A role for surfactant protein D in innate immunity of the human prostate

The Prostate ◽  
2005 ◽  
Vol 65 (3) ◽  
pp. 241-251 ◽  
Author(s):  
Rebecca E. Oberley ◽  
Kelli L. Goss ◽  
Laila Dahmoush ◽  
Kevin A. Ault ◽  
Erika C. Crouch ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Surfactant Protein ◽  
Human Prostate ◽  
Surfactant Protein D

scholarly journals Surfactant Protein D, a Marker of Lung Innate Immunity, Is Positively Associated With Insulin Sensitivity

Diabetes Care ◽  
2010 ◽  
Vol 33 (4) ◽  
pp. 847-853 ◽  
Author(s):  
J. M. Fernandez-Real ◽  
S. Valdes ◽  
M. Manco ◽  
B. Chico ◽  
P. Botas ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Insulin Sensitivity ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Lung Innate Immunity

scholarly journals Age-Related Expression of IFN-λ1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals

2021 ◽  
Vol 12 ◽  
Author(s):  
Charly Gilbert ◽  
Caroline Lefeuvre ◽  
Laurence Preisser ◽  
Adeline Pivert ◽  
Raffaella Soleti ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Expression Patterns ◽  
Age Groups ◽  
The Elderly ◽  
Surfactant Protein ◽  
Innate Immune ◽  
Surfactant Protein D ◽  
Type I ◽  
Mrna Levels ◽  
Age Related

SARS-CoV-2 coronavirus infection induces heterogeneous symptoms, ranging from asymptomatic to lethal forms. Severe forms usually occur in the elderly and/or individuals with comorbidities. Children generally remain asymptomatic to primary infection, suggesting that they may have an effective local innate immune response. IFN-I and -III have non-redundant protective roles against SARS-CoV-2, although sometimes damaging the host. The expression and role of anti-viral peptides during SARS-CoV-2 infection have thus far been little studied. We aimed to identify the innate immune molecules present at the SARS-CoV-2 entry point. We analyzed the mRNA levels of type I (IFN-α and -β) and type III (IFN-λ1-3) interferons and selected antiviral peptides (i.e., β-defensins 1-3, α-defensins [HNP1-3, HD5] pentraxin-3, surfactant protein D, the cathelicidin LL-37 and interleukin-26) in nasopharyngeal swabs from 226 individuals of various ages, either infected with SARS-CoV-2 (symptomatic or asymptomatic) or negative for the virus. We observed that infection induced selective upregulation of IFN-λ1 expression in pediatric subjects (≤15 years), whereas IFN-α, IFN-β, IFN-λ2/λ3, and β-defensin 1-3 expression was unaffected. Conversely, infection triggered upregulation of IFN-α, IFN-β, IFN-λ2/λ3, and β-defensin 1-3 mRNA expression in adults (15-65 years) and the elderly (≥ 65 years), but without modulation of IFN-λ1. The expression of these innate molecules was not associated with gender or symptoms. Expression of the interferon-stimulated genes IFITM1 and IFITM3 was upregulated in SARS-CoV-2-positive subjects and reached similar levels in the three age groups. Finally, age-related differences in nasopharyngeal innate immunity were also observed in SARS-CoV-2-negative subjects. This study shows that the expression patterns of IFN-I/-III and certain anti-viral molecules in the nasopharyngeal mucosa of SARS-CoV-2-infected subjects differ with age and suggests that susceptibility to SARS-CoV-2 may be related to intrinsic differences in the nature of mucosal anti-viral innate immunity.

scholarly journals Role of Surfactant Protein D in Experimental Otitis Media

2021 ◽  
pp. 1-14
Author(s):  
Osama Abdel-Razek ◽  
Tianyi Liu ◽  
Xinghua Chen ◽  
Qiushi Wang ◽  
Gautam Vanga ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Otitis Media ◽  
Critical Role ◽  
Surfactant Protein ◽  
Saline Control ◽  
Surfactant Protein D ◽  
Bacterial Colony ◽  
Sterile Saline ◽  
Mucosal Thickness

Surfactant protein D (SP-D) is a C-type collectin and plays an important role in innate immunity and homeostasis in the lung. This study studied SP-D role in the nontypeable <i>Haemophilus influenzae</i> (NTHi)-induced otitis media (OM) mouse model. Wild-type C57BL/6 (WT) and SP-D knockout (KO) mice were used in this study. Mice were injected in the middle ear (ME) with 5 μL of NTHi bacterial solution (3.5 × 10<sup>5</sup> CFU/ear) or with the same volume of sterile saline (control). Mice were sacrificed at 3 time points, days 1, 3, and 7, after treatment. We found SP-D expression in the Eustachian tube (ET) and ME mucosa of WT mice but not in SP-D KO mice. After infection, SP-D KO mice showed more intense inflammatory changes evidenced by the increased mucosal thickness and inflammatory cell infiltration in the ME and ET compared to WT mice (<i>p</i> &#x3c; 0.05). Increased bacterial colony-forming units and cytokine (IL-6 and IL-1β) levels in the ear washing fluid of infected SP-D KO mice were compared to infected WT mice. Molecular analysis revealed higher levels of NF-κB and NLRP3 activation in infected SP-D KO compared to WT mice (<i>p</i> &#x3c; 0.05). In vitro studies demonstrated that SP-D significantly induced NTHi bacterial aggregation and enhanced bacterial phagocytosis by macrophages (<i>p</i> &#x3c; 0.05)<i>.</i> Furthermore, human ME epithelial cells showed a dose-dependent increased expression of NLRP3 and SP-D proteins after LPS treatment. We conclude that SP-D plays a critical role in innate immunity and disease resolution through enhancing host defense and regulating inflammatory NF-κB and NLRP3 activation in experimental OM mice.

The role of surfactant protein D in fibrotic lung remodelling

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
J Viereck ◽  
L Knudsen ◽  
JP Schneider ◽  
M Ochs ◽  
T Thum
Keyword(s):  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Lung Remodelling
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