scholarly journals Disassembly of the ring‐type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation

2020 ◽  
Vol 29 (5) ◽  
pp. 1138-1147 ◽  
Author(s):  
Tomoki Himiyama ◽  
Tsutomu Nakamura
Keyword(s):  
Amino Acid ◽  
Amino Acid Mutation ◽  
Ring Type ◽  
Aeropyrum Pernix

scholarly journals Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

Science ◽  
2021 ◽  
Vol 371 (6531) ◽  
pp. 850-854 ◽  
Author(s):  
Tyler N. Starr ◽  
Allison J. Greaney ◽  
Amin Addetia ◽  
William W. Hannon ◽  
Manish C. Choudhary ◽  
...  
Keyword(s):  
Amino Acid ◽  
Infected Patient ◽  
Viral Escape ◽  
Single Amino Acid ◽  
Receptor Binding Domain ◽  
Amino Acid Mutation ◽  
The Individual ◽  
Viral Surveillance ◽  
Single Amino Acid Mutation

Antibodies are a potential therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the risk of the virus evolving to escape them remains unclear. Here we map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LY-CoV016. These complete maps uncover a single amino acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies, REGN10933 and REGN10987, targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2 and during in vitro viral escape selections. Finally, the maps reveal that mutations escaping the individual antibodies are already present in circulating SARS-CoV-2 strains. These complete escape maps enable interpretation of the consequences of mutations observed during viral surveillance.

Prevalence of Amino acid mutation in hepatitis C virus core region among Japanese volunteer blood donors

2011 ◽  
Vol 83 (11) ◽  
pp. 1924-1929 ◽  
Author(s):  
Yasumi Furui ◽  
Yuji Hoshi ◽  
Kazumoto Murata ◽  
Kiyoaki Ito ◽  
Kou Suzuki ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Amino Acid ◽  
Blood Donors ◽  
Core Region ◽  
Amino Acid Mutation ◽  
Virus Core ◽  
Japanese Volunteer
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