Neurocognitive dysfunction in adult cerebellar medulloblastoma

2018 ◽  
Vol 28 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Rebecca A. Harrison ◽  
Shelli R. Kesler ◽  
Jason M. Johnson ◽  
Marta Penas-Prado ◽  
Catherine M. Sullaway ◽  
...  
Keyword(s):  
Neurocognitive Dysfunction ◽  
Cerebellar Medulloblastoma

Detection of Malingered Neurocognitive Dysfunction Among Patients with Acquired Brain Injuries

2013 ◽  
Vol 29 (4) ◽  
pp. 253-262 ◽  
Author(s):  
Omer Hegedish ◽  
Dan Hoofien
Keyword(s):  
Response Bias ◽  
Concurrent Validity ◽  
Convergent Validity ◽  
Brain Injuries ◽  
Neurocognitive Dysfunction ◽  
Word Memory Test ◽  
Malingered Neurocognitive Dysfunction ◽  
Compensation Seeking ◽  
Seeking Behavior ◽  
Verbal Test

The Word Memory Test (WMT) is one of the most sensitive forced-choice tests available designed to evaluate negative response bias (NRB). Presently there is no valid verbal test designed to evaluate NRB for Hebrew-speaking patients. The aims of the present study were to validate the response bias measures of the WMT among Hebrew-speaking patients with acquired brain injuries and to reveal the malingering base rate among Israeli patients involved in compensation-seeking. Participants were 112 patients. The Test of Memory Malingering (TOMM) was used for convergent validity and injury related variables were used for concurrent validity. A translated version of the WMT had high split-half reliability. Regarding convergent validity, WMT effort measures had high positive correlations with the TOMM. Moreover, based on TOMM cutoff scores for classification, the WMT had reasonable classification rates. Regarding concurrent validity, multivariate logistic regression revealed that failure in the WMT was significantly predicted by normal brainscans and involvement in compensation-seeking behavior. The baserate of probable malingering was 34%. These findings emphasize the universality of the WMT in detecting NRB and establishing a malingered neurocognitive dysfunction baserate among Israeli patients involved in compensation-seeking.

Pretreatment Worry Predicts Neurocognitive Dysfunction in Women with Breast Cancer

2013 ◽  
Author(s):  
M. G. Berman ◽  
M. K. Askren ◽  
M. S. Jung ◽  
B. Therrien ◽  
S. Peltier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neurocognitive Dysfunction

Extracellular matrix proteins control the growth of cerebellar medulloblastoma cells

2004 ◽  
Vol 216 (03) ◽  
Author(s):  
U Schüller ◽  
W Hartmann ◽  
A Koch ◽  
K Schilling ◽  
OD Wiestler ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Cerebellar Medulloblastoma

Diet and Neurocognition in Mood Disorders - An Overview of the Overlooked

2020 ◽  
Vol 26 (20) ◽  
pp. 2353-2362 ◽  
Author(s):  
Vicent Balanzá-Martínez ◽  
Flavio M. Shansis ◽  
Amparo Tatay-Manteiga ◽  
Pilar López-García
Keyword(s):  
Mood Disorders ◽  
Cognitive Outcomes ◽  
Clinical Staging ◽  
Current Evidence ◽  
Dietary Interventions ◽  
Unhealthy Lifestyle ◽  
Neurocognitive Dysfunction ◽  
Nutritional Interventions ◽  
Lifestyle Choices ◽  
Cognitive Benefits

Bipolar disorder and major depression are associated with significant disability, morbidity, and reduced life expectancy. People with mood disorders have shown higher ratios of unhealthy lifestyle choices, including poor diet quality and suboptimal nutrition. Diet and nutrition impact on brain /mental health, but cognitive outcomes have been less researched in psychiatric disorders. Neurocognitive dysfunction is a major driver of social dysfunction and a therapeutic target in mood disorders, although effective cognitive-enhancers are currently lacking. This narrative review aimed to assess the potential cognitive benefits of dietary and nutritional interventions in subjects diagnosed with mood disorders. Eight clinical trials with nutrients were identified, whereas none involved dietary interventions. Efficacy to improve select cognitive deficits has been reported, but results are either preliminary or inconsistent. Methodological recommendations for future cognition trials in the field are advanced. Current evidence and future views are discussed from the perspectives of precision medicine, clinical staging, nutritional psychiatry, and the brain-gut-microbiota axis.

scholarly journals RONC-26. A CASE OF RADIATION NECROSIS OF THE CEREBELLUM 16 YEARS AFTER CHEMORADIOTHERAPY FOR MEDULLOBLASTOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii460-iii460
Author(s):  
Mayuko Miyata ◽  
Masahiro Nonaka ◽  
Akio Asai
Keyword(s):  
Radiation Necrosis ◽  
Tumor Resection ◽  
Pathological Examination ◽  
Secondary Cancer ◽  
Brain Necrosis ◽  
Cerebellar Medulloblastoma ◽  
Cerebellar Peduncle ◽  
The Right ◽  
The Brain

Abstract BACKGROUND If new lesions are observed during follow-up of the malignant tumor after treatment, it is difficult to distinguish whether the tumor is a recurrent lesion, secondary cancer, or radiation necrosis of the brain. We have encountered a patient with symptomatic radiation necrosis of the cerebellum 16 years after treatment of medulloblastoma. CASE PRESENTATION: A 24-year-old man who had received a tumor resection and chemoradiotherapy for cerebellar medulloblastoma at the age of 8 presented with dizziness. For the past 16 years, there was no recurrence of the tumor. He subsequently underwent MRI scan, and T1-Gd image showed enhanced lesion in the right cerebellar peduncle. Cerebrospinal fluid cytology analysis was negative for tumor. We suspected tumor reccurence or secondary cancer, and performed lesion biopsy. The result of the pathological examination was radiation necrosis of the cerebellum. DISCUSSION: The interval of radiation necrosis of the brain and radiotherapy can vary from months to more than 10 years. So, whenever a new lesion is identified, radiation brain necrosis must be envisioned. According to guidelines in Japan, there is no absolute examination for discriminating tumor recurrence from radiation brain necrosis and diagnosis by biopsy may be required. CONCLUSION We experienced a case of symptomatic radiation necrosis of the cerebellum 16 years after treatment. In patients showing new lesion after long periods of time, the possibility of radiation necrosis to be considered.

scholarly journals Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction

2008 ◽  
Vol 2 (3) ◽  
pp. 271-280 ◽  
Author(s):  
Jeffrey A Rumbaugh ◽  
Joseph Steiner ◽  
Ned Sacktor ◽  
Avindra Nath
Keyword(s):  
Neurocognitive Dysfunction ◽  
Neuroprotective Strategies
Sign in / Sign up

Export Citation Format

Share Document