Synthesis of pH-responsive photocrosslinked hyaluronic acid-based hydrogels for drug delivery

2012 ◽  
Vol 50 (17) ◽  
pp. 3507-3516 ◽  
Author(s):  
Youhua Tao ◽  
Ling Ai ◽  
Huiyu Bai ◽  
Xiaoya Liu
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Ph Responsive

pH responsive chitosan and hyaluronic acid layer by layer film for drug delivery applications

2019 ◽  
Vol 135 ◽  
pp. 240-247 ◽  
Author(s):  
Bingyang Lu ◽  
Dan Luo ◽  
Ansha Zhao ◽  
Haohao Wang ◽  
Yuancong Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Layer By Layer ◽  
Ph Responsive ◽  
Layer Film ◽  
Drug Delivery Applications

Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery

2019 ◽  
Vol 55 (8) ◽  
pp. 1164-1167 ◽  
Author(s):  
Yu-Hui Zhang ◽  
Ying-Ming Zhang ◽  
Jie Yu ◽  
Jie Wang ◽  
Yu Liu
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Anticancer Effect ◽  
Targeted Drug

A polysaccharide nanoconjugate was fabricated from N-(2-aminoethyl)-gluconamide-grafted hyaluronic acid and bortezomib, displaying pH-responsive targeted drug release and higher anticancer effect.

Hyaluronic acid-conjugated apoferritin nanocages for lung cancer targeted drug delivery

2015 ◽  
Vol 3 (10) ◽  
pp. 1386-1394 ◽  
Author(s):  
Yanan Luo ◽  
Xuenv Wang ◽  
Dan Du ◽  
Yuehe Lin
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Controlled Release ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Protein Cage ◽  
Targeted Drug

In this paper, we proposed a naturally derived protein cage based pH-responsive delivery system for intracellular prodrug controlled release.

Construction of a tumor microenvironment pH-responsive cleavable PEGylated hyaluronic acid nano-drug delivery system for colorectal cancer treatment

2020 ◽  
Vol 8 (7) ◽  
pp. 1885-1896 ◽  
Author(s):  
Xinyu Zhang ◽  
Minyi Zhao ◽  
Nan Cao ◽  
Wei Qin ◽  
Meng Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Nano Drug Delivery ◽  
Imine Bond ◽  
Microenvironment Ph ◽  
Colorectal Cancer Treatment

To improve the tumor cell active targeting, uptake efficiency and circulation time of doxorubicin (DOX) in vivo. Herein, we constructed a cleavable PEGylated hyaluronic acid nano-drug delivery system (HA–mPEG2k–DOX) based on pH-responsive imine bond.

scholarly journals Metal-Phenolic Network-Coated Hyaluronic Acid Nanoparticles for pH-Responsive Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 636 ◽  
Author(s):  
Jung Min Shin ◽  
Gwan Hyun Choi ◽  
Seok Ho Song ◽  
Hyewon Ko ◽  
Eun Sook Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Drug Carrier ◽  
Clinical Applications ◽  
Targeted Cancer Therapy ◽  
Ph Responsive ◽  
Tumor Microenvironments ◽  
Rapid Release ◽  
Potential Use

Although self-assembled nanoparticles (SNPs) have been used extensively for targeted drug delivery, their clinical applications have been limited since most of the drugs are released into the blood before they reach their target site. In this study, metal-phenolic network (MPN)-coated SNPs (MPN-SNPs), which consist of an amphiphilic hyaluronic acid derivative, were prepared to be a pH-responsive nanocarrier to facilitate drug release in tumor microenvironments (TME). Due to their amphiphilic nature, SNPs were capable of encapsulating doxorubicin (DOX), chosen as the model anticancer drug. Tannic acid and FeCl3 were added to the surface of the DOX-SNPs, which allowed them to be readily coated with MPNs as the diffusion barrier. The pH-sensitive MPN corona allowed for a rapid release of DOX and effective cellular SNP uptake in the mildly acidic condition (pH 6.5) mimicking TME, to which the hyaluronic acid was exposed to facilitate receptor-mediated endocytosis. The DOX-loaded MPN-SNPs exhibited a higher cytotoxicity for the cancer cells, suggesting their potential use as a drug carrier in targeted cancer therapy.

scholarly journals pH-Responsive i-motif Conjugated Hyaluronic Acid/Polyethylenimine Complexes for Drug Delivery Systems

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 247 ◽  
Author(s):  
Gyeong Jin Lee ◽  
Tae-il Kim
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
A549 Cells ◽  
Hybrid Structure ◽  
Delivery Systems ◽  
Amide Bond ◽  
Ph Responsive ◽  
Ph Change

i-motif is cytosine (C)-rich oligonucleotide (ODN) which shows pH-responsive structure change in acidic condition. Therefore, it has been utilized for the trigger of intercalated drug release, responding to environmental pH change. In this study, 2.76 molecules of i-motif binding ODNs (IBOs) were conjugated to each hyaluronic acid (HA) via amide bond linkages. Synthesis of HA-IBO conjugate (HB) was confirmed by FT-IR and agarose gel electrophoresis with Stains-All staining. After hybridization of HB with i-motif ODN (IMO), it was confirmed that doxorubicin (DOX) could be loaded in HB-IMO hybrid structure (HBIM) with 65.6% of drug loading efficiency (DLE) and 25.0% of drug loading content (DLC). At pH 5.5, prompt and significant DOX release from HBIM was observed due to the disruption of HBIM hybrid structure via i-motif formation of IMO, contrary to pH 7.4 condition. Then, HBIM was complexed with low molecular weight polyethylenimine (PEI1.8k), forming positively charged nanostructures (Z-average size: 126.0 ± 0.4 nm, zeta-potential: 16.1 ± 0.3 mV). DOX-loaded HBIM/PEI complexes displayed higher anticancer efficacy than free DOX in A549 cells, showing the potential for pH-responsive anticancer drug delivery systems.

Sign in / Sign up

Export Citation Format

Share Document