Construction of a tumor microenvironment pH-responsive cleavable PEGylated hyaluronic acid nano-drug delivery system for colorectal cancer treatment

2020 ◽  
Vol 8 (7) ◽  
pp. 1885-1896 ◽  
Author(s):  
Xinyu Zhang ◽  
Minyi Zhao ◽  
Nan Cao ◽  
Wei Qin ◽  
Meng Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Nano Drug Delivery ◽  
Imine Bond ◽  
Microenvironment Ph ◽  
Colorectal Cancer Treatment

To improve the tumor cell active targeting, uptake efficiency and circulation time of doxorubicin (DOX) in vivo. Herein, we constructed a cleavable PEGylated hyaluronic acid nano-drug delivery system (HA–mPEG2k–DOX) based on pH-responsive imine bond.

Fabrication of a pH responsive DOX conjugated PEGylated palladium nanoparticle mediated drug delivery system: an in vitro and in vivo evaluation

RSC Advances ◽  
2015 ◽  
Vol 5 (56) ◽  
pp. 44998-45014 ◽  
Author(s):  
Krishnamurthy Shanthi ◽  
Karuppaiya Vimala ◽  
Dhanaraj Gopi ◽  
Soundarapandian Kannan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hela Cells ◽  
Ph Responsive ◽  
Palladium Nanoparticle ◽  
In Vivo Evaluation ◽  
Induced Apoptosis

Schematic illustration of the possible mechanism of pH based drug delivery system of DOX conjugated PEGylated PdNPs induced apoptosis in HeLa cells.

scholarly journals Targeted nano-drug delivery system for glioblastoma therapy: In vitro and in vivo study

2020 ◽  
Vol 60 ◽  
pp. 102039
Author(s):  
Majid Hassanzadeganroudsari ◽  
Majid Soltani ◽  
Amir Heydarinasab ◽  
Vasso Apostolopoulos ◽  
Azim Akbarzadehkhiyavi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Study ◽  
Nano Drug Delivery

Anti-tumor drug delivery system based on cyclodextrin-containing pH-responsive star polymer: In vitro and in vivo evaluation

2014 ◽  
Vol 474 (1-2) ◽  
pp. 232-240 ◽  
Author(s):  
Qingqing Xiong ◽  
Mingming Zhang ◽  
Zhibao Zhang ◽  
Wei Shen ◽  
Lingrong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Star Polymer ◽  
Ph Responsive ◽  
In Vivo Evaluation ◽  
Tumor Drug Delivery

Construction of Intelligent Nano-Drug Delivery System for Targeting Extranodal Nasal Natural Killer/Thymus Dependent Lymphocyte

2021 ◽  
Vol 17 (3) ◽  
pp. 487-500
Author(s):  
Xinyu Zhang ◽  
Jun Wu ◽  
Dongjun Lin
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Reticuloendothelial System ◽  
Treatment Programs ◽  
Multi Drug Resistance ◽  
Nano Drug Delivery ◽  
Further Development

Extranodal nasal NK/T-cell lymphoma is highly aggressive and malignant. Owing to the lack of multi-center prospective controlled studies, there is not a unified standard for the current clinical best treatment model. In recent years, new nano-drug delivery systems have made great progress in the field of tumor treatment. However, research on ENKTL is still in its infancy. The authors' previous research has proven that the dextran nano-drug delivery system can optimize and improve the in vivo pharmacokinetic behavior and anti-tumor effects of doxorubicin through interaction with the reticuloendothelial system and the complex tumor microenvironment. At the same time, gemcitabine, which is commonly used in the clinical treatment of ENKTL, and cisplatin, which is a radiosensitizer, both contain free amino groups, which can be successfully grafted to aldehyde-based natural polysaccharides. Therefore, based on the natural nano-drug carrier, we constructed a smart long-circulation drug delivery system that co-loaded gemcitabine and cisplatin and targeted ENKTL to achieve effective treatment of ENKTL under the dual treatment mode of chemotherapy and radiosensitization. This project improves the radiosensitivity of ENKTL and overcomes the multi-drug resistance of chemotherapeutics through the radiotherapy-cooperative natural nano-drug delivery system and provides a new idea for the further development and optimization of ENKTL treatment programs.

Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy

2018 ◽  
Vol 139 ◽  
pp. 172-180 ◽  
Author(s):  
Jinghai Yang ◽  
Fei Gao ◽  
Donglai Han ◽  
Lili Yang ◽  
Xiangwang Kong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Tumor Inhibition
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