Mid-childhood lung function in a cohort of children with “new bronchopulmonary dysplasia”

2016 ◽  
Vol 51 (10) ◽  
pp. 1057-1064 ◽  
Author(s):  
Manuela Fortuna ◽  
Silvia Carraro ◽  
Eva Temporin ◽  
Mariangela Berardi ◽  
Stefania Zanconato ◽  
...  
Keyword(s):  
Lung Function ◽  
Bronchopulmonary Dysplasia

scholarly journals Prediction of lung function and lung density of young adults who had bronchopulmonary dysplasia

2020 ◽  
Vol 6 (4) ◽  
pp. 00157-2020
Author(s):  
Helger Y. Santema ◽  
Jan Stolk ◽  
Mady Los ◽  
Berend C. Stoel ◽  
Roula Tsonaka ◽  
...  
Keyword(s):  
Young Adults ◽  
Lung Function ◽  
Bronchopulmonary Dysplasia ◽  
Adult Survivors ◽  
Lung Growth ◽  
Growth Duration ◽  
Lung Density ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Adult Lung

COPD risk is jointly determined by fetal lung development, lung growth rate and lung growth duration leading to the maximally attained level of lung function in early adulthood. Bronchopulmonary dysplasia (BPD) is considered a developmental arrest of alveolarisation. Long-term outcome studies of adult survivors born before the introduction of surfactant therapy (“old BPD”) showed impaired lung function. We aimed to predict adult lung function and lung density in a cohort of premature infants born in the surfactant era, representing “new BPD”.We studied a cohort of young adults born between 1987 and 1998, with (n=36) and without (n=28) BPD, treated in a single centre. Their perinatal characteristics and pulmonary function in infancy were studied by regression analysis for correlation with adult lung function and tissue lung density, all expressed by z-scores, at a mean age of 19.7±1.1 and 21±2.2 years, respectively.Although BPD adults had on average lower forced expiratory volume in 1 s (zFEV1)/forced vital capacity (FVC) and zFEV1 than those without, 55% of the BPD group had zFEV1/FVC values above the lower limit of normal (LLN). Moreover, above LLN values of diffusing capacity of the lung for carbon monoxide (zDLCO) was present in 89% of BPD adults and lung density in 71%. Only higher oxygen supply (FIO2) at 36 weeks post-conception of BPD subjects had a trend with lower zFEV1 (B=−6.4; p=0.053) and lower zDLCO (B=−4.1; p=0.023) at adulthood.No statistically significant predictors of new BPD were identified.

Functional respiratory imaging provides novel insights into the long-term respiratory sequelae of bronchopulmonary dysplasia

2020 ◽  
pp. 2002110
Author(s):  
Kristien Vanhaverbeke ◽  
Monique Slaats ◽  
Mohammed Al-Nejar ◽  
Niek Everaars ◽  
Annemiek Snoeckx ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Lung Function ◽  
Bronchopulmonary Dysplasia ◽  
Functional Assessment ◽  
Airway Resistance ◽  
Ct Images ◽  
Air Trapping ◽  
Distal Airway ◽  
Conventional Ct

RationaleBronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Lung function and imaging are classically used to assess BPD. Functional Respiratory Imaging (FRI) combines a structural and functional assessment of the airways and their vasculature. We aimed to assess BPD with FRI and to correlate these findings with the clinical presentation.MethodsWe included 37 adolescents with a history of preterm birth (22 BPD cases and 15 preterm controls). The study protocol included a detailed history, lung function testing and CT (at TLC and FRC) with FRI. CT images were also assessed using the Aukland scoring system.ResultsBPD patients had lower FEV1/FVC (p=0.02) and impaired diffusion capacity (p=0.02).Aukland CT scores were not different between the two groups. FRI analysis showed higher lobar volumes in BPD patients at FRC (p<0.01) but not at TLC. Airway resistance was significantly higher in the BPD group, especially in the distal airways. Additionally, FRI showed more air trapping in BPD patients, in contrast to findings on conventional CT images.ConclusionThis study is the first to use FRI in research for BPD. FRI analysis showed higher lobar volumes in BPD patients, indicating air trapping and reduced inspiratory capacity. In contrast to Aukland CT scores, FRI showed more air trapping in the BPD group, suggesting that FRI might be a more sensitive detection method. Importantly, we also showed increased distal airway resistance in BPD patients. By combining structural and functional assessment, FRI may help to better understand the long-term sequelae of BPD.

Respiratory Health and Lung Function in 8-Year-Old Children of Very Low Birth Weight: A Cohort Study

PEDIATRICS ◽  
1992 ◽  
Vol 89 (6) ◽  
pp. 1151-1158
Author(s):  
William H. Kitchen ◽  
Anthony Olinsky ◽  
Lex W. Doyle ◽  
Geoffrey W. Ford ◽  
Laurence J. Murton ◽  
...  
Keyword(s):  
Birth Weight ◽  
Lung Function ◽  
Low Birth Weight ◽  
Bronchopulmonary Dysplasia ◽  
Very Low Birth Weight ◽  
Respiratory Health ◽  
Hospital Readmissions ◽  
Flow Rates ◽  
Lower Birth Weight ◽  
Univariate Analyses

In comparison with a cohort of normal birth weight children, those of very low birth weight (&lt;1501 g birth weight) had more wheezing illnesses and hospital readmissions for respiratory problems in the first 2 years of life; from 2 years to 8 years of age respiratory health was unrelated to birth weight. Lung function measurements at 8 years of age in very low birth weight children were similar to expected values; few children had severely abnormal lung function. On univariate analyses, forced vital capacity (FVC) and forced expired volume in 1 second (FEV1), but not flow rates, were lower in children who had survived bronchopulmonary dysplasia. However, the univariate analyses were misleading, because bronchopulmonary dysplasia occurred more frequently with lower birth weight, and lower birth weight in turn was strongly related to reduced FVC and FEV1. After adjusting for birth weight and other potential confounding variables, FVC and FEV1 were unrelated to bronchopulmonary dysplasia, and to neonatal ventilation. Flow rates were largely uninfluenced by perinatal events, but were reduced in children with asthma or recurrent bronchitis at 8 years of age. Passive smoking was unrelated to lung function at 8 years of age. However, the effects of passive or active smoking, or perinatal events, on respiratory function or health beyond 8 years of age in very low birth weight survivors remain to be determined.

scholarly journals Respiratory morbidity, lung function and fitness assessment after bronchopulmonary dysplasia

2015 ◽  
Vol 35 (12) ◽  
pp. 1037-1042 ◽  
Author(s):  
M Praprotnik ◽  
I Stucin Gantar ◽  
M Lučovnik ◽  
T Avčin ◽  
U Krivec
Keyword(s):  
Lung Function ◽  
Bronchopulmonary Dysplasia ◽  
Respiratory Morbidity ◽  
Fitness Assessment
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