Oxygen affinity controlled by dynamical distal conformations: The soybean leghemoglobin and the Paramecium caudatum hemoglobin cases

2007 ◽  
Vol 68 (2) ◽  
pp. 480-487 ◽  
Author(s):  
Marcelo A. Martí ◽  
Luciana Capece ◽  
Damián E. Bikiel ◽  
Bruno Falcone ◽  
Darío A Estrin
Keyword(s):  
Oxygen Affinity ◽  
Paramecium Caudatum ◽  
Soybean Leghemoglobin

Determination of interdependent ligand effects on human red cell oxygen affinity

1982 ◽  
Vol 42 (4) ◽  
pp. 339-345
Author(s):  
W. G. Zijlstra ◽  
B. Oeseburg ◽  
G. Kwant ◽  
A. Zwart
Keyword(s):  
Oxygen Affinity ◽  
Red Cell ◽  
Ligand Effects

EFFECT OF BW12C ON OXYGEN AFFINITY OF HAEMOGLOBIN IN SICKLE-CELL DISEASE

The Lancet ◽  
1986 ◽  
Vol 327 (8485) ◽  
pp. 831-834 ◽  
Author(s):  
A.J. Keidan ◽  
R.D. White ◽  
E.R. Huehns ◽  
I.M. Franklin ◽  
M. Joy ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Oxygen Affinity ◽  
Cell Disease

scholarly journals Molecular Pathways Involved in the Development of Congenital Erythrocytosis

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1150
Author(s):  
Jana Tomc ◽  
Nataša Debeljak
Keyword(s):  
Signal Transduction ◽  
Iron Homeostasis ◽  
Molecular Mechanisms ◽  
Oxygen Affinity ◽  
Molecular Pathways ◽  
Disease Development ◽  
Post Translational Modifications ◽  
Hemoglobin Oxygen Affinity ◽  
Insight Into ◽  
Idiopathic Erythrocytosis

Patients with idiopathic erythrocytosis are directed to targeted genetic testing including nine genes involved in oxygen sensing pathway in kidneys, erythropoietin signal transduction in pre-erythrocytes and hemoglobin-oxygen affinity regulation in mature erythrocytes. However, in more than 60% of cases the genetic cause remains undiagnosed, suggesting that other genes and mechanisms must be involved in the disease development. This review aims to explore additional molecular mechanisms in recognized erythrocytosis pathways and propose new pathways associated with this rare hematological disorder. For this purpose, a comprehensive review of the literature was performed and different in silico tools were used. We identified genes involved in several mechanisms and molecular pathways, including mRNA transcriptional regulation, post-translational modifications, membrane transport, regulation of signal transduction, glucose metabolism and iron homeostasis, which have the potential to influence the main erythrocytosis-associated pathways. We provide valuable theoretical information for deeper insight into possible mechanisms of disease development. This information can be also helpful to improve the current diagnostic solutions for patients with idiopathic erythrocytosis.

scholarly journals Kinetics and thermodynamics of oxygen, CO, and azide binding by the subcomponents of soybean leghemoglobin.

1990 ◽  
Vol 265 (32) ◽  
pp. 19588-19593
Author(s):  
K D Martin ◽  
L Saari ◽  
G X Wang ◽  
T Wang ◽  
L J Parkhurst ◽  
...  
Keyword(s):  
Kinetics And Thermodynamics ◽  
Azide Binding ◽  
Soybean Leghemoglobin

Hemoglobin fort gordon or α2β2145 Tyr → Asp, a new high-oxygen-affinity hemoglobin variant

1975 ◽  
Vol 400 (2) ◽  
pp. 343-347 ◽  
Author(s):  
H.B. Kleckner ◽  
J.B. Wilson ◽  
J.G. Lindeman ◽  
P.D. Stevens ◽  
G. Niazi ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
High Oxygen ◽  
Hemoglobin Variant ◽  
High Oxygen Affinity
Sign in / Sign up

Export Citation Format

Share Document