scholarly journals Prevention and treatment of age-related macular degeneration

Prescriber ◽  
2017 ◽  
Vol 28 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Sarah Horton ◽  
Catherine Guly
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Prevention And Treatment

scholarly journals Choroid-resident macrophages maintain local vasculature and RPE integrity and spontaneously regenerate following depletion

2019 ◽  
Author(s):  
Xiao Yang ◽  
Lian Zhao ◽  
Maria M. Campos ◽  
Mones Abu-Asab ◽  
Davide Ortolan ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Angiogenic Factor ◽  
Pigment Epithelial ◽  
Age Related ◽  
Prevention And Treatment ◽  
Factor Expression ◽  
Choroidal Vasculature

AbstractThe choroid of the eye provides necessary vascular supply to the outer retina across the retinal pigment epithelial (RPE) layer and is a locus of progressive degenerative change in aging and age-related macular degeneration (AMD). Cellular mechanisms that maintain or compromise choroidal vasculature homeostasis are not well understood, complicating therapeutic efforts. We discover here that pharmacological ablation of macrophages normally resident in the adult mouse choroid via blockade of the CSF1 receptor resulted in progressive thinning of the choroid layer and atrophy of the choriocapillaris. Concurrently, choroidal macrophage ablation also induced structural disorganization of the RPE cell layer, downregulation of RPE visual cycle genes, and altered RPE angiogenic factor expression. Suspension of CSF1R blockade following ablation conversely enabled spontaneous regeneration of the choroidal macrophage population, restoring original macrophage distribution and morphological features. Macrophage repopulation significantly ameliorated the ablation-induced changes in RPE structure and angiogenic factor expression and arrested choroidal vascular atrophy. These findings reveal a previously unsuspected trophic function of resident choroidal macrophages in the maintenance of choroidal vasculature and the RPE layer, suggesting that insufficiency of macrophage function may contribute to age- and AMD-associated pathology. Modulating choroidal macrophage support function can constitute a strategy for therapeutic preservation of the choroid and RPE in AMD prevention and treatment.Significance StatementChoroidal atrophy is associated with normal aging and progression in age-related macular degeneration (AMD), a leading cause of blindness. Herein, we identify the choroidal macrophage as a critical player in the homeostatic maintenance of choroid-RPE complex of the eye. Depletion of choroidal macrophages resulted in progressive vascular atrophy, altered structure of retinal pigment epithelial (RPE) cells, and dysregulated RPE expression of visual cycle protein and angiogenic factors, VEGF and PEDF. We discovered that choroidal macrophages can regenerate and repopulate the choroid following depletion, ameliorating RPE alterations and arresting vascular atrophy. Our results suggest that insufficiency of macrophage function may contribute to age- and AMD-associated pathology, and modulation of macrophage support functions may be therapeutically useful in AMD prevention and treatment.

scholarly journals Revisión Bibliográfica: Degeneración Macular Relacionada con la Edad. Prevención y Tratamiento Temprano

2018 ◽  
Vol 10 (2) ◽  
pp. 145-149
Author(s):  
Katerine Leonor Ávila Heras ◽  
Yadira Karina Carrillo Mora ◽  
Sofía Nathaly Cely Jadan ◽  
Marisa Arcos
Keyword(s):  
Folic Acid ◽  
Macular Degeneration ◽  
Health Personnel ◽  
Age Related Macular Degeneration ◽  
World Health ◽  
Central Vision ◽  
Age Related ◽  
The World ◽  
Prevention And Treatment ◽  
Health Organization

Age-related macular degeneration is one of the diseases that affect the macula in people over 50 years of age, due to the existence of different multifactorial neurodegenerative changes that can lead to the loss of central vision. According to the World Health Organization there is a prevalence of 4 % worldwide; it is related of 7 % of the blindness and 3 %; Clinically it is manifested by two forms, the atrophic or dry and the exudative or wet. It has been shown that foods rich in antioxidants, folic acid and zinc help reduce this disease in early stages. This review aims to update health personnel about the prevention and treatment of age-related macular degeneration.

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