Bronchodilator response to albuterol nebulized with hypertonic saline in asthmatic children

2021 ◽  
Author(s):  
Alejandro Teper ◽  
Carlos Kofman ◽  
Jessica Alchundia Moreira ◽  
Teresa Köhler ◽  
Facundo García Bournissen
Keyword(s):  
Hypertonic Saline ◽  
Bronchodilator Response ◽  
Asthmatic Children

scholarly journals Comparison of bronchodilator response in asthmatic children using spirometry and oscillometry

2019 ◽  
Vol 143 (2) ◽  
pp. AB11
Author(s):  
Toshiko Itazawa ◽  
Yoshie Okabe ◽  
Takuya Wada ◽  
Shokei Murakami ◽  
Yasunori Ito ◽  
...  
Keyword(s):  
Bronchodilator Response ◽  
Asthmatic Children

scholarly journals Oscillometric and Spirometric Bronchodilator Response in Preschool Children with and without Asthma

2012 ◽  
Vol 19 (4) ◽  
pp. 273-277 ◽  
Author(s):  
Youn Ho Shin ◽  
Sun Jung Jang ◽  
Jung Won Yoon ◽  
Hye Mi Jee ◽  
Sun Hee Choi ◽  
...  
Keyword(s):  
Preschool Children ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Bronchodilator Response ◽  
Asthmatic Children ◽  
Before And After ◽  
Forced Expiratory Flow ◽  
Quality Control Criteria ◽  
Control Criteria

BACKGROUND: Bronchodilator responses (BDR) are routinely used in the diagnosis and management of asthma; however, their acceptability and repeatability have not been evaluated using quality control criteria for preschool children.OBJECTIVES: To compare conventional spirometry with an impulse oscillometry system (IOS) in healthy and asthmatic preschool children.METHODS: Data from 30 asthmatic children and 29 controls (two to six years of age) who underwent IOS and spirometry before and after salbutamol administration were analyzed.RESULTS: Stable asthmatic subjects significantly differed versus controls in their spirometry-assessed BDR (forced expiratory volume in 1 s [FEV1], forced vital capacity and forced expiratory flow at 25% to 75% of forced vital capacity) as well as their IOS-assessed BDR (respiratory resistance at 5 Hz [Rrs5], respiratory reactance at 5 Hz and area under the reactance curve). However, comparisons based on the area under the ROC curve for ΔFEV1% initial versus ΔRrs5% initial were 0.82 (95% CI 0.71 to 0.93) and 0.75 (95% CI 0.62 to 0.87), respectively. Moreover, the sensitivity and specificity for ΔFEV1≥9% were 0.53 and 0.93, respectively. Importantly, sensitivity increased to 0.63 when either ΔFEV1≥9% or ΔRrs5≥29% was considered as an additional criterion for the diagnosis of asthma.CONCLUSION: The accuracy of asthma diagnosis in preschool children may be increased by combining spirometry with IOS when measuring BDR.

scholarly journals ADRB2 gene polymorphisms and salbutamol responsiveness in Serbian children with asthma

2018 ◽  
Vol 21 (1) ◽  
pp. 33-38 ◽  
Author(s):  
N Jovicic ◽  
T Babic ◽  
S Dragicevic ◽  
B Nestorovic ◽  
A Nikolic
Keyword(s):  
Asthma Severity ◽  
Cross Sectional Study ◽  
Asthma Therapy ◽  
Cross Sectional ◽  
Bronchodilator Response ◽  
Asthmatic Children ◽  
Children With Asthma ◽  
Β2 Adrenergic Receptor ◽  
The University ◽  
Inhaled Salbutamol

Abstract Inhaled β2 adrenergic receptor (β2-AR) agonists are the mainstay of asthma therapy. The β2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children’s Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A>G (Arg16Gly, rs1042713) and +79C>G (Gln27Glu, rs 1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +46G was found to be associated with a better response to inhaled salbutamol (p <0.05) and with mild form of asthma (p <0.05). Polymorphism ADRB2 +46A>G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C>G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.

scholarly journals Randomized trial of physiotherapy and hypertonic saline techniques for sputum induction in asthmatic children and adolescents

Clinics ◽  
2020 ◽  
Vol 75 ◽  
Author(s):  
Egberto Luiz Felicio-Júnior ◽  
Viviani Barnabé ◽  
Francine Maria de Almeida ◽  
Monise Dematte Avona ◽  
Isabella Santos de Genaro ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Children And Adolescents ◽  
Hypertonic Saline ◽  
Sputum Induction ◽  
Asthmatic Children

Determining the Time to Maximal Bronchodilator Response in Asthmatic Children

2009 ◽  
Vol 46 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Vaska Stavreska ◽  
Maureen Verheggen ◽  
Jan Oostryck ◽  
Stephen M. Stick ◽  
Graham L. Hall
Keyword(s):  
Bronchodilator Response ◽  
Asthmatic Children

Bronchodilator Response in Asthmatic Children is Significantly Reduced When Measured Immediately After Methacholine Challenge

2002 ◽  
Vol 39 (8) ◽  
pp. 737-741 ◽  
Author(s):  
Arvid W. A. Kamps ◽  
Paul L. P. Brand ◽  
Karin Vermeer ◽  
Ruurd Jan Roorda
Keyword(s):  
Methacholine Challenge ◽  
Bronchodilator Response ◽  
Asthmatic Children
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