Using controlled radical polymerization to confirm the lower critical solution temperature of an N-(alkoxyalkyl) acrylamide polymer in aqueous solution

2014 ◽  
Vol 53 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Xeniya Savelyeva ◽  
Lucia Li ◽  
Milan Marić
Keyword(s):  
Aqueous Solution ◽  
Radical Polymerization ◽  
Lower Critical Solution Temperature ◽  
Controlled Radical Polymerization ◽  
Solution Temperature ◽  
Critical Solution Temperature

Synthesis and Characterization of Comb-Type Grafted Hydrogels

2012 ◽  
Vol 602-604 ◽  
pp. 1274-1284
Author(s):  
Ping Zhang ◽  
Shi Pu Li ◽  
Xin Yu Wang ◽  
Hong Lian Dai
Keyword(s):  
Aqueous Solution ◽  
Fluorescence Spectroscopy ◽  
Lower Critical Solution Temperature ◽  
Ammonium Persulfate ◽  
Solution Temperature ◽  
Synthesis And Characterization ◽  
Critical Solution Temperature

The grafted hydrogels of N-isopropylacrylamide (IPAAm) with 2-hydroxyethylacrylate (HEA) was prepared in an aqueous solution using ammonium persulfate (APS) and N,N,N’,N’-tetramethylethylene diamine (TEMED) as an accelerator. Lower critical solution temperature (LCST) and swelling ratios were measured as a function of temperature. The properties of the hydrogels contained pyrenyl probe in water were investigated by fluorescence spectroscopy.

Stability and Cell Adhesion Properties of Poly(N-isopropylacrylamide) Brushes with Variable Grafting Densities

2011 ◽  
Vol 64 (9) ◽  
pp. 1261 ◽  
Author(s):  
Xiaofeng Sui ◽  
Andrea Di Luca ◽  
Michel Klein Gunnewiek ◽  
E. Stefan Kooij ◽  
Clemens A. van Blitterswijk ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Lower Critical Solution Temperature ◽  
Polymer Brushes ◽  
Pure Water ◽  
Solution Temperature ◽  
Atom Transfer ◽  
Adhesion Properties ◽  
Critical Solution Temperature

Poly(N-isopropylacrylamide) brushes with three different grafting densities were synthesized via surface-initiated atom-transfer radical polymerization on glass or on silicon substrates. The substrates were modified with monochlorosilane-based or trimethoxysilane-based atom-transfer radical polymerization initiators. Atomic force microscopy images showed detachment of brushes from the monochlorosilane-based system under cell culture conditions. In situ ellipsometry demonstrated the reversible swelling and collapse of the brushes as the temperature was varied across the lower critical solution temperature of poly(N-isopropylacrylamide) in pure water. The polymer brushes were evaluated as supporting substrates for MC-3T3 cell cultures. At 37°C (T>lower critical solution temperature), the seeded cells adhered, spread, and proliferated, whereas at 25°C (T<lower critical solution temperature), the cells detached from the surface. The low-density polymer brush showed the highest cell adhesion, featuring adhering cells with an elongated morphology.

scholarly journals Atomistic simulation for coil-to-globule transition of poly(2-dimethylaminoethyl methacrylate)

Soft Matter ◽  
2015 ◽  
Vol 11 (12) ◽  
pp. 2423-2433 ◽  
Author(s):  
Sa Hoon Min ◽  
Sang Kyu Kwak ◽  
Byeong-Su Kim
Keyword(s):  
Molecular Dynamics ◽  
Aqueous Solution ◽  
Lower Critical Solution Temperature ◽  
Atomistic Simulation ◽  
Md Simulations ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Dimethylaminoethyl Methacrylate

We investigate the coil-to-globule transition of poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) in the aqueous solution through the lower critical solution temperature (LCST) by atomistic molecular dynamics (MD) simulations.

Polymerization of Acrylamide in Aqueous Solution of Poly(N‐isopropylacrylamide) at Lower Critical Solution Temperature

2008 ◽  
Vol 45 (7) ◽  
pp. 523-528 ◽  
Author(s):  
Manabu Ishifune ◽  
Ryuhei Suzuki ◽  
Mikio Yamane ◽  
Hiroyuki Tanabe ◽  
Yuki Nakagawa ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Lower Critical Solution Temperature ◽  
Solution Temperature ◽  
Critical Solution Temperature

Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles

2015 ◽  
Vol 6 (11) ◽  
pp. 2048-2053 ◽  
Author(s):  
Yang Shi ◽  
Renata M. Cardoso ◽  
Cornelus F. van Nostrum ◽  
Wim E. Hennink
Keyword(s):  
Aqueous Solution ◽  
Block Copolymer ◽  
Lower Critical Solution Temperature ◽  
Polymeric Micelles ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Uv Illumination ◽  
Uv Lamp

An anthracene-functionalized thermosensitive block copolymer was synthesized, which formed micelles by heating its aqueous solution above the lower critical solution temperature (LCST). The micelles were subsequently crosslinked by UV illumination at 365 nm with a normal handheld UV lamp.

Dynamical heterogeneity in the gelation process of a polymer solution with a lower critical solution temperature

Soft Matter ◽  
2021 ◽  
Vol 17 (11) ◽  
pp. 3222-3233
Author(s):  
Yingkang Dai ◽  
Runlin Zhang ◽  
Weixiang Sun ◽  
Tao Wang ◽  
Yunhua Chen ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Hyaluronic Acid ◽  
Particle Tracking ◽  
Lower Critical Solution Temperature ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Dynamical Heterogeneity ◽  
Hydrophobically Modified ◽  
Particle Tracking Microrheology ◽  
Acid Aqueous Solution

The gelation of a hydrophobically modified hyaluronic acid aqueous solution which shows a lower critical solution temperature of about 25 °C was investigated by multi-particle tracking microrheology.

Modified Poly (N-Isopropylacrylamide) Hydrogels for Drug Delivery

2010 ◽  
Author(s):  
Guoguang Fu ◽  
Winston Soboyejo
Keyword(s):  
Phase Transition ◽  
Drug Delivery ◽  
Aqueous Solution ◽  
Drug Release ◽  
Lower Critical Solution Temperature ◽  
Environmental Temperature ◽  
Swelling Behavior ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Release Profiles

Thermo-responsive hydrogel can change their swelling behavior and drug release characteristics in response to environmental temperature [1–5]. Poly(N-isopropylacrylamide) (PNIPA) hydrogel undergoes a phase transition when the temperatue is lower than a lower critical solution temperature (LCST) of ∼32°C in aqueous solution [8], and drug release profiles in PNIPA hydrogel can be controlled by the alternation of their solution temperatures.

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