Facile synthesis of ABCDE-type H-shaped quintopolymers by combination of ATRP, ROP, and click chemistry and their potential applications as drug carriers

2012 ◽  
Vol 50 (22) ◽  
pp. 4705-4716 ◽  
Author(s):  
Huanhuan Liu ◽  
Shixian Li ◽  
Meijing Zhang ◽  
Wei Shao ◽  
Youliang Zhao
Keyword(s):  
Click Chemistry ◽  
Drug Carriers ◽  
Facile Synthesis ◽  
Potential Applications

scholarly journals Immunomodulatory Nanomedicine for the Treatment of Atherosclerosis

2021 ◽  
Vol 10 (14) ◽  
pp. 3185
Author(s):  
Linsey J. F. Peters ◽  
Alexander Jans ◽  
Matthias Bartneck ◽  
Emiel P. C. van der Vorst
Keyword(s):  
Cell Proliferation ◽  
Drug Carriers ◽  
Research Field ◽  
General Introduction ◽  
Cellular Receptors ◽  
Cellular Processes ◽  
Potential Applications ◽  
Current Therapies ◽  
Based Medicine ◽  
Physiological Systems

Atherosclerosis is the main underlying cause of cardiovascular diseases (CVDs), which remain the number one contributor to mortality worldwide. Although current therapies can slow down disease progression, no treatment is available that can fully cure or reverse atherosclerosis. Nanomedicine, which is the application of nanotechnology in medicine, is an emerging field in the treatment of many pathologies, including CVDs. It enables the production of drugs that interact with cellular receptors, and allows for controlling cellular processes after entering these cells. Nanomedicine aims to repair, control and monitor biological and physiological systems via nanoparticles (NPs), which have been shown to be efficient drug carriers. In this review we will, after a general introduction, highlight the advantages and limitations of the use of such nano-based medicine, the potential applications and targeting strategies via NPs. For example, we will provide a detailed discussion on NPs that can target relevant cellular receptors, such as integrins, or cellular processes related to atherogenesis, such as vascular smooth muscle cell proliferation. Furthermore, we will underline the (ongoing) clinical trials focusing on NPs in CVDs, which might bring new insights into this research field.

scholarly journals Click Chemistry Enabling Covalent and Non-Covalent Modifications of Graphene with (Poly)saccharides

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 142
Author(s):  
Hu Li ◽  
Raffaello Papadakis
Keyword(s):  
Click Chemistry ◽  
Life Science ◽  
Environmental Applications ◽  
Energy Materials ◽  
Sensors And Actuators ◽  
Polar Solvents ◽  
Wide Range ◽  
Potential Applications ◽  
Covalent Modifications

Graphene is a material with outstanding properties and numerous potential applications in a wide range of research and technology areas, spanning from electronics, energy materials, sensors, and actuators to life-science and many more. However, the insolubility and poor dispersibility of graphene are two major problems hampering its use in certain applications. Tethering mono-, di-, or even poly-saccharides on graphene through click-chemistry is gaining more and more attention as a key modification approach leading to new graphene-based materials (GBM) with improved hydrophilicity and substantial dispersibility in polar solvents, e.g., water. The attachment of (poly)saccharides on graphene further renders the final GBMs biocompatible and could open new routes to novel biomedical and environmental applications. In this review, recent modifications of graphene and other carbon rich materials (CRMs) through click chemistry are reviewed.

scholarly journals SnSe Nanosheets: From Facile Synthesis to Applications in Broadband Photodetections

Nanomaterials ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 49
Author(s):  
Xiangyang Li ◽  
Zongpeng Song ◽  
Huancheng Zhao ◽  
Wenfei Zhang ◽  
Zhenhua Sun ◽  
...  
Keyword(s):  
Transient Absorption ◽  
Ultrafast Optics ◽  
Light Response ◽  
Transient Absorption Spectroscopy ◽  
Monolayer Graphene ◽  
Proof Of Concept ◽  
Facile Synthesis ◽  
Femtosecond Transient Absorption ◽  
Potential Applications ◽  
Promising Area

In recent years, using two-dimensional (2D) materials to realize broadband photodetection has become a promising area in optoelectronic devices. Here, we successfully synthesized SnSe nanosheets (NSs) by a facile tip ultra-sonication method in water-ethanol solvent which was eco-friendly. The carrier dynamics of SnSe NSs was systematically investigated via a femtosecond transient absorption spectroscopy in the visible wavelength regime and three decay components were clarified with delay time of τ1 = 0.77 ps, τ2 = 8.3 ps, and τ3 = 316.5 ps, respectively, indicating their potential applications in ultrafast optics and optoelectronics. As a proof-of-concept, the photodetectors, which integrated SnSe NSs with monolayer graphene, show high photoresponsivities and excellent response speeds for different incident lasers. The maximum photo-responsivities for 405, 532, and 785 nm were 1.75 × 104 A/W, 4.63 × 103 A/W, and 1.52 × 103 A/W, respectively. The photoresponse times were ~22.6 ms, 11.6 ms, and 9.7 ms. This behavior was due to the broadband light response of SnSe NSs and fast transportation of photocarriers between the monolayer graphene and SnSe NSs.

scholarly journals ‘Click’ chemistry as a tool for the facile synthesis of fullerene glycoconjugate derivatives

2010 ◽  
Vol 51 (7) ◽  
pp. 1022-1025 ◽  
Author(s):  
Guilherme Rocha Pereira ◽  
Leandro José Santos ◽  
Inácio Luduvico ◽  
Rosemeire Brondi Alves ◽  
Rossimiriam Pereira de Freitas
Keyword(s):  
Click Chemistry ◽  
Facile Synthesis

scholarly journals Facile Synthesis of Sprayed CNTs Layer-Embedded Stretchable Sensors with Controllable Sensitivity

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 311 ◽  
Author(s):  
Hammad R. Khalid ◽  
Iqra Choudhry ◽  
Daeik Jang ◽  
Nadir Abbas ◽  
M. Salman Haider ◽  
...  
Keyword(s):  
Electrical Resistance ◽  
Electronic Devices ◽  
Polymer Layer ◽  
Facile Synthesis ◽  
Optical Images ◽  
Significant Interest ◽  
Potential Applications ◽  
Facile Fabrication ◽  
Stretchable Sensors ◽  
Solution Volume

Flexible electronic devices have gained significant interest due to their different potential applications. Herein, we report highly flexible, stretchable, and sensitive sensors made of sprayed CNT layer, sandwiched between two polymer layers. A facile fabrication process was employed in which the CNT solution was directly sprayed onto a patterned bottom polymer layer, above which a second polymer layer was casted to get a sandwiched composite structure. Varying amounts of CNT solution (i.e., 10, 25, 40, 70, and 100 mL) were sprayed to get conductive CNT layers of different thicknesses/densities. The physical characteristics of the conductive CNT layers were studied through SEM and optical images. The starting electrical resistance values (without strain) as well as the changes in electrical resistance against human body motions were monitored. The synthesized samples exhibited good response against finger and wrist bending. The conductivity of the samples increased with increase of CNT solution volume while the sensitivity followed the inverse relation, suggesting that the sensors with controlled sensitivity could be fabricated for targeted strain ranges using the proposed method.

scholarly journals Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization

2017 ◽  
Vol 8 ◽  
pp. 772-783 ◽  
Author(s):  
Mohamed Hamed Misbah ◽  
Mercedes Santos ◽  
Luis Quintanilla ◽  
Christina Günter ◽  
Matilde Alonso ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Click Chemistry ◽  
Recombinant Dna ◽  
Fibrillar Structure ◽  
Cross Link ◽  
Recombinant Dna Technology ◽  
Peptide Epitope ◽  
Phosphate Mineralization ◽  
Potential Applications ◽  
Dna Technology

Understanding the mechanisms responsible for generating different phases and morphologies of calcium phosphate by elastin-like recombinamers is supreme for bioengineering of advanced multifunctional materials. The generation of such multifunctional hybrid materials depends on the properties of their counterparts and the way in which they are assembled. The success of this assembly depends on the different approaches used, such as recombinant DNA technology and click chemistry. In the present work, an elastin-like recombinamer bearing lysine amino acids distributed along the recombinamer chain has been cross-linked via Huisgen [2 + 3] cycloaddition. The recombinamer contains the SNA15 peptide domains inspired by salivary statherin, a peptide epitope known to specifically bind to and nucleate calcium phosphate. The benefit of using click chemistry is that the hybrid elastin-like-statherin recombinamers cross-link without losing their fibrillar structure. Mineralization of the resulting hybrid elastin-like-statherin recombinamer hydrogels with calcium phosphate is described. Thus, two different hydroxyapatite morphologies (cauliflower- and plate-like) have been formed. Overall, this study shows that crosslinking elastin-like recombinamers leads to interesting matrix materials for the generation of calcium phosphate composites with potential applications as biomaterials.

scholarly journals The Application of Chitosan Nanostructures in Stomatology

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6315
Author(s):  
Shunli Chu ◽  
Jue Wang ◽  
Fengxiang Gao
Keyword(s):  
Positive Charge ◽  
Antibacterial Properties ◽  
Drug Carriers ◽  
Natural Polymer ◽  
Hard Tissue ◽  
Recent Developments ◽  
Potential Applications ◽  
Soft Tissue Diseases ◽  
Application Fields ◽  
Dental Restorative

Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. They offer advantages in stomatology due to their excellent biocompatibility, their antibacterial properties, and their biodegradability. Nano-CSs can be applied as drug carriers for soft tissue diseases, bone tissue engineering and dental hard tissue remineralization; furthermore, they have been used in endodontics due to their antibacterial properties; and, finally, nano-CS can improve the adhesion and mechanical properties of dental-restorative materials due to their physical blend and chemical combinations. In this review, recent developments in the application of nano-CS for stomatology are summarized, with an emphasis on nano-CS’s performance characteristics in different application fields. Moreover, the challenges posed by and the future trends in its application are assessed.

Facile Synthesis of Well-Defined Hydrophilic Methacrylic Macromonomers Using ATRP and Click Chemistry

2008 ◽  
Vol 41 (24) ◽  
pp. 9542-9547 ◽  
Author(s):  
Paul D. Topham ◽  
Nicolas Sandon ◽  
Elizabeth S. Read ◽  
Jeppe Madsen ◽  
Anthony J. Ryan ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Facile Synthesis

Cancer theranosis using mono-disperse, mesoporous gold nanoparticles obtained via a robust, high-yield synthetic methodology

RSC Advances ◽  
2016 ◽  
Vol 6 (16) ◽  
pp. 13554-13561 ◽  
Author(s):  
Taeksu Lee ◽  
Doyeon Bang ◽  
Yong Wook Chang ◽  
Yuna Choi ◽  
Kwang Yeol Park ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
High Yield ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Potential Applications

Here, we introduce the facile synthesis of scalable, mono-disperse, mesoporous gold nanoparticles (MPGNs) with an acidic emulsification method, which exhibit many attractive nanoplasmonic features for potential applications in many fields.

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