scholarly journals Crystal structure of a phosphotransacetylase from Streptococcus pyogenes

2004 ◽  
Vol 55 (2) ◽  
pp. 479-481 ◽  
Author(s):  
Qian Steven Xu ◽  
Dong-Hae Shin ◽  
Ramona Pufan ◽  
Hisao Yokota ◽  
Rosalind Kim ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Streptococcus Pyogenes

scholarly journals Crystal Structure of Streptococcus pyogenes Cas1 and Its Interaction with Csn2 in the Type II CRISPR-Cas System

Structure ◽  
2016 ◽  
Vol 24 (1) ◽  
pp. 70-79 ◽  
Author(s):  
Donghyun Ka ◽  
Hasup Lee ◽  
Yi-Deun Jung ◽  
Kyunggon Kim ◽  
Chaok Seok ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Streptococcus Pyogenes ◽  
Type Ii

Crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes

2007 ◽  
Vol 68 (4) ◽  
pp. 1016-1019 ◽  
Author(s):  
Won-Ho Lee ◽  
Young Kwan Kim ◽  
Ki Hyun Nam ◽  
Amit Priyadarshi ◽  
Eun Hye Lee ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Adenosine Deaminase ◽  
Streptococcus Pyogenes

scholarly journals Structural and Biochemical Studies of Dihydrofolate Reductase from Streptococcus pyogenes as a Target for Antifolate Antibiotics

2018 ◽  
Author(s):  
Behnoush Hajian ◽  
Jolanta Krucinska ◽  
Michael Martins ◽  
Narendran G-Dayanan ◽  
Kishore Viswanathan ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Streptococcus Pyogenes ◽  
Dihydrofolate Reductase ◽  
Wide Spectrum ◽  
Streptococcal Infections ◽  
Biochemical Studies ◽  
Live Bacteria ◽  
Dhfr Inhibitors ◽  
First Time ◽  
Structural Insights

ABSTRACTStreptococcus pyogenes, a beta-hemolytic bacterium, causes a wide spectrum of infections in human including pharyngitis, tonsillitis, scarlet fever, rheumatic fever, and necrotizing fasciitis. Streptococcal infections can also exist as co-infection with methicillin resistant Staphylococcus aureus (MRSA). Trimethoprim-sulfamethoxazole (TMP-SMX) combination has been used for treatment of S. pyogenes and MRSA co-infection. However, resistance to TMP, an inhibitor of dihydrofolate reductase enzyme (DHFR), has challenged the efficacy of TMP-SMX combination. We explored the activity of a series of novel DHFR inhibitors against S. pyogenes. This study identified potent inhibitors of DHFR enzyme from S. pyogenes with excellent inhibitory activity against the growth of the live bacteria. We determined, for the first time, the crystal structure of S. pyogenes DHFR which provides structural insights into design and development of antifolate agents against this global pathogen.

scholarly journals Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies

2014 ◽  
Vol 111 (18) ◽  
pp. 6714-6719 ◽  
Author(s):  
B. Trastoy ◽  
J. V. Lomino ◽  
B. G. Pierce ◽  
L. G. Carter ◽  
S. Gunther ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Streptococcus Pyogenes ◽  
Igg Antibodies ◽  
Human Igg

Crystal structure of ω transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 Å resolution 1 1Edited by R. Huber

2001 ◽  
Vol 314 (4) ◽  
pp. 789-796 ◽  
Author(s):  
Kazutaka Murayama ◽  
Peter Orth ◽  
Ana B de la Hoz ◽  
Juan C Alonso ◽  
Wolfram Saenger
Keyword(s):  
Crystal Structure ◽  
Streptococcus Pyogenes ◽  
Transcriptional Repressor

Model for Substrate Interactions in C5a Peptidase from Streptococcus pyogenes: A 1.9 Å Crystal Structure of the Active Form of ScpA

2009 ◽  
Vol 386 (3) ◽  
pp. 754-772 ◽  
Author(s):  
Todd F. Kagawa ◽  
Maurice R. O'Connell ◽  
Pania Mouat ◽  
Max Paoli ◽  
Paul W. O'Toole ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Streptococcus Pyogenes ◽  
Active Form ◽  
Substrate Interactions

scholarly journals Crystal Structure of Spy0129, a Streptococcus pyogenes Class B Sortase Involved in Pilus Assembly

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e15969 ◽  
Author(s):  
Hae Joo Kang ◽  
Fasséli Coulibaly ◽  
Thomas Proft ◽  
Edward N. Baker
Keyword(s):  
Crystal Structure ◽  
Streptococcus Pyogenes ◽  
Class B ◽  
Pilus Assembly

Crystal Structure Determination of Glycerol-Containing Lipids from Electron Diffraction Data. Use of Analog Compounds Based upon Configurational Isomers of Cyclopentane-1, 2, 3-TRIOL

1977 ◽  
Vol 35 ◽  
pp. 24-25
Author(s):  
Douglas L. Dorset ◽  
Anthony J. Hancock
Keyword(s):  
Crystal Structure ◽  
Electron Diffraction ◽  
Diffraction Data ◽  
Structure Determination ◽  
Crystal Surface ◽  
Coherent Scattering ◽  
Crystal Structure Determination ◽  
Electron Diffraction Data ◽  
Polar Group ◽  
Axis Orientation

Lipids containing long polymethylene chains were among the first compounds subjected to electron diffraction structure analysis. It was only recently realized, however, that various distortions of thin lipid microcrystal plates, e.g. bends, polar group and methyl end plane disorders, etc. (1-3), restrict coherent scattering to the methylene subcell alone, particularly if undistorted molecular layers have well-defined end planes. Thus, ab initio crystal structure determination on a given single uncharacterized natural lipid using electron diffraction data can only hope to identify the subcell packing and the chain axis orientation with respect to the crystal surface. In lipids based on glycerol, for example, conformations of long chains and polar groups about the C-C bonds of this moiety still would remain unknown.One possible means of surmounting this difficulty is to investigate structural analogs of the material of interest in conjunction with the natural compound itself. Suitable analogs to the glycerol lipids are compounds based on the three configurational isomers of cyclopentane-1,2,3-triol shown in Fig. 1, in which three rotameric forms of the natural glycerol derivatives are fixed by the ring structure (4-7).

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