scholarly journals Hidden thermodynamic information in protein amino acid mutation tables

2017 ◽  
Vol 469 ◽  
pp. 676-680 ◽  
Author(s):  
J.C. Phillips
Keyword(s):  
Amino Acid ◽  
Amino Acid Mutation ◽  
Protein Amino Acid

scholarly journals Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

Science ◽  
2021 ◽  
Vol 371 (6531) ◽  
pp. 850-854 ◽  
Author(s):  
Tyler N. Starr ◽  
Allison J. Greaney ◽  
Amin Addetia ◽  
William W. Hannon ◽  
Manish C. Choudhary ◽  
...  
Keyword(s):  
Amino Acid ◽  
Infected Patient ◽  
Viral Escape ◽  
Single Amino Acid ◽  
Receptor Binding Domain ◽  
Amino Acid Mutation ◽  
The Individual ◽  
Viral Surveillance ◽  
Single Amino Acid Mutation

Antibodies are a potential therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the risk of the virus evolving to escape them remains unclear. Here we map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LY-CoV016. These complete maps uncover a single amino acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies, REGN10933 and REGN10987, targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2 and during in vitro viral escape selections. Finally, the maps reveal that mutations escaping the individual antibodies are already present in circulating SARS-CoV-2 strains. These complete escape maps enable interpretation of the consequences of mutations observed during viral surveillance.

Isolation from atelia herbert-smithii pittier (sophoreae, leguminosae) and x-ray structure of cis-1-amino-3-hydroxymethyl-cyclobutane-1-carboxylic acid, an achiral non-protein amino acid

Tetrahedron ◽  
1987 ◽  
Vol 43 (8) ◽  
pp. 1857-1861 ◽  
Author(s):  
Geoffrey N. Austin ◽  
Peter D. Baird ◽  
Hak-Fun Chow ◽  
L.E. Fellows ◽  
G.W.J. Fleet ◽  
...  
Keyword(s):  
Amino Acid ◽  
Carboxylic Acid ◽  
Protein Amino Acid ◽  
X Ray

scholarly journals Homocysteine Is a Protein Amino Acid in Humans

2002 ◽  
Vol 277 (34) ◽  
pp. 30425-30428 ◽  
Author(s):  
Hieronim Jakubowski
Keyword(s):  
Amino Acid ◽  
Protein Amino Acid

scholarly journals The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of l-Serine Causing Protein Misfolding and Aggregation

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e75376 ◽  
Author(s):  
Rachael Anne Dunlop ◽  
Paul Alan Cox ◽  
Sandra Anne Banack ◽  
Kenneth John Rodgers
Keyword(s):  
Amino Acid ◽  
Protein Misfolding ◽  
Protein Amino Acid ◽  
Human Proteins ◽  
Protein Misfolding And Aggregation

039 Comparison of the effects of reduced–crude protein, amino acid–supplemented diets on growth performance in swine

2016 ◽  
Vol 94 (suppl_2) ◽  
pp. 17-18
Author(s):  
C. E. Vonderohe ◽  
K. M. Mills ◽  
M. D. Asmus ◽  
E. R. Otto-Tice ◽  
C. V. Maxwell ◽  
...  
Keyword(s):  
Amino Acid ◽  
Growth Performance ◽  
Crude Protein ◽  
Protein Amino Acid ◽  
Reduced Crude Protein
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