Determination of airway hyper-reactivity in asthmatic children: A comparison among exercise, nebulized water, and histamine challenge

1988 ◽  
Vol 4 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Pieter R. Fourie ◽  
James R. Joubert
Keyword(s):  
Asthmatic Children ◽  
Histamine Challenge

scholarly journals Assessment of bronchodilatation after spontaneous recovery from a histamine challenge in asthmatic children.

Thorax ◽  
1992 ◽  
Vol 47 (5) ◽  
pp. 355-359 ◽  
Author(s):  
P J Merkus ◽  
H M Rooda ◽  
E E van Essen-Zandvliet ◽  
E J Duiverman ◽  
P H Quanjer ◽  
...  
Keyword(s):  
Spontaneous Recovery ◽  
Asthmatic Children ◽  
Histamine Challenge

scholarly journals 51 RECOVERY OF LUNG FUNCTION FROM HISTAMINE CHALLENGE IN ASTHMATIC CHILDREN

1986 ◽  
Vol 20 (10) ◽  
pp. 1042-1042
Author(s):  
Jorrit Gerritsen ◽  
Gerard H Koeter ◽  
Wim M C Van Aalderen ◽  
Klaas Kool
Keyword(s):  
Lung Function ◽  
Asthmatic Children ◽  
Histamine Challenge

Indirect Plasma-Theophylline Monitoring in Asthmatic Children by Determination of Theophylline Concentration in Saliva

PEDIATRICS ◽  
1974 ◽  
Vol 53 (6) ◽  
pp. 873-876
Author(s):  
Gerhard Levy ◽  
Elliot F. Ellis ◽  
Renu Koysooko
Keyword(s):  
Flow Rate ◽  
Maintenance Dose ◽  
Theophylline Concentration ◽  
Asthmatic Children ◽  
Plasma Theophylline ◽  
Mixed Saliva

The concentration of theophylline in mixed saliva and in plasma of 16 asthmatic children on regular theophylline therapy was obtained two and four hours after a maintenance dose. There is a strong and highly statistically significant correlation between the theophylline concentration in saliva and plasma. This correlation is not affected by the pH or flow rate of saliva. The concentration of theophylline in plasma could be predicted from the concentration in saliva within ± 10% in 20, and within ± 20% in all of the 32 samples. Determination of theophylline concentrations in saliva is an effective, convenient, noninvasive, and painless method for routine indirect monitoring of plasma-theophylline concentrations in asthmatic children on regular theophylline therapy.

A modified forced oscillation technique for measurements of respiratory resistance

1977 ◽  
Vol 42 (4) ◽  
pp. 650-655 ◽  
Author(s):  
H. Aronsson ◽  
L. Solymar ◽  
J. Dempsey ◽  
J. Bjure ◽  
T. Olsson ◽  
...  
Keyword(s):  
Forced Oscillation ◽  
Signal To Noise Ratio ◽  
Optimization Technique ◽  
Forced Oscillation Technique ◽  
Respiratory Resistance ◽  
Asthmatic Children ◽  
The Difference ◽  
Resistance Value ◽  
Automated Determination

We present a modification of forced oscillation technique for automated determination of total respiratory resistance during inspiration. The modifications consist of a computerized signal averaging and an optimization technique in the assessment of the resistance value. Thereby a favorable signal-to-noise ratio is obtained, allowing very low superimposed pressure oscillations. The method is validated by comparison with a conventional esophageal balloon method, by estimating added mechanical resistances in healthy subjects and by measuring the effect of bronchodilation in asthmatic children. The coefficient of variation as obtained from day-to-day measurements was about 7%. Mechanical resistances, estimated as the difference in total resistance with and without external resistance, were within 7% of their values determined for the resistances alone. A significant decrease in resistance was obtained in each of the asthmatic children following bronchodilation.

Evaluation of Passively Absorbed Saliva for Determination of Oral Slow-Release Theophylline Bioavailability in Children

1988 ◽  
Vol 22 (9) ◽  
pp. 684-686 ◽  
Author(s):  
Leigh M. Vaughan ◽  
Gary Milavetz ◽  
Miles M. Weinberger ◽  
Gary D. Smith ◽  
James G. Merrick
Keyword(s):  
Young Children ◽  
Correlation Coefficient ◽  
Slow Release ◽  
Relative Bioavailability ◽  
Blood Sampling ◽  
Noninvasive Method ◽  
Asthmatic Children ◽  
Serial Serum ◽  
Salivary Measurements

Assessment in young children of the bioavailability of slow-release theophylline formulations is hampered by the requirement for frequent blood sampling. Calculations of bioavailability from serial serum and passively absorbed saliva samples were therefore compared in six 9- to 12-year-old asthmatic children receiving multiple doses of Theo-Dur Sprinkle every 12 hours, using Theo-Dur tablets, a previously characterized formulation, as a reference. Results indicated 85 ± 5 percent and 82 ± 8 percent (mean ± SEM) relative bioavailability based on serum and salivary measurements, respectively. Correlation coefficient for serum and passively absorbed saliva bioavailabilities was 0.90. Passively absorbed saliva provides an acceptably accurate, noninvasive method for theophylline bioavailability assessment and may be a useful alternative for bioavailability studies in young children.

scholarly journals Reproducibility of histamine challenge tests in asthmatic children.

Thorax ◽  
1983 ◽  
Vol 38 (4) ◽  
pp. 258-260 ◽  
Author(s):  
D Hariparsad ◽  
N Wilson ◽  
C Dixon ◽  
M Silverman
Keyword(s):  
Asthmatic Children ◽  
Challenge Tests ◽  
Histamine Challenge

Gastroesophageal Reflux in Steroid-Dependent Asthmatic Youths

PEDIATRICS ◽  
1979 ◽  
Vol 63 (2) ◽  
pp. 207-212
Author(s):  
Gail G. Shapiro ◽  
Dennis L. Christie
Keyword(s):  
Gastroesophageal Reflux ◽  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Acid Reflux ◽  
Asthmatic Children ◽  
Function Tests ◽  
Steroid Dependent ◽  
Stomach Acid ◽  
Pulmonary Status

The aims of this study were to evaluate the incidence of gastroesophageal reflux (GER) in chronic allergic steroid-dependent asthmatic children and to assess whether a medical antireflux regimen might improve pulmonary status of asthmatics found to have reflux. Nineteen patients had a determination of lower esophageal sphincter (LES) pressure, pH assessment after acid instillation into the stomach (acid reflux test), and esophagram. After the reflux evaluation, an antireflux regimen was instituted for three weeks; patients were followed with asthma symptom diaries and weekly pulmonary function tests for this period and for another three weeks after finishing the regimen. Gastroesophageal reflux, diagnosed by positive acid reflux test, occurred in nine patients. Five patients had low LES pressure (≤12 mm Hg), and two patients had an abnormal esophagram. There were no significant changes in asthma syniptoms or pulmonary function tests with the medical antireflux regimen. Although GER does exist in a high percentage of this patient sample (47%), a short-term antacid and positional antireflux regimen does not improve the pulmonary status of these patients.

Sign in / Sign up

Export Citation Format

Share Document