Thermal and acid labile polyurethanes as a new class of responsive materials in polymeric nanoparticles and nanocapsules

2011 ◽  
Vol 50 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Joerg Max Siebert ◽  
Grit Baier ◽  
Katharina Landfester
Keyword(s):  
Polymeric Nanoparticles ◽  
Responsive Materials ◽  
New Class ◽  
Acid Labile

scholarly journals Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 142 ◽  
Author(s):  
Nermin E. Eleraky ◽  
Ayat Allam ◽  
Sahar B. Hassan ◽  
Mahmoud M. Omar
Keyword(s):  
Liquid Crystalline ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
World Health ◽  
Antibacterial Resistance ◽  
Combination Drug ◽  
Responsive Materials ◽  
Innovative Strategies ◽  
Liquid Crystalline Nanoparticles ◽  
Health Organization

Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted the researchers to explore new innovative strategies to overcome such resilient microbes. Hence, novel antibiotic delivery systems are in high demand. Nanotechnology has attracted considerable interest due to their favored physicochemical properties, drug targeting efficiency, enhanced uptake, and biodistribution. The present review focuses on the recent applications of organic (liposomes, lipid-based nanoparticles, polymeric micelles, and polymeric nanoparticles), and inorganic (silver, silica, magnetic, zinc oxide (ZnO), cobalt, selenium, and cadmium) nanosystems in the domain of antibacterial delivery. We provide a concise description of the characteristics of each system that render it suitable as an antibacterial delivery agent. We also highlight the recent promising innovations used to overcome antibacterial resistance, including the use of lipid polymer nanoparticles, nonlamellar liquid crystalline nanoparticles, anti-microbial oligonucleotides, smart responsive materials, cationic peptides, and natural compounds. We further discuss the applications of antimicrobial photodynamic therapy, combination drug therapy, nano antibiotic strategy, and phage therapy, and their impact on evading antibacterial resistance. Finally, we report on the formulations that made their way towards clinical application.

Thiophene Backbone Amide Linkers, a New Class of Easily Prepared and Highly Acid-Labile Linkers for Solid-Phase Synthesis†

2006 ◽  
Vol 71 (18) ◽  
pp. 6734-6741 ◽  
Author(s):  
Mikkel Jessing ◽  
Malene Brandt ◽  
Knud J. Jensen ◽  
Jørn B. Christensen ◽  
Ulrik Boas
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
New Class ◽  
Backbone Amide ◽  
Acid Labile

Chain Failure Events in Microfluidic Membrane Networks

2016 ◽  
Author(s):  
Michelle Makhoul-Mansour ◽  
Elio J. Challita ◽  
Eric C. Freeman
Keyword(s):  
Structural Integrity ◽  
Computational Prediction ◽  
Equilibrium Structure ◽  
Stimuli Responsive ◽  
Large Networks ◽  
Responsive Materials ◽  
New Class ◽  
Interfacial Energies ◽  
Membrane Networks ◽  
The Impact

Multiple lipid encased water droplets may be linked together in oil to form large networks of droplet interface bilayers thus creating a new class of stimuli-responsive materials for applications in sensing, actuation, drug delivery, and tissue engineering. While single droplet interface bilayers have been extensively studied, comparatively little is known about their interaction in large networks. One particular problem of interest is understanding the impact of the coalescence of two neighboring droplets on the overall structural integrity of the network. Here, we propose a computational modeling scheme that predicts and characterizes the mechanical properties of the multiple lipid bilayer interfaces within the droplet network upon intentional coalescence of adjacent droplets. Droplet networks with tailored architectures are synthesized with the aid of magnetic motor droplets containing a biocompatible ferrofluid. The equilibrium configuration of the droplet networks is compared to computational prediction which defines the overall stability by summing the interfacial energies. Once the networks are completed, failure in selected membranes is induced. As the targeted droplets coalesce together, the equilibrium structure of the network is altered and the remaining droplets may shift to new configurations dictated by their minimized mechanical energies.

ChemInform Abstract: Lithiation and Stereoselective Transformations of 3-Aroyl-2,2,4,4-tetramethyloxazolidines (TMO Amides), a New Class of Acid-Labile Atropisomeric Amides.

ChemInform ◽  
2010 ◽  
Vol 33 (25) ◽  
pp. no-no
Author(s):  
Mark Anstiss ◽  
Jonathan Clayden ◽  
Alexander Grube ◽  
Latifa H. Youssef
Keyword(s):  
New Class ◽  
Acid Labile

scholarly journals Analytical Methods to Characterize and Purify Polymeric Nanoparticles

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Cristina Fornaguera ◽  
Conxita Solans
Keyword(s):  
Polymeric Nanoparticles ◽  
Clinical Applications ◽  
Bulk Materials ◽  
Analytical Characterization ◽  
New Class ◽  
Characterization Techniques ◽  
Current Review ◽  
Purification Methods ◽  
Therapeutic Tools

Advances in polymeric nanoparticles as novel nanomedicines have opened a new class of diagnostic and therapeutic tools for many diseases. However, although the benchtop research studies in the nanoworld are numerous, their translation to currently marketed products is still limited. This lack of transference can be attributed, among other factors, to problems with nanomedicine characterization. Characterization techniques at the nanoscale could be divided in three categories: characterization of physicochemical properties (e.g., size and surface charge), characterization of nanomaterials interactions with biological components (e.g., proteins from the blood), and analytical characterization and purification methods. Currently available literature of this last group only describes methodologies applied for a specific type of nanomaterial or even methods used for bulk materials, which are not completely applicable to nanomaterials. For this reason, the current review aims to become a scholastic guide for those scientists starting in the nanoworld, giving them a description of analytical characterization techniques aimed to analyze polymers forming nanoparticles and possible forms to purify them before being used in preclinical and clinical applications.

Synthesis and Properties of Photoswitchable Carbohydrate Fluorosurfactants

2015 ◽  
Vol 68 (12) ◽  
pp. 1880 ◽  
Author(s):  
Yingxue Hu ◽  
Joshua B. Marlow ◽  
Rajesh Ramanathan ◽  
Wenyue Zou ◽  
Hui Geok Tiew ◽  
...  
Keyword(s):  
Water Solubility ◽  
Cycloaddition Reaction ◽  
Parallel Synthesis ◽  
Head Group ◽  
Responsive Materials ◽  
Good Thermal Stability ◽  
New Class ◽  
Antibacterial Performance ◽  
Broad Interest ◽  
Cis Isomer

We describe the parallel synthesis, photocontrollable surface tension, and antibacterial performance of a new class of carbohydrate fluorosurfactant. Novel fluorosurfactants comprised a mono- or disaccharide head group linked to an azobenzene unit that was variably substituted with a trifluoromethyl group. Fluorosurfactants were rapidly assembled using the venerable CuI-catalysed azide–alkyne cycloaddition reaction and exhibited light-addressable surface activity, excellent water solubility, and selective antibacterial activity against Gram-positive Staphylococcus aureus. Notably, the physicochemical and biological activity of these novel materials was heavily dependent on the nature of the head group and the position of the trifluoromethyl substituent on the azobenzene ring. The UV-adapted cis-isomer of fluorosurfactants displayed good thermal stability at ambient temperature, with little reversion to the stable trans isomer after 16 h. These novel, light-responsive materials should find broad interest in a range of biomedical and technological fields, including drug and gene delivery, self-cleaning oleophobic surfaces, and antibacterial coatings for medical devices.

Lithiation and Stereoselective Transformations of 3-Aroyl-2,2,4,4-tetramethyloxazolidines (TMO Amides), a New Class of Acid-labile Atropisomeric Amides

Synlett ◽  
2002 ◽  
Vol 2002 (02) ◽  
pp. 0290-0294 ◽  
Author(s):  
Mark Anstiss ◽  
Jonathan Clayden ◽  
Alexander Grube ◽  
Latifa H. Youssef
Keyword(s):  
New Class ◽  
Acid Labile

Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

2012 ◽  
Vol 3 (9) ◽  
pp. 2502 ◽  
Author(s):  
Sophie Monge ◽  
Sarah Antoniacomi ◽  
Vincent Lapinte ◽  
Vincent Darcos ◽  
Jean-Jacques Robin
Keyword(s):  
Thermosensitive Polymers ◽  
New Class ◽  
Acid Labile

Towards Automated Design of Mechanically Functional Molecules

2015 ◽  
Author(s):  
Charles A. Manion ◽  
Ryan Arlitt ◽  
Irem Tumer ◽  
Matthew I. Campbell ◽  
P. Alex Greaney
Keyword(s):  
Smart Materials ◽  
De Novo ◽  
Molecular Design ◽  
Metal Organic Framework ◽  
Automated Design ◽  
Computational Approach ◽  
Responsive Materials ◽  
New Class ◽  
De Novo Molecular Design ◽  
Metal Organic

Metal Organic Responsive Frameworks (MORFs) are a proposed new class of smart materials consisting of a Metal Organic Framework (MOF) with photoisomerizing beams (also known as linkers) that fold in response to light. Within a device these new light responsive materials could provide the capabilities such as photo-actuation, photo-tunable rigidity, and photo-tunable porosity. However, conventional MOF architectures are too rigid to allow isomerization of photoactive sub-molecules. We propose a new computational approach for designing MOF linkers to have the required mechanical properties to allow the photoisomer to fold by borrowing concepts from de novo molecular design and graph synthesis. Here we show how this approach can be used to design compliant linkers with the necessary flexibility to be actuated by photoisomerization and used to design MORFs with desired functionality.

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