Assessment of changes in 1-second forced expiratory volume in bronchial provocation testing

1989 ◽  
Vol 6 (2) ◽  
pp. 71-73 ◽  
Author(s):  
Michael Wall
Keyword(s):  
Forced Expiratory Volume ◽  
Provocation Testing ◽  
Bronchial Provocation

Circulating Histamine and Neutrophil Chemotactic Activity During Allergen-Induced Asthma: The Effect of Inhaled Antihistamines and Anti-Allergic Compounds

1985 ◽  
Vol 69 (1) ◽  
pp. 63-69 ◽  
Author(s):  
D. J. R. Morgan ◽  
I. Moodley ◽  
D. R. Cundell ◽  
B. D. Sheinman ◽  
W. Smart ◽  
...  
Keyword(s):  
Airflow Obstruction ◽  
Isotonic Saline ◽  
Forced Expiratory Volume ◽  
Chemotactic Activity ◽  
Boyden Chamber ◽  
Plasma Histamine ◽  
Double Blind ◽  
Provocation Testing ◽  
Bronchial Provocation ◽  
Neutrophil Chemotactic Activity

1. Plasma histamine and serum neutrophil chemotactic activity (S-NCA) were measured in ten atopic asthmatic patients on four separate occasions after allergen bronchial provocation testing (BPT). 2. Single doses of inhaled sodium cromoglycate (SCG; 20 mg), clemastine (0.5 mg), ketotifen (0.5 mg) and isotonic saline (0.9% NaCl) placebo were administered 30 min before bronchial provocation testing in random order and double-blind. 3. The airflow obstruction after BPT was monitored by measurement of forced expiratory volume in 1s (FEV1). Plasma histamine was measured by the double-isotope radioenzymatic assay and S-NCA by a modified Boyden chamber technique. 4. A highly significant decrease in FEV1 after BPT occurred on the placebo pre-treatment visit (P < 0.001). Prior administration of inhaled SCG, clemastine and ketotifen significantly reduced the decrease in airflow obstruction seen after BPT when compared with placebo treatment (P < 0.01, P < 0.02, P < 0.05 respectively). 5. No significant alteration in plasma histamine was detected during allergen-induced airflow obstruction. 6. Levels of S-NCA were significantly higher 5, 10 and 15 min after BPT when compared with the pre-challenge level (P < 0.01, P < 0.01, P < 0.001 respectively). These levels were not significantly decreased when airflow obstruction was inhibited by the prior inhalation of SCG, clemastine or ketotifen.

scholarly journals The importance of impulse oscillometry in bronchial provocation testing in confirming the diagnosis of asthma in male army recruits

2017 ◽  
Vol 74 (2) ◽  
pp. 127-132
Author(s):  
Dragan Koruga ◽  
Kristina Tot-Veres ◽  
Goran Plavec ◽  
Olivera Loncarevic
Keyword(s):  
Provocation Test ◽  
Forced Expiratory Volume ◽  
Impulse Oscillometry ◽  
Average Increase ◽  
Provocation Tests ◽  
Military Recruits ◽  
One Step ◽  
Provocation Testing ◽  
Bronchial Provocation ◽  
Army Recruits

Background/Aim. Impulse oscillometry (IOS) is a technique valid for measuring the lung function in obstructive lung diseases and bronchial provocation tests. However, no consensus exists for its use. The aim of the study was to assess impulse oscillometry sensitivity for detection of early airways changes during bronchial provocation testing and to compare with changes obtained with spirometry and bodyplethysmography in male army recruits. Methods. Male military recruits were submitted to bronchial provocation test with histamine by the aerosol provocation system. Out of 52 male military recruits subjected to attempts to make the diagnosis of asthma the study included 31 subjects with fall of forced expiratory volume in one second (FEV1) above 20%. The changes of impulse oscillometry were measured one step before and after provocation dose (PD) of histamine and compared with the changes of bodyplethysmography and spirometry. Results. The average age of male army recruits was 23.3 year. After bronchoprovocation there was an average increase of the total resistance at 5 Hz (R5) by 66.6%, resonant frequency (Fres) by 102.2%, Goldman index (AX) by 912.1%, the arway resistance (Raw) by 121.5%, and a decrease in reactance at 5 Hz (X5) by 132.1% and FEV1 by 25.6%. One step before the last inhaled of PD20 there was an average increase of 26.7% in R5, 24.1% in Fres, 85.3% in AX, 11.9% in Raw and a decrease in X5 by 26.9% and FEV1 by 4.3%. A correlation between impulse oscillometry and bodyplethysmography parameters was obtained. Conclusion. This paper demonstrates a sufficient sensitivity of impulse oscillometry to detect changes in airways, so it may play a complementary role in the diagnosis of asthma in male military recruits.

A New Method For Bronchial-provocation Testing in Asthmatic Subjects Using a Dry Powder of Mannitol

1997 ◽  
Vol 156 (3) ◽  
pp. 758-765 ◽  
Author(s):  
SANDRA D. ANDERSON ◽  
JOHN BRANNAN ◽  
JOANNE SPRING ◽  
NATASHA SPALDING ◽  
LEANNE T. RODWELL ◽  
...  
Keyword(s):  
New Method ◽  
Dry Powder ◽  
Provocation Testing ◽  
Bronchial Provocation
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