scholarly journals Effect of circular permutation on the structure and function of type 1 blue copper center in azurin

2016 ◽  
Vol 26 (2) ◽  
pp. 218-226 ◽  
Author(s):  
Yang Yu ◽  
Igor D. Petrik ◽  
Kelly N. Chacón ◽  
Parisa Hosseinzadeh ◽  
Honghui Chen ◽  
...  
Keyword(s):  
Circular Permutation ◽  
Structure And Function ◽  
Blue Copper ◽  
Copper Center ◽  
And Function

scholarly journals Engineering the metal-binding loop at a type 1 copper center by circular permutation

RSC Advances ◽  
2017 ◽  
Vol 7 (88) ◽  
pp. 56093-56098
Author(s):  
Honghui Chen ◽  
Binbin Su ◽  
Tongtong Zhang ◽  
Aiping Huang ◽  
Haiping Liu ◽  
...  
Keyword(s):  
Metal Binding ◽  
Circular Permutation ◽  
Type 1 Copper ◽  
Copper Center ◽  
Binding Loop

Circular permutation of the cupredoxin azurin creates a break on the metal binding loop, highlighting the loop's flexibility.

scholarly journals Structure and function insights garnered from in silico modeling of the thrombospondin type-1 domain-containing 7A antigen

2018 ◽  
Vol 87 (2) ◽  
pp. 136-145 ◽  
Author(s):  
Shana V. Stoddard ◽  
Colin L. Welsh ◽  
Maggie M. Palopoli ◽  
Serena D. Stoddard ◽  
Mounika P. Aramandla ◽  
...  
Keyword(s):  
In Silico ◽  
Structure And Function ◽  
In Silico Modeling ◽  
And Function

scholarly journals Supplementation of Type 1 Diabetic Rats with Carrot Powder Lowers Blood Glucose without Improving Cardiac Structure and Function

2018 ◽  
Vol 23 (2) ◽  
pp. 115-121
Author(s):  
Xavier Lieben Louis ◽  
Pema Raj ◽  
Kathleen J. McClinton ◽  
Liping Yu ◽  
Miyoung Suh ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Diabetic Rats ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Cardiac Structure And Function ◽  
And Function

Physical Activity and Nerve Structure and Function in Patients With Longstanding Type 1 Diabetes

2021 ◽  
Vol 45 (7) ◽  
pp. S7
Author(s):  
Evan Lewis ◽  
Leif Erik Lovblom ◽  
Sebastien Lanctot ◽  
Daniel Scarr ◽  
Vera Bril ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 1 Diabetes ◽  
Structure And Function ◽  
Nerve Structure ◽  
And Function

scholarly journals Thirty two novel nsSNPs May effect on HEXA protein Leading to Tay-Sachs disease (TSD) Using a Computational Approach

2019 ◽  
Author(s):  
Tebyan A. Abdelhameed ◽  
Mohamed Mustafa Osman Fadul ◽  
Dina Nasereldin Abdelrahman Mohamed ◽  
Amal Mohamed Mudawi ◽  
Sayaf Kamal Khalifa Fadul Allah ◽  
...  
Keyword(s):  
Nucleotide Substitution ◽  
Neurodegenerative Disorder ◽  
Structure And Function ◽  
Single Nucleotide Substitution ◽  
Single Nucleotide ◽  
Bioinformatics Tools ◽  
Tay Sachs Disease ◽  
Hexosaminidase A ◽  
And Function

ABSTRACTBackgroundGenetic polymorphisms in the HEXA gene are associated with a neurodegenerative disorder called Tay-Sachs disease (TSD) (GM2 gangliosidosis type 1). This study aimed to predict the possible pathogenic SNPs of this gene and their impact on the protein using different bioinformatics tools.MethodsSNPs retrieved from the NCBI database were analyzed using several bioinformatics tools. The different algorithms collectively predicted the effect of single nucleotide substitution on both structure and function of the hexosaminidase A protein.ResultsFifty nine mutations were found to be highly damaging to the structure and function of the HEXA gene protein.ConclusionAccording to this study, thirty two novel nsSNP in HEXA are predicted to have possible role in Tay-Saches Disease using different bioinformatics tools. Our findings could help in genetic study and diagnosis of Tay-Saches Disease.

scholarly journals Structure and function analyses of the purified GPCR human vomeronasal type 1 receptor 1

2011 ◽  
Vol 1 (1) ◽  
Author(s):  
Karolina Corin ◽  
Philipp Baaske ◽  
Sandra Geissler ◽  
Christoph J. Wienken ◽  
Stefan Duhr ◽  
...  
Keyword(s):  
Structure And Function ◽  
And Function
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