scholarly journals Alteration of the soluble guanylate cyclase system in coronary arteries of high cholesterol diet‐fed rabbits

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
Masashi Tawa ◽  
Katsuya Nakano ◽  
Yuka Yamashita ◽  
Qiang He ◽  
Takayoshi Masuoka ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

Agonist-specific impairment of coronary vascular function in genetically altered, hyperlipidemic mice

1999 ◽  
Vol 276 (4) ◽  
pp. R1023-R1029 ◽  
Author(s):  
Kathryn G. Lamping ◽  
Daniel W. Nuno ◽  
David A. Chappell ◽  
Frank M. Faraci
Keyword(s):  
Nitric Oxide ◽  
Coronary Arteries ◽  
Guanylate Cyclase ◽  
Vascular Function ◽  
Soluble Guanylate Cyclase ◽  
Plasma Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Deficient Mice

The objectives of the present study were to 1) examine mechanisms involved in endothelium-dependent responses of coronary arteries from normal mice and 2) determine whether vascular responses of coronary arteries are altered in two genetic models of hypercholesterolemia [apolipoprotein E (apoE)-deficient mice (apoE −/−) and combined apoE and low-density lipoprotein receptor (LDLR)-deficient mice (apoE + LDLR −/−)]. Plasma cholesterol levels were higher in both apoE −/− and apoE + LDLR −/− compared with normal mice on normal and high-cholesterol diets (normal chow: normal 110 ± 5 mg/dl, apoE −/− 680 ± 40 mg/dl, apoE + LDLR −/− 810 ± 40 mg/dl; high-cholesterol chow: normal 280 ± 60 mg/dl, apoE −/− 2,490 ± 310 mg/dl, apoE + LDLR −/− 3,660 ± 290 mg/dl). Coronary arteries from normal (C57BL/6J), apoE −/−, and apoE + LDLR −/− mice were isolated and cannulated, and diameters were measured using videomicroscopy. In normal mice, vasodilation in response to ACh and serotonin was markedly reduced by 10 μM N ω-nitro-l-arginine (an inhibitor of nitric oxide synthase) or 20 μM 1 H-[1,2,4]oxadiazolo[4,3- a]quinoxalin-1-one (ODQ; an inhibitor of soluble guanylate cyclase). Vasodilation to nitroprusside, but not papaverine, was also inhibited by ODQ. Dilation of arteries from apoE −/− and apoE + LDLR −/− mice on normal diet in response to ACh was similar to that observed in normal mice. In contrast, dilation of arteries in response to serotonin from apoE −/− and apoE + LDLR −/− mice was impaired compared with normal. In arteries from both apoE −/− and apoE + LDLR −/− mice on high-cholesterol diet, dilation to ACh was decreased. In apoE + LDLR −/− mice on high-cholesterol diet, dilation of coronary arteries to nitroprusside was increased. These findings suggest that dilation of coronary arteries from normal mice in response to ACh and serotonin is dependent on production of nitric oxide and activation of soluble guanylate cyclase. Hypercholesterolemia selectively impairs dilator responses of mouse coronary arteries to serotonin. In the absence of both apoE and the LDL receptor, high levels of cholesterol result in a greater impairment in coronary endothelial function.

Reserpine inhibition of coronary arteriosclerosis

1969 ◽  
Vol 47 (1) ◽  
pp. 105-107 ◽  
Author(s):  
Oliver Carrier Jr. ◽  
B. R. Clower ◽  
Peggy Joyce Whittington-Coleman
Keyword(s):  
Coronary Arteries ◽  
Histological Study ◽  
Protective Action ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Coronary Arteriosclerosis ◽  
High Cholesterol

A histological study of rabbit hearts from animals on a high-cholesterol diet (2% by weight) supplemented with vasopressin administration (2–4 units, three times a week) showed that after 7 weeks this regimen caused coronary arteriosclerotic lesions in three out of five animals. At the end of 10 weeks, 95% of the coronary arteries observed in five out of five animals had signs of arteriosclerosis. When, in addition to this treatment, the rabbits received 0.1 mg/kg reserpine per day, the incidence and severity of the lesions were greatly reduced. At 7 weeks only 10%, and at 10 weeks only 26% of the coronary arteries observed showed arteriosclerotic changes. These data indicate that reserpine has a protective action against atheromatous lesions which may be associated with its calcium-depleting effect.

Hypolipidemic and antioxidant effect of Ajuga iva in rats fed a high-cholesterol diet

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
MA Lacaille-Dubois ◽  
A Chenni ◽  
DA Yahia ◽  
FO Boukortt ◽  
J Prost ◽  
...  
Keyword(s):  
Antioxidant Effect ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

Serum lipoproteins of diabetic rats fed a high cholesterol diet

Diabetes ◽  
1980 ◽  
Vol 29 (10) ◽  
pp. 774-777 ◽  
Author(s):  
C. M. Arbeeny ◽  
D. Edelstein ◽  
S. R. Freedman ◽  
H. A. Eder
Keyword(s):  
Diabetic Rats ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Serum Lipoproteins ◽  
High Cholesterol

Effect of Polygonum multiflorum Thunberg Extract on Lipid Metabolism in Rats Fed High-Cholesterol Diet

2012 ◽  
Vol 41 (7) ◽  
pp. 957-962 ◽  
Author(s):  
Jun-Hweok Choi ◽  
Hye-Sung Lee ◽  
Young-Eon Kim ◽  
Byoung-Mok Kim ◽  
In-Ho Kim ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Polygonum Multiflorum
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