Synthesis of Novel Diazabicycles and their Antiprotozoal Activities

2009 ◽  
Vol 62 (9) ◽  
pp. 1166 ◽  
Author(s):  
Volker Wolkinger ◽  
Robert Weis ◽  
Ferdinand Belaj ◽  
Marcel Kaiser ◽  
Reto Brun ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Plasmodium Falciparum ◽  
Nmr Spectroscopy ◽  
Microwave Irradiation ◽  
Crystal Structure Analysis ◽  
East African ◽  
Bicyclic System ◽  
African Form ◽  
New Compounds ◽  
Single Crystal Structure Analysis

We describe the synthesis of new diaryl substituted diazabicyclo[3.2.1]octanes from diazepanes which were prepared by the reduction of diazepanones. The formation of the bicyclic system was optimized by microwave irradiation and the structures of the new compounds were established by single crystal structure analysis and NMR spectroscopy. All new compounds were tested for their potencies against Plasmodium falciparum K1 and Trypanosoma b. rhodesiense, the causative organisms of malaria tropica and the East African form of sleeping sickness.

Ein zweikerniger Vanadium(V)-Komplex mit (μ1)- und (μ-μ2:μ2)-gebundenen Hydrazido(2-)-Liganden / A Dinuclear Vanadium(V) Com plex with (μ1)- and (μ-μ2:μ2)-Bonded Hydrazido(2-) Ligands

1996 ◽  
Vol 51 (12) ◽  
pp. 1675-1678 ◽  
Author(s):  
Klaus Kopka ◽  
Rainer Mattes
Keyword(s):  
Crystal Structure ◽  
Nmr Spectroscopy ◽  
Single Crystal ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Title Complex ◽  
Metal Centers ◽  
Bond Lengths ◽  
Bridging Ligand ◽  
Single Crystal Structure Analysis

The title complex was obtained by reaction of guanidinium dioxodipicolinatovanadate(V) and N-methyl-N-phenylhydrazine. According to the single crystal structure analysis the dinuclear anion [(μ-PhNNH)(μ-OCH3){(MePhNN(dipic)V)}2]- with sevenfold coordinated metal centers contains two types of hydrazido ligands. The ligand [MePhNN]2- is terminally bonded, and the VNN unit is linear with extensive electron delocalisation. The V-N and N-N bond lengths are 167.9(5) and 131.9(6) pm, respectively. The bonding of the bridging ligand is of the hitherto unknown μ-μ2:μ2 type, with V-N and N-N bond lengths of 202.5(5) and 136.5(5) pm, respectively. The V(N2)V moiety is not planar. The compound was also characterized by 1H and 51V NMR spectroscopy.

Stimuli-Responsive Luminescent Supramolecular Assemblies and Co-assemblies by Orthogonal Dipole-Dipole Interaction and Halogen Bonding

2021 ◽  
Author(s):  
Akshoy Jamadar ◽  
Ajeet Kumar Singh ◽  
Lisa Roy ◽  
Anindita Das
Keyword(s):  
Crystal Structure ◽  
Single Crystal ◽  
Structure Analysis ◽  
Halogen Bonding ◽  
Dipole Interaction ◽  
Crystal Structure Analysis ◽  
Supramolecular Assemblies ◽  
Single Crystal Structure ◽  
Stimuli Responsive ◽  
Single Crystal Structure Analysis

This article reports π-chromophore assemblies from three structurally related dipolar naphthalene monoimide (NMI) luminogens (M1, M2 and M3) by underexplored orthogonal dipole-dipole interaction and halogen bonding. Single crystal structure analysis...

Methansulfinylchlorid-Lewissäure-Addukte CH3S(Cl)OMF5 (M = As, Sb) und Kristallstruktur von CH3S(Cl)OSbCl5 [1] / Methanesulfinylchloride Lewis Acid Adducts CH3S(Cl)OMF5 (M = As, Sb) and Crystal Structure of CH3S(Cl)OSbCl5 [1]

1996 ◽  
Vol 51 (1) ◽  
pp. 133-138 ◽  
Author(s):  
Rolf Minkwitz ◽  
Ulrike Lohmann ◽  
Hans Preut
Keyword(s):  
Crystal Structure ◽  
Nmr Spectroscopy ◽  
Lewis Acid ◽  
Unit Cell ◽  
Monoclinic Space Group ◽  
Space Group ◽  
New Compounds ◽  
Lewis Acid Adducts

Abstract CH3S(0)C1 reacts in HF as solvent with MF5 (M = As, Sb) to give products CH3S(Cl)OMF5 (M = As, Sb). The new compounds are stable below 253 K and were charac­ terized by Raman and NMR spectroscopy.In addition, the crystal structure of CH3S(Cl)OSbCl5 has been determinated. The complex crystallizes in the monoclinic space group P21/n with a = 644.3(5), b = 1905.9(14), c = 900.0(7) pm, β = 99.27(6)° with four formula units per unit cell.

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