Protective effect of vitamin D against hyperoxia-induced lung injury in newborn rats

2016 ◽  
Vol 52 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Mehmet Kose ◽  
Osman Bastug ◽  
Mehmet Fatih Sonmez ◽  
Sedat Per ◽  
Ahmet Ozdemir ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lung Injury ◽  
Protective Effect ◽  
Newborn Rats

scholarly journals Protective Effect of Omega 3 and Vitamin D in Preventing Lung-tissue Damage of Newborn Rats Exposed to Cigarette Smoke during Intrauterine Period

2019 ◽  
Vol 37 (1) ◽  
pp. 87-92
Author(s):  
Zahide Küçük ◽  
Burcu Timur ◽  
Hayri Gözlükgiller ◽  
Hakan Timur ◽  
Kudret Erkenekli ◽  
...  
Keyword(s):  
Vitamin D ◽  
Protective Effect ◽  
Cigarette Smoke ◽  
Lung Tissue ◽  
Tissue Damage ◽  
Omega 3 ◽  
Newborn Rats ◽  
Lung Tissue Damage

Vitamin D Deficiency and Acute Lung Injury

2013 ◽  
Vol 12 (4) ◽  
pp. 253-261 ◽  
Author(s):  
Dhruv Parekh ◽  
David Thickett ◽  
Alice Turner
Keyword(s):  
Vitamin D ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Vitamin D Deficiency

scholarly journals In vitro and in vivo assessment of the protective effect of sufentanil in acute lung injury

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098635
Author(s):  
Qi Gao ◽  
Ningqing Chang ◽  
Donglian Liu
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protective Effect ◽  
High Mobility ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Inflammatory Factors ◽  
Luciferase Reporter ◽  
Hmgb1 Protein

Objectives To investigate the mechanisms underlying the protective effect of sufentanil against acute lung injury (ALI). Material and Methods Rats were administered lipopolysaccharide (LPS) by endotracheal instillation to establish a model of ALI. LPS was used to stimulate BEAS-2B cells. The targets and promoter activities of IκB were assessed using a luciferase reporter assay. Apoptosis of BEAS-2B cells was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling. Results Sufentanil treatment markedly reduced pathological changes in lung tissue, pulmonary edema and secretion of inflammatory factors associated with ALI in vivo and in vitro. In addition, sufentanil suppressed apoptosis induced by LPS and activated NF-κB both in vivo and in vitro. Furthermore, upregulation of high mobility group box protein 1 (HMGB1) protein levels and downregulation of miR-129-5p levels were observed in vivo and in vitro following sufentanil treatment. miR-129-5p targeted the 3ʹ untranslated region and its inhibition decreased promoter activities of IκB-α. miR-129-5p inhibition significantly weakened the protective effect of sufentanil on LPS-treated BEAS-2B cells. Conclusion Sufentanil regulated the miR-129-5p/HMGB1 axis to enhance IκB-α expression, suggesting that sufentanil represents a candidate drug for ALI protection and providing avenues for clinical treatment.

scholarly journals Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO): study protocol for a randomised placebo controlled trial

Trials ◽  
2013 ◽  
Vol 14 (1) ◽  
pp. 100 ◽  
Author(s):  
Dhruv Parekh ◽  
Rachel C A Dancer ◽  
Sian Lax ◽  
Mark S Cooper ◽  
Adrian R Martineau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Study Protocol ◽  
Controlled Trial

scholarly journals Protective Effect of Polydatin Against Burn-Induced Lung Injury in Rats

2014 ◽  
Vol 59 (9) ◽  
pp. 1412-1421 ◽  
Author(s):  
T. Li ◽  
S. Cai ◽  
Z. Zeng ◽  
J. Zhang ◽  
Y. Gao ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effect

Protective effect of ginsenoside Rg3 on lung injury in diabetic rats

2018 ◽  
Vol 120 (3) ◽  
pp. 3323-3330 ◽  
Author(s):  
Heyuan Wang ◽  
Wei Wu ◽  
Guixia Wang ◽  
Wenzhou Xu ◽  
Fuqiang Zhang ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effect ◽  
Diabetic Rats ◽  
Ginsenoside Rg3
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