Re: ?What is the role of tests of lung function in the management of infants with lung disease?? by Godfrey et al. (Pediatr Pulmonol 2003;36:1-9): Interpretation and application of infant lung function tests

2004 ◽  
Vol 39 (1) ◽  
pp. 93-93
Author(s):  
Els van der Wiel ◽  
Ward Hofhuis ◽  
Eveline Nieuwhof ◽  
Johan de Jongste ◽  
Peter Merkus ◽  
...  
2006 ◽  
Vol 41 (3) ◽  
pp. 199-214 ◽  
Author(s):  
Sooky Lum ◽  
Georg Hülskamp ◽  
Peter Merkus ◽  
Eugenio Baraldi ◽  
Ward Hofhuis ◽  
...  

2006 ◽  
Vol 41 (4) ◽  
pp. 291-317 ◽  
Author(s):  
Monika Gappa ◽  
J. Jane Pillow ◽  
Julian Allen ◽  
Oscar Mayer ◽  
Janet Stocks

2017 ◽  
Vol 50 (6) ◽  
pp. 1701464 ◽  
Author(s):  
Sylvia Nyilas ◽  
Grzegorz Bauman ◽  
Gregor Sommer ◽  
Enno Stranzinger ◽  
Orso Pusterla ◽  
...  

Lung function tests are commonly used to monitor lung disease in cystic fibrosis (CF). While practical, they cannot locate the exact origin of functional impairment. Contemporary magnetic resonance imaging (MRI) techniques provide information on the location of disease but the need for contrast agents constrains their repeated application. We examined the correlation between functional MRI, performed without administration of contrast agent, and lung clearance index (LCI) from nitrogen multiple-breath washout (N2-MBW).40 children with CF (median (range) age 12.0 (6–18) years) and 12 healthy age-matched controls underwent functional and structural MRI and lung function tests on the same day. Functional MRI provided semiquantitative measures of perfusion (RQ) and ventilation (RFV) impairment as percentages of affected lung volume. Morphological MRI was evaluated using CF-specific scores. LCI measured global ventilation inhomogeneity.MRI detected functional impairment in CF:RFV19–38% andRQ16–35%.RFVandRQcorrelated strongly with LCI (r=0.76, p<0.0001 and r=0.85, p<0.0001, respectively), as did total morphology score (r=0.81, p<0.0001). All indices differed significantly between patients with CF and healthy controls (p<0.001).Noninvasive functional MRI is a promising method to detect and visualise perfusion and ventilation impairment in CF without the need for contrast agents.


Author(s):  
Frederik Trinkmann ◽  
Katharina Roth ◽  
Daniel Saur ◽  
Martin Borggrefe ◽  
Joachim Saur ◽  
...  

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