Treadmill Training or Progressive Strength Training to Improve Walking in People with Multiple Sclerosis? A Randomized Parallel Group Trial

2015 ◽  
Vol 21 (4) ◽  
pp. 228-236 ◽  
Author(s):  
Siri Merete Braendvik ◽  
Teija Koret ◽  
Jorunn L. Helbostad ◽  
Håvard Lorås ◽  
Geir Bråthen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Strength Training ◽  
Treadmill Training ◽  
Parallel Group ◽  
Progressive Strength Training ◽  
Parallel Group Trial ◽  
Group Trial

A randomized trial of memantine as treatment for spasticity in multiple sclerosis

2009 ◽  
Vol 16 (2) ◽  
pp. 248-251 ◽  
Author(s):  
Lahar R Mehta ◽  
Michael P McDermott ◽  
Andrew D Goodman ◽  
Steven R Schwid
Keyword(s):  
Multiple Sclerosis ◽  
Primary Outcome ◽  
Primary Outcome Measure ◽  
Double Blind ◽  
Lower Extremity Muscle ◽  
Memantine Treatment ◽  
Parallel Group ◽  
To Receive ◽  
Parallel Group Trial ◽  
Group Trial

We report the results of a single center randomized, double-blind, placebo-controlled, parallel group trial of memantine in adults with multiple sclerosis and spasticity conducted over 12 weeks. Eligible MS patients had to have an Ashworth spasticity rating of 2 or higher in at least one lower extremity muscle group. Subjects were randomized to receive either placebo or memantine 10 mg twice a day. The primary outcome measure for efficacy was the change in Ashworth Spasticity Scale Score. Although well tolerated, memantine treatment did not demonstrate efficacy in treatment of spasticity in this 12-week small exploratory study.

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