scholarly journals Novel opioid detoxification using loperamide and P‐glycoprotein inhibitor

2019 ◽  
Vol 23 (4) ◽  
pp. 19-24
Author(s):  
Mohamed Al Garhy ◽  
Jennifer Jean Williams ◽  
Sona Mohan ◽  
Hana Abu Sharib
Keyword(s):  
P Glycoprotein ◽  
Opioid Detoxification

scholarly journals Loperamide and P‐glycoprotein modulator in opioid detoxification

2021 ◽  
Vol 25 (3) ◽  
pp. 25-28
Author(s):  
Mohamed Al Garhy ◽  
Sona Mohan ◽  
Aisha Al Dhufairi
Keyword(s):  
P Glycoprotein ◽  
Opioid Detoxification

Pharmacogenetics of Clozapine: In Vivo Role of Cytochrome P450 Isoforms and P-Glycoprotein

2008 ◽  
Vol 41 (05) ◽  
Author(s):  
E Jaquenoud-Sirot ◽  
B Knezevic ◽  
G Perla Morena ◽  
P Baumann ◽  
CB Eap
Keyword(s):  
Cytochrome P450 ◽  
P Glycoprotein ◽  
Cytochrome P450 Isoforms

Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Reis ◽  
RJ Ferreira ◽  
MMM Santos ◽  
DJVA dos Santos ◽  
J Molnár ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
P Glycoprotein

The neuroendocrinological role of P-glycoprotein

2005 ◽  
Vol 113 (08) ◽  
Author(s):  
M Ebinger ◽  
MB Müller ◽  
M Uhr
Keyword(s):  
P Glycoprotein

The Stress Respond, Related To the Opioid Abstinence And Detoxification: literature review

2014 ◽  
Vol 21 (1) ◽  
pp. 86-90
Author(s):  
Robertas Badaras ◽  
Gabija Dragelytė ◽  
Indrė Vaitekonytė ◽  
Juozas Ivaškevičius ◽  
Jūratė Šipylaitė
Keyword(s):  
Opioid Dependence ◽  
Financial Resources ◽  
Successful Completion ◽  
Minimum Risk ◽  
Medical Databases ◽  
Dosing Regimens ◽  
Naltrexone Treatment ◽  
Dopaminergic Pathways ◽  
Pituitary Adrenal Axis ◽  
Opioid Detoxification

Materials and Methods. Published articles on the opioid abuse and methods of opioid detoxification were identified by searching medical databases, using corresponding literature and were also searched manually for applicable papers. The search was limited to articles published from 1985 through 2014. Results. Opioid dependence determine pathophysiologic changes in the dopaminergic pathways of the organism, as well as the alterations in the stress-responsive hypothalamic-pituitary-adrenal axis. The usage of opioid antagonists in the early stages of withdrawal, can lead the effectiveness of opioid detoxification to 100%. Rapid opioid detoxification do not remove all the symptoms of abstinence. Negative aspects, concerning the procedure, while using prevention, can be reduced to the minimum risk. Rapid opioid detoxification, comparing it with Ultrarapid opioid detoxification procedure, diverges as less financial resources and a lower risk containing technique. Conclusions. Use of antagonists may reduce the duration of withdrawal, thus reducing the overall severity of withdrawal and increasing the chances of successful completion. This technique facilitates commencement of naltrexone treatment. Dosing regimens used in clinical trials vary. Subsequent results do not correlate with the methods of detoxification.

Outpatient Non-Opioid Detoxification for Opioid Withdrawal:Who Is Likely to Benefit?

1997 ◽  
Vol 6 (3) ◽  
pp. 218-223 ◽  
Author(s):  
Michael J. McCann ◽  
Karen Miotto ◽  
Richard A. Rawson ◽  
Alice Huber ◽  
Steven Shoptaw ◽  
...  
Keyword(s):  
Opioid Detoxification
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