Pharmacokinetics and PET imaging properties of two recombinant anti-PSMA antibody fragments in comparison to their parental antibody

The Prostate ◽  
2014 ◽  
Vol 74 (7) ◽  
pp. 743-755 ◽  
Author(s):  
Stefan Wiehr ◽  
Patrick Bühler ◽  
Dorothee Gierschner ◽  
Philipp Wolf ◽  
Anna-Maria Rolle ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Antibody Fragments ◽  
Parental Antibody ◽  
Imaging Properties

PET imaging of PD-L1 expression in NSCLC: Pharmacokinetic and dosimetric comparison of full antibody and associated antibody fragments

2020 ◽  
Vol 44 (2) ◽  
pp. 116
Author(s):  
A. Bouleau ◽  
H. Nozach ◽  
M. Richard ◽  
S. Dubois ◽  
B. Kuhnast ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Antibody Fragments ◽  
Dosimetric Comparison

scholarly journals Increase in negative charge of 68Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sara S. Rinne ◽  
Charles Dahlsson Leitao ◽  
Joshua Gentry ◽  
Bogdan Mitran ◽  
Ayman Abouzayed ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Negative Charge ◽  
Human Cancer ◽  
Hepatic Uptake ◽  
Common Mechanism ◽  
Affibody Molecules ◽  
Her3 Expression ◽  
Gallium 68 ◽  
Imaging Properties

AbstractUpregulation of the human epidermal growth factor receptor type 3 (HER3) is a common mechanism to bypass HER-targeted cancer therapy. Affibody-based molecular imaging has the potential for detecting and monitoring HER3 expression during treatment. In this study, we compared the imaging properties of newly generated 68Ga-labeled anti-HER3 affibody molecules (HE)3-ZHER3-DOTA and (HE)3-ZHER3-DOTAGA with previously reported [68Ga]Ga-(HE)3-ZHER3-NODAGA. We hypothesized that increasing the negative charge of the gallium-68/chelator complex would reduce hepatic uptake, which could lead to improved contrast of anti-HER3 affibody-based PET-imaging of HER3 expression. (HE)3-ZHER3-X (X = DOTA, DOTAGA) were produced and labeled with gallium-68. Binding of the new conjugates was specific in HER3 expressing BxPC-3 and DU145 human cancer cells. Biodistribution and in vivo specificity was studied in BxPC-3 xenograft bearing Balb/c nu/nu mice 3 h pi. DOTA- and DOTAGA-containing conjugates had significantly higher concentration in blood than [68Ga]Ga-(HE)3-ZHER3-NODAGA. Presence of the negatively charged 68Ga-DOTAGA complex reduced the unspecific hepatic uptake, but did not improve overall biodistribution of the conjugate. [68Ga]Ga-(HE)3-ZHER3-DOTAGA and [68Ga]Ga-(HE)3-ZHER3-NODAGA had similar tumor-to-liver ratios, but [68Ga]Ga-(HE)3-ZHER3-NODAGA had the highest tumor uptake and tumor-to-blood ratio among the tested conjugates. In conclusion, [68Ga]Ga-(HE)3-ZHER3-NODAGA remains the favorable variant for PET imaging of HER3 expression.

Kinetics of 76Br-labeled anti-CEA antibodies in pigs; Aspects of dosimetry and PET imaging properties

1999 ◽  
Vol 26 (2) ◽  
pp. 249-258 ◽  
Author(s):  
Anna Lövqvist ◽  
Hans Lundqvist ◽  
Mark Lubberink ◽  
Vladimir Tolmachev ◽  
Jörgen Carlsson ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Imaging Properties ◽  
Kinetics Of

Anti-CEA Antibody Fragments Labeled with [18F]AlF for PET Imaging of CEA-Expressing Tumors

2014 ◽  
Vol 25 (2) ◽  
pp. 335-341 ◽  
Author(s):  
S. Lütje ◽  
G. M. Franssen ◽  
R. M. Sharkey ◽  
P. Laverman ◽  
E. A. Rossi ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Antibody Fragments

scholarly journals Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo

2014 ◽  
Vol 111 (3) ◽  
pp. 1108-1113 ◽  
Author(s):  
R. Tavare ◽  
M. N. McCracken ◽  
K. A. Zettlitz ◽  
S. M. Knowles ◽  
F. B. Salazar ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Pet Imaging ◽  
Antibody Fragments

scholarly journals Recombinant Anti-CD20 Antibody Fragments for Small-Animal PET Imaging of B-Cell Lymphomas

2009 ◽  
Vol 50 (9) ◽  
pp. 1500-1508 ◽  
Author(s):  
T. Olafsen ◽  
D. Betting ◽  
V. E. Kenanova ◽  
F. B. Salazar ◽  
P. Clarke ◽  
...  
Keyword(s):  
B Cell ◽  
Pet Imaging ◽  
Small Animal ◽  
Antibody Fragments ◽  
Small Animal Pet ◽  
B Cell Lymphomas ◽  
Animal Pet ◽  
Cd20 Antibody ◽  
Anti Cd20

scholarly journals Positron and γ-ray intensities in the decay of 45Ti

2015 ◽  
Vol 103 (6) ◽  
Author(s):  
Sebastian Kuhn ◽  
Ingo Spahn ◽  
Bernhard Scholten ◽  
Heinz H. Coenen
Keyword(s):  
Pet Imaging ◽  
Γ Ray ◽  
Positron Emitter ◽  
Imaging Properties

AbstractTo evaluate the PET-imaging properties of the promising positron emitter

scholarly journals Engineered Antibody Fragments with Infinite Affinity as Reporter Genes for PET Imaging

2008 ◽  
Vol 49 (11) ◽  
pp. 1828-1835 ◽  
Author(s):  
L. H. Wei ◽  
T. Olafsen ◽  
C. Radu ◽  
I. J. Hildebrandt ◽  
M. R. McCoy ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Reporter Genes ◽  
Antibody Fragments
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