Crystal structure of a chimera of human and plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization

2008 ◽  
Vol 73 (4) ◽  
pp. 1010-1020 ◽  
Author(s):  
P. Gayathri ◽  
I. N. Sujay Subbayya ◽  
Chethan S. Ashok ◽  
T. Senthamizh Selvi ◽  
Hemalatha Balaram ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum

Crystal Structure of Fully Ligated Adenylosuccinate Synthetase from Plasmodium falciparum

2004 ◽  
Vol 335 (5) ◽  
pp. 1251-1264 ◽  
Author(s):  
K. Eaazhisai ◽  
R. Jayalakshmi ◽  
P. Gayathri ◽  
R.P. Anand ◽  
K. Sumathy ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Adenylosuccinate Synthetase

scholarly journals Crystal Structure of the Plasmodium falciparum Apicoplast DNA Polymerase

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Morgan Milton ◽  
Richard Honzatko ◽  
Scott Nelson
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Dna Polymerase

scholarly journals The crystal structure of PfFabZ, the unique β-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum

2009 ◽  
Vol 14 (6) ◽  
pp. 1570-1580 ◽  
Author(s):  
Dirk Kostrewa ◽  
Fritz K. Winkler ◽  
Gerd Folkers ◽  
Leonardo Scapozza ◽  
Remo Perozzo
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Fatty Acid ◽  
Fatty Acid Biosynthesis ◽  
Acid Biosynthesis

scholarly journals Rational Design of Anticytoadherence Inhibitors for Plasmodium falciparum Based on the Crystal Structure of Human Intercellular Adhesion Molecule 1

2006 ◽  
Vol 50 (2) ◽  
pp. 724-730 ◽  
Author(s):  
Matthias Dormeyer ◽  
Yvonne Adams ◽  
Bernd Kramer ◽  
Srabasti Chakravorty ◽  
Man Tsuey Tse ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Binding Site ◽  
Adhesion Molecule ◽  
Rational Design ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Lymphocyte Function ◽  
Dependent Manner ◽  
Intercellular Adhesion Molecule 1

ABSTRACT Adhesion of Plasmodium falciparum-infected erythrocytes (IE) to host endothelium has been associated with pathology in malaria. Although the interaction with endothelial cells can be complex due to the relatively large number of host receptors available for binding, specific proteins have been identified that are more commonly used than others. For example, binding to intercellular adhesion molecule 1 (ICAM 1) is found frequently in parasites from pediatric cases of malaria. The binding site for P. falciparum-infected erythrocytes on ICAM 1 has been mapped in some detail and is distinct from the site for lymphocyte function-associated antigen 1 (LFA-1). Part of the ICAM 1 binding site for P. falciparum-infected erythrocytes (the DE loop) was used to screen a library of compounds based on its structure (derived from the crystal structure of human ICAM 1). This resulted in the identification of 36 structural mimeotopes as potential competitive inhibitors of binding. One of these compounds, (+)-epigalloyl-catechin-gallate [(+)-EGCG], was found to inhibit IE adhesion to ICAM 1 in a dose-dependent manner with two variant ICAM 1-binding parasite lines, providing the first example of a potential mimeotope-based anticytoadherence inhibitor for Plasmodium falciparum.

Synthesis of Novel Diazabicycles and their Antiprotozoal Activities

2009 ◽  
Vol 62 (9) ◽  
pp. 1166 ◽  
Author(s):  
Volker Wolkinger ◽  
Robert Weis ◽  
Ferdinand Belaj ◽  
Marcel Kaiser ◽  
Reto Brun ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Nmr Spectroscopy ◽  
Microwave Irradiation ◽  
Crystal Structure Analysis ◽  
East African ◽  
Bicyclic System ◽  
African Form ◽  
New Compounds ◽  
Single Crystal Structure Analysis

We describe the synthesis of new diaryl substituted diazabicyclo[3.2.1]octanes from diazepanes which were prepared by the reduction of diazepanones. The formation of the bicyclic system was optimized by microwave irradiation and the structures of the new compounds were established by single crystal structure analysis and NMR spectroscopy. All new compounds were tested for their potencies against Plasmodium falciparum K1 and Trypanosoma b. rhodesiense, the causative organisms of malaria tropica and the East African form of sleeping sickness.

Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase–Thioredoxin Complex

2013 ◽  
Vol 425 (18) ◽  
pp. 3446-3460 ◽  
Author(s):  
Karin Fritz-Wolf ◽  
Esther Jortzik ◽  
Michaela Stumpf ◽  
Janina Preuss ◽  
Rimma Iozef ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Thioredoxin Reductase

scholarly journals Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum

2012 ◽  
Vol 178 (1) ◽  
pp. 61-73 ◽  
Author(s):  
Jürgen Bosch ◽  
Matthew H. Paige ◽  
Akhil B. Vaidya ◽  
Lawrence W. Bergman ◽  
Wim G.J. Hol
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Inner Membrane ◽  
Membrane Complex ◽  
Inner Membrane Complex
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