Calculating pKa values in the cAMP-dependent protein kinase: The effect of conformational change and ligand binding

Una Bjarnadottir; Jens Erik Nielsen

doi:10.1002/pro.530

Calculating pKa values in the cAMP-dependent protein kinase: The effect of conformational change and ligand binding

Protein Science ◽

10.1002/pro.530 ◽

2010 ◽

Vol 19 (12) ◽

pp. 2485-2497 ◽

Cited By ~ 4

Author(s):

Una Bjarnadottir ◽

Jens Erik Nielsen

Keyword(s):

Protein Kinase ◽

Ligand Binding ◽

Conformational Change ◽

Dependent Protein Kinase ◽

Pka Values ◽

Camp Dependent Protein Kinase ◽

Dependent Protein

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Ligand binding site interaction in adenosine cyclic 3',5'-monophosphate-dependent protein kinase catalytic subunit: circular dichroic evidence for intramolecular transmission of conformational change

Biochemistry ◽

10.1021/bi00300a026 ◽

1984 ◽

Vol 23 (5) ◽

pp. 968-973 ◽

Cited By ~ 19

Author(s):

Jennifer Reed ◽

Volker Kinzel

Keyword(s):

Protein Kinase ◽

Ligand Binding ◽

Binding Site ◽

Conformational Change ◽

Catalytic Subunit ◽

Ligand Binding Site ◽

Dependent Protein Kinase ◽

Dependent Protein ◽

Circular Dichroic

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MgATP-induced conformational change of the catalytic subunit of cAMP-dependent protein kinase

Biophysical Chemistry ◽

10.1016/j.bpc.2004.08.008 ◽

2005 ◽

Vol 113 (2) ◽

pp. 193-199 ◽

Cited By ~ 3

Author(s):

Shumei Yang ◽

Kestrel M. Rogers ◽

David A. Johnson

Keyword(s):

Protein Kinase ◽

Conformational Change ◽

Catalytic Subunit ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Dependent Protein

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Fluorescence energy transfer between cysteine 199 and cysteine 343: evidence for magnesium ATP-dependent conformational change in the catalytic subunit of cAMP-dependent protein kinase

Biochemistry ◽

10.1021/bi00434a068 ◽

1989 ◽

Vol 28 (8) ◽

pp. 3606-3613 ◽

Cited By ~ 7

Author(s):

Eric A. First ◽

David A. Johnson ◽

Susan S. Taylor

Keyword(s):

Energy Transfer ◽

Protein Kinase ◽

Conformational Change ◽

Catalytic Subunit ◽

Fluorescence Energy Transfer ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Dependent Protein ◽

Fluorescence Energy

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Phosphorylation by cAMP-Dependent Protein Kinase Causes a Conformational Change in the R Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

Biochemistry ◽

10.1021/bi00179a036 ◽

1994 ◽

Vol 33 (13) ◽

pp. 4072-4079 ◽

Cited By ~ 69

Author(s):

Ann M. Dulhanty ◽

John R. Riordan

Keyword(s):

Cystic Fibrosis ◽

Protein Kinase ◽

Conformational Change ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Dependent Protein ◽

Cystic Fibrosis Transmembrane ◽

R Domain

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Determinants of Ligand Binding to cAMP-Dependent Protein Kinase†

Biochemistry ◽

10.1021/bi982064g ◽

1999 ◽

Vol 38 (8) ◽

pp. 2358-2366 ◽

Cited By ~ 55

Author(s):

Philippe H. Hünenberger ◽

Volkhard Helms ◽

Narendra Narayana ◽

Susan S. Taylor ◽

J. Andrew McCammon

Keyword(s):

Protein Kinase ◽

Ligand Binding ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Dependent Protein

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Circular dichroic evidence for an ordered sequence of ligand/binding site interactions in the catalytic reaction of the cAMP-dependent protein kinase

Biochemistry ◽

10.1021/bi00333a024 ◽

1985 ◽

Vol 24 (12) ◽

pp. 2967-2973 ◽

Cited By ~ 39

Author(s):

Jennifer Reed ◽

Volker Kinzel ◽

Bruce E. Kemp ◽

Hueng Chin Cheng ◽

Donal A. Walsh

Keyword(s):

Protein Kinase ◽

Ligand Binding ◽

Binding Site ◽

Catalytic Reaction ◽

Ligand Binding Site ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Dependent Protein ◽

Circular Dichroic

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cAMP exerts proliferative and anti-proliferative effects in pituitary cells of different types by activating both cAMP-dependent protein kinase A and exchange proteins directly activated by cAMP

Endocrine Abstracts ◽

10.1530/endoabs.32.p827 ◽

2013 ◽

Author(s):

Eleonora Vitali ◽

Erika Peverelli ◽

Giovanna Mantovani ◽

Elena Giardino ◽

Andrea G. Lania ◽

...

Keyword(s):

Protein Kinase ◽

Protein Kinase A ◽

Pituitary Cells ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Different Types ◽

Dependent Protein ◽

Kinase A

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Faculty Opinions recommendation of Distal recognition sites in substrates are required for efficient phosphorylation by the cAMP-dependent protein kinase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1165205.628140 ◽

2009 ◽

Author(s):

Jonathan Chernoff

Keyword(s):

Protein Kinase ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Recognition Sites ◽

Dependent Protein

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Faculty Opinions recommendation of Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718291698.793492090 ◽

2014 ◽

Author(s):

Johannes Hell

Keyword(s):

Protein Kinase ◽

Differential Regulation ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Anchoring Proteins ◽

Dependent Protein ◽

Cav1.2 Channels

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Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus.

The EMBO Journal ◽

10.1002/j.1460-2075.1985.tb04006.x ◽

1985 ◽

Vol 4 (11) ◽

pp. 2801-2806 ◽

Cited By ~ 217

Author(s):

E.A. Nigg ◽

H. Hilz ◽

H.M. Eppenberger ◽

F. Dutly

Keyword(s):

Protein Kinase ◽

Golgi Complex ◽

Catalytic Subunit ◽

Type Ii ◽

Dependent Protein Kinase ◽

Camp Dependent Protein Kinase ◽

Dependent Protein

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