Preserved diffusion capacity in children with cystic fibrosis

2003 ◽  
Vol 37 (1) ◽  
pp. 56-60 ◽  
Author(s):  
Peter J.F.M. Merkus ◽  
Elke S.J. Govaere ◽  
Wim H. Hop ◽  
Henk Stam ◽  
Harm A.W.M. Tiddens ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Diffusion Capacity

Diffusion Capacity and Oxygen Desaturation Effects on Exercise in Patients with Cystic Fibrosis

CHEST Journal ◽  
1987 ◽  
Vol 91 (5) ◽  
pp. 693-697 ◽  
Author(s):  
Patrick Lebecque ◽  
Jean-Guy Lapierre ◽  
André Lamarre ◽  
Allan L. Coates
Keyword(s):  
Cystic Fibrosis ◽  
Oxygen Desaturation ◽  
Diffusion Capacity

Respiratory

2020 ◽  
pp. 105-137
Author(s):  
Charlotte Frise ◽  
Sally Collins
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Failure ◽  
Lung Function ◽  
Management Strategies ◽  
Evidence Based ◽  
Lung Function Tests ◽  
Lung Volumes ◽  
Diffusion Capacity ◽  
And Diffusion ◽  
In Pregnancy

This chapter describes the respiratory changes that take place in pregnancy, infections, and pre-existing conditions that may be exacerbated or changed prior to birth. Lung function tests, including spirometry, static lung volumes, and diffusion capacity, are all described. Diseases such as tuberculosis, bronchiectasis, cystic fibrosis, and so on are described, with evidence-based management strategies. Respiratory failure and lung transplantation as well as difficulties associated with pre-existing conditions in pregnancy are also covered.

scholarly journals Influence of the Vibralung Acoustical Percussor on pulmonary function and sputum expectoration in individuals with cystic fibrosis

2018 ◽  
Vol 12 ◽  
pp. 175346661877099 ◽  
Author(s):  
Courtney M. Wheatley ◽  
Sarah E. Baker ◽  
Cori M. Daines ◽  
Hanna Phan ◽  
Marina G. Martinez ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pulmonary Function ◽  
Post Treatment ◽  
Sound Waves ◽  
Peripheral Oxygen Saturation ◽  
Diffusion Capacity ◽  
Unit Function ◽  
Therapy Sessions ◽  
Airway Clearance Therapy ◽  
Alveolar Capillary

Background: The Vibralung Acoustical Percussor is a new airway clearance therapy (ACT) utilizing intrapulmonary sound waves in addition to positive expiratory pressure (PEP). We evaluated the safety of the Vibralung and collected preliminary data on its ability to mediate sputum expectoration in individuals with cystic fibrosis (CF). Methods: Over two separate studies, 10 and 11 mild to moderate CF patients were recruited for study I and II, respectively. Study I: Vibralung was used for 20 min with either no sound (NS: PEP only) or sound (S: PEP and sound) on randomized visits. Pulmonary function, diffusion capacity of the lungs for carbon monoxide and nitric oxide (DLCO/DLNO), symptoms, and peripheral oxygen saturation (SpO2) were measured at baseline and at 1 and 4 h post treatment. Expectorated sputum was collected over 4 h post treatment. Study II: over 5 days of in-hospital therapy, the Vibralung or vibratory vest therapy (Vest) were used for two therapy sessions per day, with sputum collected for 20 min following each therapy and pulmonary function accessed pre and post each 5-day period (days 1–5 or 7–11) in a randomized crossover design. Results: Vibralung usage resulted in no change from baseline to 4 h post in pulmonary function, SpO2 or symptoms ( p > 0.05). At 4 h post therapy, the DLCO- and DLNO-derived measure of alveolar–capillary unit function (DM/ VC) showed improvement (DM/ VC = 12.5 ± 5.5 versus 7.3 ± 18.8% change, S versus NS) with no difference between S and NS ( p = 0.74). Sputum expectoration was similar between S and NS conditions (wet sputum = 10.5 ± 4.6 versus 9.9 ± 3.2 g, S versus NS, p = 0.25). There were no differences in the improvement in pulmonary function between Vibralung and Vest during either 5-day period during the hospital stay. Conclusions: Vibralung was well tolerated and caused no detrimental changes in pulmonary function metrics. The Vibralung appears to be a safe ACT in individuals with CF.

Pregnancy in cystic fibrosis of the pancreas

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 993-1000 ◽  
Author(s):  
R. J. Grand
Keyword(s):  
Cystic Fibrosis

Freeze-Fracture Examination of Tight Junctions of Human Eccrine Sweat Glands

1980 ◽  
Vol 38 ◽  
pp. 634-635
Author(s):  
J. V. Briggman ◽  
J. Bigelow ◽  
H. Bank ◽  
S. S. Spicer
Keyword(s):  
Cystic Fibrosis ◽  
Freeze Fracture ◽  
Sweat Glands ◽  
Hypertonic Solution ◽  
Dark Cells ◽  
Clear Cells ◽  
Junctional Complexes ◽  
Secretory Coil ◽  
Eccrine Sweat Glands ◽  
Eccrine Sweat

The prevalence of strands shown by freeze-fracture in the zonula occludens of junctional complexes is thought to correspond closely with the transepi-thelial electrical resistance and with the tightness of the junction and its obstruction to paracellular flow.1 The complexity of the network of junc¬tional complex strands does not appear invariably related to the degree of tightness of the junction, however, as rabbit ileal junctions have a complex network of strands and are permeable to lanthanum. In human eccrine sweat glands the extent of paracellular relative to transcellular flow remains unknown, both for secretion of the isotonic precursor fluid by the coil and for resorption of a hypertonic solution by the duct. The studies reported here undertook, therefore, to determine with the freeze-fracture technique the complexity of the network of ridges in the junctional complexes between cells in the secretory coil and the sweat ducts. Glands from a patient with cystic fibrosis were also examined because an alteration in junctional strands could underlie the decreased Na+ resorption by sweat ducts in this disease. Freeze-fracture replicas were prepared by standard procedures on isolated coil and duct segments of human sweat glands. Junctional complexes between clear cells, between dark cells and between clear and dark cells on the main lumen, and between clear cells on intercellular canaliculi of the coil con¬tained abundant anastomosing closely spaced strands averaging 6.4 + 0.7 (mean + SE) and 9.0 +0.5 (Fig. 1) per complex, respectively. Thus, the junctions in the intercellular canaliculi of the coil appeared comparable in complexity to those of tight epithlia. Occasional junctions exhibited, in addition, 2 to 5 widely spaced anastomosing strands in a very close network basal to the compact network. The fewer junctional complexes observed thus far between the superficial duct cells consisted on the average of 6 strands arranged in a close network and 1 to 4 underlying strands that lay widely separated from one another (Fig. 2). The duct epitelium would, thus, be judged slightly more "leaky" than the coil. Infrequent junctional complexes observed to date in the secretory coil segment of a cystic fibrosis specimen disclosed rela¬tively few closely crowded strands.

Chronic airway colonization by Penicillium emersonii in a patient with cystic fibrosis

1999 ◽  
Vol 37 (4) ◽  
pp. 291-293 ◽  
Author(s):  
B. Cimon ◽  
J. Carrere ◽  
J. P. Chazalette ◽  
J. F. Vinatier ◽  
D. Chabasse ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Airway Colonization ◽  
Chronic Airway

Heat stable toxin of E. coli (STa) stimulates duodenal mucosal bicarbonate secretion in cystic fibrosis knockout mice

2001 ◽  
Vol 120 (5) ◽  
pp. A137-A137
Author(s):  
D CHILDS ◽  
D CROMBIE ◽  
V PRATHA ◽  
Z SELLERS ◽  
D HOGAN ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Knockout Mice ◽  
Bicarbonate Secretion ◽  
E Coli ◽  
Heat Stable

Keppra, Tag-It Cystic Fibrosis Kit

2005 ◽  
Vol 39 (8) ◽  
pp. 43
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Cystic Fibrosis
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