Comprehension of confidence intervals in audio-visual patient information materials for people with multiple sclerosis (COCO-MS): A web-based randomised controlled, parallel group trial

2020 ◽  
Author(s):  
Anne C. Rahn ◽  
Karin Riemann-Lorenz ◽  
Anna Alegiani ◽  
Gesa E.A. Pust ◽  
Adrianus van de Roemer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Confidence Intervals ◽  
Patient Information ◽  
Web Based ◽  
Parallel Group ◽  
Information Materials ◽  
Randomised Controlled ◽  
Parallel Group Trial ◽  
Group Trial

scholarly journals Choice of Moisturiser for Eczema Treatment (COMET): feasibility study of a randomised controlled parallel group trial in children recruited from primary care

BMJ Open ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. e012021 ◽  
Author(s):  
Matthew J Ridd ◽  
Kirsty Garfield ◽  
Daisy M Gaunt ◽  
Sandra Hollinghurst ◽  
Niamh M Redmond ◽  
...  
Keyword(s):  
Primary Care ◽  
Feasibility Study ◽  
Parallel Group ◽  
Randomised Controlled ◽  
Parallel Group Trial ◽  
Group Trial

A randomized trial of memantine as treatment for spasticity in multiple sclerosis

2009 ◽  
Vol 16 (2) ◽  
pp. 248-251 ◽  
Author(s):  
Lahar R Mehta ◽  
Michael P McDermott ◽  
Andrew D Goodman ◽  
Steven R Schwid
Keyword(s):  
Multiple Sclerosis ◽  
Primary Outcome ◽  
Primary Outcome Measure ◽  
Double Blind ◽  
Lower Extremity Muscle ◽  
Memantine Treatment ◽  
Parallel Group ◽  
To Receive ◽  
Parallel Group Trial ◽  
Group Trial

We report the results of a single center randomized, double-blind, placebo-controlled, parallel group trial of memantine in adults with multiple sclerosis and spasticity conducted over 12 weeks. Eligible MS patients had to have an Ashworth spasticity rating of 2 or higher in at least one lower extremity muscle group. Subjects were randomized to receive either placebo or memantine 10 mg twice a day. The primary outcome measure for efficacy was the change in Ashworth Spasticity Scale Score. Although well tolerated, memantine treatment did not demonstrate efficacy in treatment of spasticity in this 12-week small exploratory study.

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