Role of maximal androgen blockade in advanced prostate cancer

The Prostate ◽  
1994 ◽  
Vol 25 (S1) ◽  
pp. 17-22 ◽  
Author(s):  
Louis Denis
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Maximal Androgen Blockade ◽  
Androgen Blockade

Maximal androgen blockade for advanced prostate cancer

1999 ◽  
Author(s):  
Brian Schmitt ◽  
Charles Bennett ◽  
Jerome Seidenfeld ◽  
David Samson ◽  
Timothy J Wilt
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Maximal Androgen Blockade ◽  
Androgen Blockade

scholarly journals Maximal androgen blockade for advanced prostate cancer

2010 ◽  
Vol 26 (1) ◽  
pp. 133
Author(s):  
RajivPaul Mukha ◽  
Santosh Kumar ◽  
NS Kekre
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Maximal Androgen Blockade ◽  
Androgen Blockade

scholarly journals Role of maximum androgen blockade in advanced prostate cancer

2009 ◽  
Vol 25 (1) ◽  
pp. 47 ◽  
Author(s):  
Rajinikanth Ayyathurai ◽  
RoselyDe Los Santos ◽  
Murugesan Manoharan
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Androgen Blockade

Alternative Nonsteroidal Antiandrogen Therapy for Advanced Prostate Cancer That Relapsed After Initial Maximum Androgen Blockade

2008 ◽  
Vol 180 (3) ◽  
pp. 921-927 ◽  
Author(s):  
Hiroyoshi Suzuki ◽  
Koji Okihara ◽  
Hideaki Miyake ◽  
Masato Fujisawa ◽  
Susumu Miyoshi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Antiandrogen Therapy ◽  
Androgen Blockade

scholarly journals The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Carolina Soekmadji ◽  
Colleen C. Nelson
Keyword(s):  
Prostate Cancer ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Advanced Prostate Cancer ◽  
Control Cell ◽  
Extracellular Vesicle ◽  
Multidrug Resistance Proteins ◽  
Acquired Drug Resistance ◽  
Resistance Proteins

Emerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs.

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