Reduced expression of the P‐glycoprotein gene PxABCB1 is linked to resistance to Bacillus thuringiensis Cry1Ac toxin in Plutella xylostella (L.)

2019 ◽  
Vol 76 (2) ◽  
pp. 712-720 ◽  
Author(s):  
Junlei Zhou ◽  
Zhaojiang Guo ◽  
Shi Kang ◽  
Jianying Qin ◽  
Lijun Gong ◽  
...  
Keyword(s):  
Bacillus Thuringiensis ◽  
Plutella Xylostella ◽  
Glycoprotein Gene ◽  
Cry1ac Toxin ◽  
P Glycoprotein

Survival, Weight Gain, and Oviposition of Resistant and Susceptible Plutella xylostella (Lepidoptera: Plutellidae) on Broccoli Expressing Cry1Ac Toxin of Bacillus thuringiensis

1999 ◽  
Vol 92 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Juliet D. Tang ◽  
Hilda L. Collins ◽  
Richard T. Roush ◽  
Timothy D. Metz ◽  
Elizabeth D. Earle ◽  
...  
Keyword(s):  
Weight Gain ◽  
Bacillus Thuringiensis ◽  
Plutella Xylostella ◽  
Cry1ac Toxin

scholarly journals Identification of members of the P-glycoprotein multigene family.

1989 ◽  
Vol 9 (3) ◽  
pp. 1224-1232 ◽  
Author(s):  
W F Ng ◽  
F Sarangi ◽  
R L Zastawny ◽  
L Veinot-Drebot ◽  
V Ling
Keyword(s):  
Multidrug Resistance ◽  
Gene Duplication ◽  
Gene Family ◽  
Multigene Family ◽  
Rhesus Monkeys ◽  
Genomic Library ◽  
Duplication Event ◽  
Glycoprotein Gene ◽  
P Glycoprotein ◽  
Exon Probe

Overproduction of P-glycoprotein is intimately associated with multidrug resistance. This protein appears to be encoded by a multigene family. Thus, differential expression of different members of this family may contribute to the complexity of the multidrug resistance phenotype. Three lambda genomic clones isolated from a hamster genomic library represent different members of the hamster P-glycoprotein gene family. Using a highly conserved exon probe, we found that the hamster P-glycoprotein gene family consists of three genes. We also found that the P-glycoprotein gene family consists of three genes in mice but has only two genes in humans and rhesus monkeys. The hamster P-glycoprotein genes have similar exon-intron organizations within the 3' region encoding the cytoplasmic domains. We propose that the hamster P-glycoprotein gene family arose from gene duplication. The hamster pgp1 and pgp2 genes appear to be more closely related to each other than either gene is to the pgp3 gene. We speculate that the hamster pgp1 and pgp2 genes arose from a recent gene duplication event and that primates did not undergo this duplication and therefore contain only two P-glycoprotein genes.

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