E. Chávez ◽  
R. Herrera ◽  
O. Manero
Keyword(s):  
High Temperature ◽  
Block Copolymers ◽  
Gel Permeation Chromatography ◽  
Mechanical Tests ◽  
Polymer Composition ◽  
Scanning Calorimetry ◽  
Styrene Butadiene Styrene ◽  
Hydrogenation Time ◽  
Styrene Butadiene ◽  
Butadiene Styrene

Abstract This work examines the modification of asphalt with hydrogenated poly (styrene-butadiene-styrene) copolymer containing different amounts of butadiene and ethylene-co-butylene. The polymer composition can be described generically as poly (styrene−[(butadiene)1−x−(ethylene−co−butylene)x]−styrene), where x is the hydrogenated fraction of the molecule. These hydrogenated (SBEBS) copolymers were produced by in-situ hydrogenation following a Ziegler-Natta catalytic reaction of poly (styrene-butadiene-styrene) tri-block copolymers (SBS), which were previously synthesized by anionic polymerization. Control over the hydrogenation time produces SBEBS polymers with various degrees of saturation of the polybutadiene block, as characterized by FTIR, HNMR, differential scanning calorimetry (DSC) and gel permeation chromatography (GPC). Polymer-modified asphalts (PMA) were obtained by a high-temperature mixing process with AC-20 asphalt (Salamanca, Mexico) and SBS or SBEBS copolymers. PMA samples were characterized before and after high-temperature storage tests by fluorescence microscopy, rheometry, and mechanical tests. Results indicate that PMA obtained from SBEBS contain a polymer matrix with well-dispersed asphalt rich phase, with improved mechanical and thermal stability over those PMA produced with SBS. Compatibility between SBEBS and the aromatic fraction of maltenes can explain the dispersion of the polymer in asphalt and the enhanced properties.

PEO-b-PCL Block Copolymers: Synthesis, Detailed Characterization, and Selected Micellar Drug Encapsulation Behavior

2005 ◽  
Vol 26 (24) ◽  
pp. 1918-1924 ◽  
Author(s):  
Michael A. R. Meier ◽  
Sebastianus N. H. Aerts ◽  
Bastiaan B. P. Staal ◽  
Mircea Rasa ◽  
Ulrich S. Schubert
Keyword(s):  
Block Copolymers ◽  
Detailed Characterization ◽  
Drug Encapsulation

Polymersomes from Dual Responsive Block Copolymers: Drug Encapsulation by Heating and Acid-Triggered Release

2013 ◽  
Vol 14 (5) ◽  
pp. 1555-1563 ◽  
Author(s):  
Zeng-Ying Qiao ◽  
Ran Ji ◽  
Xiao-Nan Huang ◽  
Fu-Sheng Du ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Triggered Release ◽  
Drug Encapsulation ◽  
Dual Responsive
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