The bronchodilator response as a predictor of inhaled corticosteroid responsiveness in asthmatic children with normal baseline spirometry

2014 ◽  
Vol 49 (12) ◽  
pp. 1162-1169 ◽  
Author(s):  
Stanley P. Galant ◽  
Tricia Morphew ◽  
Olga Guijon ◽  
Linh Pham
Keyword(s):  
Inhaled Corticosteroid ◽  
Bronchodilator Response ◽  
Asthmatic Children

Inhaled corticosteroid treatment and growth of asthmatic children seen at outpatient clinics

2006 ◽  
Vol 82 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Elisete E. Arend ◽  
Gilberto B. Fischer ◽  
Márcio Debiasi ◽  
Helena Schmid
Keyword(s):  
Corticosteroid Treatment ◽  
Outpatient Clinics ◽  
Inhaled Corticosteroid ◽  
Asthmatic Children

Lung Growth and Linear Growth in Pre-pubertal Asthmatic Children Under Inhaled Corticosteroid Therapy (ICS)

2006 ◽  
Vol 117 (2) ◽  
pp. S96
Author(s):  
M. Malucelli ◽  
F. Tigrinho ◽  
L. Kovalhuk ◽  
C.A. Riedi ◽  
M.S. Cramer ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Linear Growth ◽  
Inhaled Corticosteroid ◽  
Lung Growth ◽  
Asthmatic Children

scholarly journals Comparison of bronchodilator response in asthmatic children using spirometry and oscillometry

2019 ◽  
Vol 143 (2) ◽  
pp. AB11
Author(s):  
Toshiko Itazawa ◽  
Yoshie Okabe ◽  
Takuya Wada ◽  
Shokei Murakami ◽  
Yasunori Ito ◽  
...  
Keyword(s):  
Bronchodilator Response ◽  
Asthmatic Children

scholarly journals Oscillometric and Spirometric Bronchodilator Response in Preschool Children with and without Asthma

2012 ◽  
Vol 19 (4) ◽  
pp. 273-277 ◽  
Author(s):  
Youn Ho Shin ◽  
Sun Jung Jang ◽  
Jung Won Yoon ◽  
Hye Mi Jee ◽  
Sun Hee Choi ◽  
...  
Keyword(s):  
Preschool Children ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Bronchodilator Response ◽  
Asthmatic Children ◽  
Before And After ◽  
Forced Expiratory Flow ◽  
Quality Control Criteria ◽  
Control Criteria

BACKGROUND: Bronchodilator responses (BDR) are routinely used in the diagnosis and management of asthma; however, their acceptability and repeatability have not been evaluated using quality control criteria for preschool children.OBJECTIVES: To compare conventional spirometry with an impulse oscillometry system (IOS) in healthy and asthmatic preschool children.METHODS: Data from 30 asthmatic children and 29 controls (two to six years of age) who underwent IOS and spirometry before and after salbutamol administration were analyzed.RESULTS: Stable asthmatic subjects significantly differed versus controls in their spirometry-assessed BDR (forced expiratory volume in 1 s [FEV1], forced vital capacity and forced expiratory flow at 25% to 75% of forced vital capacity) as well as their IOS-assessed BDR (respiratory resistance at 5 Hz [Rrs5], respiratory reactance at 5 Hz and area under the reactance curve). However, comparisons based on the area under the ROC curve for ΔFEV1% initial versus ΔRrs5% initial were 0.82 (95% CI 0.71 to 0.93) and 0.75 (95% CI 0.62 to 0.87), respectively. Moreover, the sensitivity and specificity for ΔFEV1≥9% were 0.53 and 0.93, respectively. Importantly, sensitivity increased to 0.63 when either ΔFEV1≥9% or ΔRrs5≥29% was considered as an additional criterion for the diagnosis of asthma.CONCLUSION: The accuracy of asthma diagnosis in preschool children may be increased by combining spirometry with IOS when measuring BDR.

scholarly journals Variability of bronchodilator response and effects of inhaled corticosteroid treatment in obstructive airways disease. Dutch CNSLD Study Group.

Thorax ◽  
1993 ◽  
Vol 48 (7) ◽  
pp. 722-729 ◽  
Author(s):  
H A Kerstjens ◽  
P L Brand ◽  
P H Quanjer ◽  
B A van der Bruggen-Bogaarts ◽  
G H Koeter ◽  
...  
Keyword(s):  
Corticosteroid Treatment ◽  
Study Group ◽  
Inhaled Corticosteroid ◽  
Bronchodilator Response ◽  
Obstructive Airways Disease

scholarly journals Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children

2020 ◽  
Author(s):  
Juan Huang ◽  
Xiaolei Hu ◽  
Xiangrong Zheng ◽  
Jian Kuang ◽  
Chentao Liu ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Childhood Asthma ◽  
Early Onset ◽  
Pulmonary Function Tests ◽  
Nucleotide Polymorphisms ◽  
Inhaled Corticosteroid ◽  
Chinese Han ◽  
Asthmatic Children ◽  
Asthma Risk ◽  
Increased Risk

Abstract Background: Asthma is a common chronic lung disease in children. We aimed to determine the associations between stress-induced phosphoprotein 1 (STIP1) and glucocorticoid-induced transcript 1 (GLCCI1) polymorphisms and susceptibility of childhood asthma and inhaled corticosteroid (ICS) response in children. Methods: A total of 263 Chinese Han asthmatic children were recruited from the Xiangya Hospital, Central South University. Pulmonary function tests were performed before the treatment and 3 months after the treatment. 150 non-asthmatic children were recruited. Each participant's DNA was extracted from the peripheral blood and Method of MassARRAY was used to genotype the single-nucleotide polymorphisms (SNPs). Results: STIP1 rs2236647 wild-type homozygote (CC) was associated with increased asthma risk of children (OR=1.858，95% CI：1.205-2.864), but not associated with the onset age of asthma and ICS response. GLCCI1 rs37969, rs37972 and rs37973 polymorphisms were not associated with the risk of childhood asthma. However, rs37969 mutant genotypes (TT/GT) were significantly associated with increased risk of early onset asthma (OR=2.254, 95% CI: 1.068-4.757) and less improvement in PD20 (p = 0.028). We also found significant associations between rs37969, rs37972 and rs37973 mutant genotypes and less improvement in maximal midexpiratory flow (MMEF) after ICS treatment for 3 months (p=0.036, p=0.010 and p=0.003, respectively). Conclusions: STIP1 rs2236647 was associated with asthma risk of children. GLCCI1 rs37969 mutant genotypes were associated with increased asthma risk of early onset and less improvement in airway hyper-responsiveness. GLCCI1 rs37969, rs37972 and rs37973 polymorphisms might be associated with pulmonary function in childhood asthma patients after ICS treatment.

Sign in / Sign up

Export Citation Format

Share Document