The contribution of proteomic studies in humans, animal models, and after antidepressant treatments to investigate the molecular neurobiology of major depression

2015 ◽  
Vol 9 (9-10) ◽  
pp. 889-898 ◽  
Author(s):  
Lucia Carboni
Keyword(s):  
Major Depression ◽  
Animal Models ◽  
Antidepressant Treatments

S.27.03 Decreased VGLUT1 levels and long-term chronic mild stress: animal models addressing specific aspects of major depression

2009 ◽  
Vol 19 ◽  
pp. S214-S215
Author(s):  
R.M. Tordera ◽  
A.L. Garcia-Garcia ◽  
N. Elizalde ◽  
E. Vénzala ◽  
M.J. Ramirez ◽  
...  
Keyword(s):  
Major Depression ◽  
Animal Models ◽  
Chronic Mild Stress ◽  
Mild Stress

scholarly journals Animal models of maternal depression for monitoring neurodevelopmental changes occurring in dams and offspring

2017 ◽  
Vol 10 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Eszter Bogi ◽  
Kristína Belovicova ◽  
Kristína Csatlosova ◽  
Michal Dubovicky
Keyword(s):  
Animal Models ◽  
Maternal Depression ◽  
Life Stress ◽  
Depressive Disorders ◽  
Early Life Stress ◽  
The Past ◽  
Antidepressant Treatments ◽  
Animal Model Of Depression ◽  
Relevant Animal Model ◽  
Life Threatening

AbstractDepression is one of the most prevalent and life-threatening forms of mental illness affecting about 20% of the population. Depressive disorder as a biochemical phenomenon, was first recognized in the mid-20th century of research, however the etiology of this disease is still not well understood. Although the need to investigate depressive disorders has emerged from the needs of clinical practice, there are many preclinical studies, which brought new insights into this field of research. During experimental work it was crucial to develop appropriate animal models, where the neurohumoral mechanism was similar to humans. In the past decades, several animal models of maternal depression have been developed. We describe the three most popular rodent models of maternal depression which are based on 1. stress prior to gestation, 2. prenatal stress and 3. early life stress. The above-mentioned animal models appear to fulfill many criteria for a relevant animal model of depression; they alter the regulation of the HPA, induce signs of depression-like behavior and several antidepressant treatments can reverse the state induced by maternal stress. Although, they are not able to model all aspects of maternal depression, they are useful models for monitoring neurodevelopmental changes occurring in dams and offspring.

Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments

2001 ◽  
Vol 64 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Mustafa Bilici ◽  
Hasan Efe ◽  
M.Arif Köroğlu ◽  
Hüseyin Avni Uydu ◽  
M. Bekaroğlu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Major Depression ◽  
Enzyme Activities ◽  
Antioxidative Enzyme ◽  
Antidepressant Treatments ◽  
Antioxidative Enzyme Activities

Diagnosis of Depression in Alcohol Dependence: Changes in Prevalence with Drinking Status

1995 ◽  
Vol 166 (2) ◽  
pp. 199-204 ◽  
Author(s):  
Kate M. Davidson
Keyword(s):  
Major Depression ◽  
Alcohol Dependence ◽  
Alcohol Intoxication ◽  
Demographic Variables ◽  
Antidepressant Treatments ◽  
Drinking Status ◽  
The Relationship ◽  
Alcohol Related Problems ◽  
Abstinence From Alcohol ◽  
Alcohol Dependent

BackgroundDepression and alcohol dependence are frequently found to co-exist but the relationship between these disorders requires further elucidation. This study tested several hypotheses related to the relevance of whether the diagnosis of depression was made before admission or after detoxification in the current episode for those with alcohol dependence.MethodThe Schedule for Affective Disorders and Schizophrenia (SADS) was administered to obtain Research Diagnostic Criteria (RDC) on 82 randomly selected alcohol dependent in-patients. Alcohol-related (Severity of Alcohol Dependence Questionnaire (SADQ), alcohol consumption and alcohol-related problems), socio-demographic variables and treatment for depression were assessed.ResultsFor the episode of drinking which led to admission, a diagnosis of major depression was found in the majority of patients (67%). Once detoxification from alcohol took place, only the minority (13%) met criteria for major depression.ConclusionsIt is suggested that depression is largely associated with the episode of drinking which led to admission in patients who are dependent on alcohol and may be due to the effect of chronic alcohol intoxication. Socio-demographic and alcohol-related characteristics appear to bear little relation to the presence of depression. Clinicians exercise appropriate judgement in not prescribing antidepressant treatments to patients whose depression may remit with abstinence from alcohol.

scholarly journals Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression

2012 ◽  
Vol 2 (4) ◽  
pp. e101-e101 ◽  
Author(s):  
K Pajer ◽  
B M Andrus ◽  
W Gardner ◽  
A Lourie ◽  
B Strange ◽  
...  
Keyword(s):  
Major Depression ◽  
Animal Models ◽  
Early Onset

scholarly journals Animal models of major depression: drawbacks and challenges

2019 ◽  
Vol 126 (11) ◽  
pp. 1383-1408 ◽  
Author(s):  
Barbara Planchez ◽  
Alexandre Surget ◽  
Catherine Belzung
Keyword(s):  
Major Depression ◽  
Animal Models ◽  
Poor Response ◽  
Treatment Resistant Depression ◽  
Recurrent Depression ◽  
Treatment Resistant ◽  
Neuronal Populations ◽  
Future Challenges ◽  
Resistant Depression ◽  
Depression Subtypes

Abstract Major depression is a leading contributor to the global burden of disease. This situation is mainly related to the chronicity and/or recurrence of the disorder, and to poor response to antidepressant therapy. Progress in this area requires valid animal models. Current models are based either on manipulating the environment to which rodents are exposed (during the developmental period or adulthood) or biological underpinnings (i.e. gene deletion or overexpression of candidate genes, targeted lesions of brain areas, optogenetic control of specific neuronal populations, etc.). These manipulations can alter specific behavioural and biological outcomes that can be related to different symptomatic and pathophysiological dimensions of major depression. However, animal models of major depression display substantial shortcomings that contribute to the lack of innovative pharmacological approaches in recent decades and which hamper our capabilities to investigate treatment-resistant depression. Here, we discuss the validity of these models, review putative models of treatment-resistant depression, major depression subtypes and recurrent depression. Furthermore, we identify future challenges regarding new paradigms such as those proposing dimensional rather than categorical approaches to depression.

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