Cis/trans isomerization in HIV-1 capsid protein catalyzed by cyclophilin A: Insights from computational and theoretical studies

2004 ◽  
Vol 56 (3) ◽  
pp. 449-463 ◽  
Author(s):  
Pratul K. Agarwal
Keyword(s):  
Capsid Protein ◽  
Cyclophilin A ◽  
Theoretical Studies ◽  
Trans Isomerization ◽  
Hiv 1

scholarly journals Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein

2008 ◽  
Vol 6 (11) ◽  
pp. 2297-2307 ◽  
Author(s):  
Felix F. Vajdos ◽  
Sanghee Yoo ◽  
Megan Houseweart ◽  
Wesley I. Sundquist ◽  
Christopher P. Hill
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Capsid Protein ◽  
Cyclophilin A ◽  
Hiv 1

HIV-1 Capsid Protein and Cyclophilin A as New Targets for Anti-AIDS Therapeutic Agents

2007 ◽  
Vol 7 (3) ◽  
pp. 238-244 ◽  
Author(s):  
Jiebo Li ◽  
Shixing Tang ◽  
Indira Hewlett ◽  
Ming Yang
Keyword(s):  
Capsid Protein ◽  
Cyclophilin A ◽  
Therapeutic Agents ◽  
New Targets ◽  
Hiv 1

scholarly journals Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

Retrovirology ◽  
2007 ◽  
Vol 4 (1) ◽  
pp. 19 ◽  
Author(s):  
Samir Abdurahman ◽  
Stefan Höglund ◽  
Anders Höglund ◽  
Anders Vahlne
Keyword(s):  
Binding Site ◽  
Capsid Protein ◽  
Virus Assembly ◽  
Cyclophilin A ◽  
Hiv 1

scholarly journals Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A

2002 ◽  
Vol 99 (8) ◽  
pp. 5247-5252 ◽  
Author(s):  
D. A. Bosco ◽  
E. Z. Eisenmesser ◽  
S. Pochapsky ◽  
W. I. Sundquist ◽  
D. Kern
Keyword(s):  
Cyclophilin A ◽  
Trans Isomerization ◽  
Hiv 1

Design of a Gag Pentapeptide Analogue that Binds Human Cyclophilin A More Efficiently than the Entire Capsid Protein:  New Insights for the Development of Novel Anti-HIV-1 Drugs†

2000 ◽  
Vol 43 (9) ◽  
pp. 1770-1779 ◽  
Author(s):  
Quan Li ◽  
Mireille Moutiez ◽  
Jean-Baptiste Charbonnier ◽  
Karine Vaudry ◽  
André Ménez ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Cyclophilin A ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals An extensive thermodynamic characterization of the dimerization domain of the HIV-1 capsid protein

2005 ◽  
Vol 14 (9) ◽  
pp. 2387-2404 ◽  
Author(s):  
María C. Lidón-Moya ◽  
Francisco N. Barrera ◽  
Marta Bueno ◽  
Raúl Pérez-Jiménez ◽  
Javier Sancho ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Dimerization Domain ◽  
Thermodynamic Characterization ◽  
Hiv 1

scholarly journals Structure, Function, and Interactions of the HIV-1 Capsid Protein

Life ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 100
Author(s):  
Eric Rossi ◽  
Megan E. Meuser ◽  
Camille J. Cunanan ◽  
Simon Cocklin
Keyword(s):  
Life Cycle ◽  
Capsid Protein ◽  
Adaptor Proteins ◽  
Restriction Factors ◽  
Gag Polyprotein ◽  
Immunodeficiency Virus ◽  
Host Cell Factors ◽  
Hiv 1

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential structural component of a virion and facilitates many crucial life cycle steps through interactions with host cell factors. Capsid shields the reverse transcription complex from restriction factors while it enables trafficking to the nucleus by hijacking various adaptor proteins, such as FEZ1 and BICD2. In addition, the capsid facilitates the import and localization of the viral complex in the nucleus through interaction with NUP153, NUP358, TNPO3, and CPSF-6. In the later stages of the HIV-1 life cycle, CA plays an essential role in the maturation step as a constituent of the Gag polyprotein. In the final phase of maturation, Gag is cleaved, and CA is released, allowing for the assembly of CA into a fullerene cone, known as the capsid core. The fullerene cone consists of ~250 CA hexamers and 12 CA pentamers and encloses the viral genome and other essential viral proteins for the next round of infection. As research continues to elucidate the role of CA in the HIV-1 life cycle and the importance of the capsid protein becomes more apparent, CA displays potential as a therapeutic target for the development of HIV-1 inhibitors.

scholarly journals Solid-State NMR Studies of HIV-1 Capsid Protein Assemblies

2010 ◽  
Vol 132 (6) ◽  
pp. 1976-1987 ◽  
Author(s):  
Yun Han ◽  
Jinwoo Ahn ◽  
Jason Concel ◽  
In-Ja L. Byeon ◽  
Angela M. Gronenborn ◽  
...  
Keyword(s):  
Solid State ◽  
Capsid Protein ◽  
Solid State Nmr ◽  
Protein Assemblies ◽  
Nmr Studies ◽  
Hiv 1
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