Determination of residues of endosulfan in human blood by a negative ion chemical ionization gas chromatographic/mass spectrometric method: impact of long-term aerial spray exposure

2003 ◽  
Vol 59 (3) ◽  
pp. 252-258 ◽  
Author(s):  
Atmakuru Ramesh ◽  
Perumal Elumalai Ravi
Keyword(s):  
Human Blood ◽  
Chemical Ionization ◽  
Mass Spectrometric ◽  
Negative Ion ◽  
Spectrometric Method ◽  
Mass Spectrometric Method ◽  
Negative Ion Chemical Ionization ◽  
Chromatographic Mass

Gas-chromatographic/mass-spectrometric determination of theophylline in whole blood.

1977 ◽  
Vol 23 (1) ◽  
pp. 64-68 ◽  
Author(s):  
M Sheehan ◽  
R H Hertel ◽  
C T Kelly
Keyword(s):  
Coefficient Of Variation ◽  
Whole Blood ◽  
Mass Spectrometric ◽  
Spectrometric Method ◽  
Mass Spectrometric Method ◽  
Mass Spectrometric Determination ◽  
Pediatric Populations ◽  
Chromatographic Mass

Abstract We describe a combined gas-chromatographic mass-spectrometric method for determination of theophylline in whole blood. With use of a probability-based matching approach, the extensive gas-chromatographic interference did not affect mass-spectrometric quantitation of theophylline. Concentrations expected and found were linearly related from 1 to 60 mg/liter; the run-to-run coefficient of variation was less than 8%, within-run less than 6%. Some other xan-thines and drugs frequently co-administered with theophylline did not affect results. Only 0.2 ml of blood is required, which makes the procedure useful for monitoring theophylline in newborns and pediatric populations.

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